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Annotation rule MF_02126
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General rule information [?]

Accession MF_02126
Dates 28-OCT-2011 (Created)
20-NOV-2019 (Last updated, Version 6)
Name RF_methyltr_PrmC
Scope
Bacteria
Templates P0ACC1 (PRMC_ECOLI); Q9WYV8 (PRMC_THEMA); B0B9D1 (PRMC_CHLT2): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PRMC
Protein name
RecName: Full=Release factor glutamine methyltransferase;
Short=RF MTase;
EC 2.1.1.297;
AltName: Full=N5-glutamine methyltransferase PrmC;
AltName: Full=Protein-(glutamine-N5) MTase PrmC;
AltName: Full=Protein-glutamine N-methyltransferase PrmC;
Gene name
prmC

Comments [?]

Function Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
Catalytic activity RHEA:42896: L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine
EC 2.1.1.297
Similarity Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.

Keywords [?]

Methyltransferase
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0036009; Molecular function: protein-glutamine N-methyltransferase activity.
GO:0018364; Biological process: peptidyl-glutamine methylation.

Cross-references [?]

Pfam PF05175; MTS; 1;
TIGRFAMs TIGR00536; HemK_fam; 1;
TIGR03534; RF_mod_PrmC; 1;

Features [?]

From: PRMC_ECOLI (P0ACC1)
Key     From     To       Description   Tag   Condition   FTGroup
REGION (Optional)     117     121       S-adenosyl-L-methionine binding     G-x-G-x-G  
REGION     183     186       Substrate binding     N-P-P-Y  
BINDING     140     140       S-adenosyl-L-methionine     [DE]  
BINDING (Optional)     168     168       S-adenosyl-L-methionine     [WF]  
BINDING     183     183       S-adenosyl-L-methionine     N  

Additional information [?]

Size range 270-354 amino acids
Related rules None
Fusion Nter: None; Cter: MF_01057 (trmB)


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