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Annotation rule MF_02130
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General rule information [?]

Accession MF_02130
Dates 12-OCT-2012 (Created)
20-NOV-2019 (Last updated, Version 6)
Name DHNA_arch
Scope
Archaea
Templates Q57851 (MPTD_METJA); Q8TX89 (MPTD_METKA); Q6L2J9 (MPTD_PICTO): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MPTD
Protein name
RecName: Full=Dihydroneopterin aldolase;
Short=DHNA;
EC 4.1.2.25;
AltName: Full=7,8-dihydroneopterin aldolase;
Gene name
mptD

Comments [?]

Function Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
Catalytic activity RHEA:10540: 7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde
EC 4.1.2.25
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi>
Pathway Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis.
end case
case <OC:Halobacteria> or <OC:Methanosarcina>
Pathway Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.
end case
Subunit Homotetramer.
Similarity Belongs to the archaeal dihydroneopterin aldolase family.

Keywords [?]

case <OC:Halobacteria> or <OC:Methanosarcina>
end case

Gene Ontology [?]

GO:0004150; Molecular function: dihydroneopterin aldolase activity.
case <OC:Halobacteria> or <OC:Methanosarcina>
GO:0046654; Biological process: tetrahydrofolate biosynthetic process.
end case
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi>
GO:2001118; Biological process: tetrahydromethanopterin biosynthetic process.
end case

Cross-references [?]

Pfam PF04036; DUF372; 1;
PF04038; DUF381; 1;

Features [?]

From: MPTD_METJA (Q57851)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     25     25       Substrate     E  
BINDING     114     114       Substrate; via amide nitrogen and carbonyl oxygen     M  

Additional information [?]

Size range 107-158 amino acids
Related rules None
Fusion None