HAMAP rule MF_02130
General rule information
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Accession | MF_02130 |
Dates | 12-OCT-2012 (Created)
14-MAY-2022 (Last updated, Version 7) |
Name | DHNA_arch |
Scope(s) |
Archaea |
Template(s) | Q57851 (MPTD_METJA); Q8TX89 (MPTD_METKA); Q6L2J9 (MPTD_PICTO); [ Recover all ] |
Triggered by |
HAMAP; MF_02130 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MPTD |
Protein name | RecName: Full=Dihydroneopterin aldolase; Short=DHNA; EC=4.1.2.25; AltName: Full=7,8-dihydroneopterin aldolase; |
Gene name | Name=mptD; |
Comments
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FUNCTION | Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD). |
CATALYTIC ACTIVITY | Reaction=7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde; Xref=Rhea:RHEA:10540, ChEBI:CHEBI:17001, ChEBI:CHEBI:17071, ChEBI:CHEBI:44841; EC=4.1.2.25; |
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi> | |
PATHWAY | Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis. |
end case | |
case <OC:Halobacteria> or <OC:Methanosarcina> | |
PATHWAY | Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino- 4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8- dihydroneopterin triphosphate: step 3/4. |
end case | |
SUBUNIT | Homotetramer. |
SIMILARITY | Belongs to the archaeal dihydroneopterin aldolase family. |
Keywords
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case <OC:Halobacteria> or <OC:Methanosarcina> | |
Folate biosynthesis | |
end case | |
Lyase |
Gene Ontology
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GO:0004150; Molecular function:dihydroneopterin aldolase activity | |
case <OCellular component:Halobacteria> or <OC:Methanosarcina> | |
GO:0046654; Biological process:tetrahydrofolate biosynthetic process | |
end case | |
case <OCellular component:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi> | |
GO:2001118; Biological process:tetrahydromethanopterin biosynthetic process | |
end case |
Cross-references
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Features
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From: MPTD_METJA (Q57851) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 25 | 25 | /ligand="substrate" | E | ||||||||
BINDING | 114 | 114 | /ligand="substrate" | M |
Additional information
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Size range | 107-158 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |