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Annotation rule MF_02128 |
Accession | MF_02128 |
Dates | 3-JAN-2012 (Created) 20-NOV-2019 (Last updated, Version 7) |
Name | TMP_kinase |
Scope | Bacteria
Archaea |
Templates | O67883 (THIL_AQUAE); P55881 (THIL_SALTY); P0AGG0 (THIL_ECOLI); A3MTW6 (THIL_PYRCJ): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1. |
Catalytic activity | RHEA:15913: ATP + thiamine phosphate = ADP + thiamine diphosphate
EC 2.7.4.16 |
Pathway | Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1. |
Miscellaneous | Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. |
Similarity | Belongs to the thiamine-monophosphate kinase family. |
Pfam | PF00586; AIRS; 1; |
PF02769; AIRS_C; 1; | |
TIGRFAMs | TIGR01379; ThiL; 1; |
PIRSF | PIRSF005303; Thiam_monoph_kin; 1; |
From: THIL_AQUAE (O67883) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND | 118 | 119 | ATP | G-[ND] | ||||||||
METAL | 27 | 27 | Magnesium 3 | [DE] | ||||||||
METAL | 27 | 27 | Magnesium 4; via carbonyl oxygen | [DE] | ||||||||
METAL | 41 | 41 | Magnesium 4 | [TS] | ||||||||
METAL | 42 | 42 | Magnesium 1; via carbonyl oxygen | [TS] | ||||||||
METAL | 43 | 43 | Magnesium 1 | D | ||||||||
METAL | 43 | 43 | Magnesium 2 | D | ||||||||
METAL | 71 | 71 | Magnesium 2 | D | ||||||||
METAL | 71 | 71 | Magnesium 3 | D | ||||||||
METAL | 71 | 71 | Magnesium 4 | D | ||||||||
METAL | 119 | 119 | Magnesium 1 | [ND] | ||||||||
METAL | 207 | 207 | Magnesium 3 | D | ||||||||
METAL | 210 | 210 | Magnesium 5 | D | ||||||||
BINDING | 50 | 50 | Substrate | [HD] | ||||||||
BINDING (Optional) | 101 | 101 | ATP | Y | ||||||||
BINDING (Optional) | 142 | 142 | ATP | [RK] | ||||||||
BINDING | 209 | 209 | ATP | [ST] | ||||||||
BINDING | 260 | 260 | Substrate | [ED] | ||||||||
BINDING | 303 | 303 | Substrate | [WYF] |
Size range | 286-352 amino acids |
Related rules | None |
Fusion | None |