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Annotation rule MF_02123
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General rule information [?]

Accession MF_02123
Dates 29-AUG-2011 (Created)
13-JAN-2021 (Last updated, Version 8)
Name F420_G6P_DH
Scope
Bacteria; Actinobacteria
Templates A0QQJ4 (FGD_MYCS2); P9WNE1 (FGD_MYCTU): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
FGD
Protein name
RecName: Full=F420-dependent glucose-6-phosphate dehydrogenase;
Short=FGD;
Short=G6PD;
EC 1.1.98.2;
Gene name
fgd

Comments [?]

case <OC:Mycobacterium>
Function Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria.
else
Function Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone.
end case
Catalytic activity RHEA:27294: D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) = 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-Glu)(n)
EC 1.1.98.2
Subunit Homodimer.
Similarity Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family.

Keywords [?]

Carbohydrate metabolism
Oxidoreductase

Gene Ontology [?]

GO:0016614; Molecular function: oxidoreductase activity, acting on CH-OH group of donors.
GO:0070967; Molecular function: coenzyme F420 binding.
GO:0005975; Biological process: carbohydrate metabolic process.

Cross-references [?]

Pfam PF00296; Bac_luciferase; 1;
TIGRFAMs TIGR03554; F420_G6P_DH; 1;
TIGR03557; F420_G6P_family; 1;

Features [?]

From: FGD_MYCTU (P9WNE1)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     107     108       F420 binding     [TS]-G  
REGION     177     178       F420 binding     [GS]-G  
REGION     180     181       F420 binding     [VALGSEQ]-[VMA]  
ACT_SITE     40     40       Proton donor     H  
ACT_SITE     109     109       Proton acceptor     E  
BINDING     39     39       F420     D  
BINDING     76     76       F420     T  
BINDING     112     112       F420     N  
BINDING     195     195       Substrate     T  
BINDING     198     198       Substrate     K  
BINDING     259     259       Substrate     K  
BINDING     283     283       Substrate     R  

Additional information [?]

Size range 330-345 amino acids
Related rules None
Fusion None


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