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HAMAP rule MF_02126

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General rule information [?]

Accession MF_02126
Dates 28-OCT-2011 (Created)
1-JUN-2023 (Last updated, Version 10)
Name RF_methyltr_PrmC
Scope(s) Bacteria
Template(s) P0ACC1 (PRMC_ECOLI); Q9WYV8 (PRMC_THEMA); B0B9D1 (PRMC_CHLT2); [ Recover all ]
Triggered by HAMAP; MF_02126 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PRMC
Protein name RecName: Full=Release factor glutamine methyltransferase;
                 Short=RF MTase;
AltName: Full=N5-glutamine methyltransferase PrmC;
AltName: Full=Protein-(glutamine-N5) MTase PrmC;
AltName: Full=Protein-glutamine N-methyltransferase PrmC;
Gene name Name=prmC;

Comments [?]

FUNCTIONMethylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
CATALYTIC ACTIVITY Reaction=L-glutaminyl-[peptide chain release factor] + S-adenosyl-L- methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42896, Rhea:RHEA- COMP:10271, Rhea:RHEA-COMP:10272, ChEBI:CHEBI:15378, ChEBI:CHEBI:30011, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61891; EC=;
SIMILARITYBelongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.

Keywords [?]

Gene Ontology [?]

GO:0036009; Molecular function:protein-glutamine N-methyltransferase activity
GO:0018364; Biological process:peptidyl-glutamine methylation

Cross-references [?]

Pfam PF05175; MTS; 1;
NCBIfam TIGR00536; HemK_fam; 1;
NCBIfam TIGR03534; RF_mod_PrmC; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 117 121 /ligand="S-adenosyl-L-methionine"
BINDING 183 186 /ligand="substrate" N-P-P-Y
BINDING 140 140 /ligand="S-adenosyl-L-methionine"
BINDING 168 168 /ligand="S-adenosyl-L-methionine"
BINDING 183 183 /ligand="S-adenosyl-L-methionine"

Additional information [?]

Size range 270-354 amino acids
Related rules None
Fusion Nter: None Cter: MF_01057 (trmB)

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