HAMAP rule MF_02126
General rule information
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Accession | MF_02126 |
Dates | 28-OCT-2011 (Created) 19-NOV-2022 (Last updated, Version 9) |
Name | RF_methyltr_PrmC |
Scope | Bacteria |
Templates | P0ACC1 (PRMC_ECOLI); Q9WYV8 (PRMC_THEMA); B0B9D1 (PRMC_CHLT2): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. |
Catalytic activity | RHEA:42896: L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine
EC 2.1.1.297 |
Similarity | Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. |
Keywords
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Gene Ontology
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GO:0036009; Molecular function: protein-glutamine N-methyltransferase activity.
GO:0018364; Biological process: peptidyl-glutamine methylation.
GO:0018364; Biological process: peptidyl-glutamine methylation.
Cross-references
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Features
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From: PRMC_ECOLI (P0ACC1) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 117 | 121 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | G-x-G-x-G | ||||||||
BINDING | 183 | 186 | /ligand="substrate | N-P-P-Y | ||||||||
BINDING | 140 | 140 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [DE] | ||||||||
BINDING (Optional) | 168 | 168 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [WF] | ||||||||
BINDING | 183 | 183 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | N |
Additional information
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Size range | 270-354 amino acids |
Related rules | None |
Fusion | Nter: None; Cter: MF_01057 (trmB) |