HAMAP rule MF_02126

General rule information [?]

Accession	MF_02126
Dates	28-OCT-2011 (Created) 19-NOV-2022 (Last updated, Version 9)

Name	RF_methyltr_PrmC

Scope

Bacteria

Templates

P0ACC1 (PRMC_ECOLI); Q9WYV8 (PRMC_THEMA); B0B9D1 (PRMC_CHLT2): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

PRMC

Protein name

RecName:		Full=Release factor glutamine methyltransferase;
		Short=RF MTase;
		EC 2.1.1.297;
AltName:		Full=N5-glutamine methyltransferase PrmC;
AltName:		Full=Protein-(glutamine-N5) MTase PrmC;
AltName:		Full=Protein-glutamine N-methyltransferase PrmC;

Gene name

prmC

Comments [?]

Function	Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
Catalytic activity	RHEA:42896: L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine EC 2.1.1.297
Similarity	Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.

Keywords [?]

Gene Ontology [?]

GO:0036009; Molecular function: protein-glutamine N-methyltransferase activity.
GO:0018364; Biological process: peptidyl-glutamine methylation.

Cross-references [?]

Features [?]

From: PRMC_ECOLI (P0ACC1)

Key From To Description Tag Condition FTGroup

BINDING (Optional) 117 121 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 G-x-G-x-G

BINDING 183 186 /ligand="substrate N-P-P-Y

BINDING 140 140 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 [DE]

BINDING (Optional) 168 168 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 [WF]

BINDING 183 183 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 N

Additional information [?]