HAMAP rule MF_02123
General rule information
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| Accession | MF_02123 |
| Dates | 29-AUG-2011 (Created)
2-SEP-2024 (Last updated, Version 15) |
| Name | F420_G6P_DH |
| Scope(s) |
Bacteria Actinomycetota |
| Template(s) | A0QQJ4 (FGD_MYCS2); P9WNE1 (FGD_MYCTU); [ Recover all ] |
| Triggered by |
HAMAP; MF_02123 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FGD |
| Protein name | RecName: Full=F420-dependent glucose-6-phosphate dehydrogenase; Short=FGD; Short=G6PD; EC=1.1.98.2; |
| Gene name | Name=fgd; |
Comments
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| case <OC:Mycobacterium> | |
| FUNCTION | Catalyzes the coenzyme F420-dependent oxidation of glucose 6- phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria. |
| else | |
| FUNCTION | Catalyzes the coenzyme F420-dependent oxidation of glucose 6- phosphate (G6P) to 6-phosphogluconolactone. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=oxidized coenzyme F420-(gamma-L-Glu)(n) + D-glucose 6- phosphate + H(+) = 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-L-Glu)(n); Xref=Rhea:RHEA:27294, Rhea:RHEA-COMP:12939, Rhea:RHEA-COMP:14378, ChEBI:CHEBI:15378, ChEBI:CHEBI:57955, ChEBI:CHEBI:61548, ChEBI:CHEBI:133980, ChEBI:CHEBI:139511; EC=1.1.98.2; |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family. |
Keywords
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Gene Ontology
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| GO:0016614; Molecular function:oxidoreductase activity, acting on CH-OH group of donors |
| GO:0070967; Molecular function:coenzyme F420 binding |
| GO:0005975; Biological process:carbohydrate metabolic process |
Cross-references
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| Pfam | PF00296; Bac_luciferase; 1; |
| NCBIfam | TIGR03554; F420_G6P_DH; 1; |
| NCBIfam | TIGR03557; F420_G6P_family; 1; |
Features
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| From: FGD_MYCTU (P9WNE1) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 107 | 108 | /ligand="coenzyme F420-(gamma-Glu)n" /ligand_id="ChEBI:CHEBI:133980" |
[TS]-G | ||||||||
| BINDING | 177 | 178 | /ligand="coenzyme F420-(gamma-Glu)n" /ligand_id="ChEBI:CHEBI:133980" |
[GS]-G | ||||||||
| BINDING | 180 | 181 | /ligand="coenzyme F420-(gamma-Glu)n" /ligand_id="ChEBI:CHEBI:133980" |
[VALGSEQ]-[VMA] | ||||||||
| ACT_SITE | 40 | 40 | /note="Proton donor" | H | ||||||||
| ACT_SITE | 109 | 109 | /note="Proton acceptor" | E | ||||||||
| BINDING | 39 | 39 | /ligand="coenzyme F420-(gamma-Glu)n" /ligand_id="ChEBI:CHEBI:133980" |
D | ||||||||
| BINDING | 76 | 76 | /ligand="coenzyme F420-(gamma-Glu)n" /ligand_id="ChEBI:CHEBI:133980" |
T | ||||||||
| BINDING | 112 | 112 | /ligand="coenzyme F420-(gamma-Glu)n" /ligand_id="ChEBI:CHEBI:133980" |
N | ||||||||
| BINDING | 195 | 195 | /ligand="substrate" | T | ||||||||
| BINDING | 198 | 198 | /ligand="substrate" | K | ||||||||
| BINDING | 259 | 259 | /ligand="substrate" | K | ||||||||
| BINDING | 283 | 283 | /ligand="substrate" | R | ||||||||
Additional information
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| Size range | 330-345 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |