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Annotation rule MF_02123 |
Accession | MF_02123 |
Dates | 29-AUG-2011 (Created) 20-NOV-2019 (Last updated, Version 7) |
Name | F420_G6P_DH |
Scope | Bacteria; Actinobacteria |
Templates | A0QQJ4 (FGD_MYCS2); P9WNE1 (FGD_MYCTU): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria. |
Function | Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone. |
Catalytic activity | RHEA:27294: D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) = 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-Glu)(n)
EC 1.1.98.2 |
Subunit | Homodimer. |
Similarity | Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family. |
From: FGD_MYCTU (P9WNE1) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 107 | 108 | F420 binding | [TS]-G | ||||||||
REGION | 177 | 178 | F420 binding | [GS]-G | ||||||||
REGION | 180 | 181 | F420 binding | [VALGSEQ]-[VMA] | ||||||||
ACT_SITE | 40 | 40 | Proton donor | H | ||||||||
ACT_SITE | 109 | 109 | Proton acceptor | E | ||||||||
BINDING | 39 | 39 | F420 | D | ||||||||
BINDING | 76 | 76 | F420 | T | ||||||||
BINDING | 112 | 112 | F420 | N | ||||||||
BINDING | 195 | 195 | Substrate | T | ||||||||
BINDING | 198 | 198 | Substrate | K | ||||||||
BINDING | 259 | 259 | Substrate | K | ||||||||
BINDING | 283 | 283 | Substrate | R |
Size range | 330-345 amino acids |
Related rules | None |
Fusion | None |