HAMAP rule MF_02126
General rule information
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| Accession | MF_02126 |
| Dates | 28-OCT-2011 (Created)
1-JUN-2023 (Last updated, Version 10) |
| Name | RF_methyltr_PrmC |
| Scope(s) |
Bacteria |
| Template(s) | P0ACC1 (PRMC_ECOLI); Q9WYV8 (PRMC_THEMA); B0B9D1 (PRMC_CHLT2); [ Recover all ] |
| Triggered by |
HAMAP; MF_02126 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PRMC |
| Protein name | RecName: Full=Release factor glutamine methyltransferase; Short=RF MTase; EC=2.1.1.297; AltName: Full=N5-glutamine methyltransferase PrmC; AltName: Full=Protein-(glutamine-N5) MTase PrmC; AltName: Full=Protein-glutamine N-methyltransferase PrmC; |
| Gene name | Name=prmC; |
Comments
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| FUNCTION | Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. |
| CATALYTIC ACTIVITY | Reaction=L-glutaminyl-[peptide chain release factor] + S-adenosyl-L- methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42896, Rhea:RHEA- COMP:10271, Rhea:RHEA-COMP:10272, ChEBI:CHEBI:15378, ChEBI:CHEBI:30011, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61891; EC=2.1.1.297; |
| SIMILARITY | Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. |
Keywords
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Gene Ontology
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| GO:0036009; Molecular function:protein-glutamine N-methyltransferase activity |
| GO:0018364; Biological process:peptidyl-glutamine methylation |
Cross-references
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Features
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| From: PRMC_ECOLI (P0ACC1) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 117 | 121 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
G-x-G-x-G | ||||||||
| BINDING | 183 | 186 | /ligand="substrate" | N-P-P-Y | ||||||||
| BINDING | 140 | 140 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[DE] | ||||||||
| BINDING | 168 | 168 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[WF] | ||||||||
| BINDING | 183 | 183 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
N | ||||||||
Additional information
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| Size range | 270-354 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: MF_01057 (trmB) |