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HAMAP rule MF_02130

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General rule information [?]

Accession MF_02130
Dates 12-OCT-2012 (Created)
14-MAY-2022 (Last updated, Version 7)
Name DHNA_arch
Scope(s) Archaea
Template(s) Q57851 (MPTD_METJA); Q8TX89 (MPTD_METKA); Q6L2J9 (MPTD_PICTO); [ Recover all ]
Triggered by HAMAP; MF_02130 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MPTD
Protein name RecName: Full=Dihydroneopterin aldolase;
AltName: Full=7,8-dihydroneopterin aldolase;
Gene name Name=mptD;

Comments [?]

FUNCTIONCatalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
CATALYTIC ACTIVITY Reaction=7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde; Xref=Rhea:RHEA:10540, ChEBI:CHEBI:17001, ChEBI:CHEBI:17071, ChEBI:CHEBI:44841; EC=;
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi>
PATHWAYCofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis.
end case
case <OC:Halobacteria> or <OC:Methanosarcina>
PATHWAYCofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino- 4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8- dihydroneopterin triphosphate: step 3/4.
end case
SIMILARITYBelongs to the archaeal dihydroneopterin aldolase family.

Keywords [?]

case <OC:Halobacteria> or <OC:Methanosarcina>
Folate biosynthesis
end case

Gene Ontology [?]

GO:0004150; Molecular function:dihydroneopterin aldolase activity
case <OCellular component:Halobacteria> or <OC:Methanosarcina>
GO:0046654; Biological process:tetrahydrofolate biosynthetic process
end case
case <OCellular component:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi>
GO:2001118; Biological process:tetrahydromethanopterin biosynthetic process
end case

Cross-references [?]

Pfam PF04036; DUF372; 1;
Pfam PF04038; DUF381; 1;

Features [?]

From: MPTD_METJA (Q57851)
Key From To Description Tag Condition FTGroup
BINDING 25 25 /ligand="substrate" E
BINDING 114 114 /ligand="substrate" M

Additional information [?]

Size range 107-158 amino acids
Related rules None
Fusion Nter: None Cter: None

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