HAMAP rule MF_02130
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_02130 |
| Accession | MF_02130 |
| Dates | 12-OCT-2012 (Created)
14-MAY-2022 (Last updated, Version 8) |
| Name | DHNA_arch |
| Scope(s) |
Archaea |
| Template(s) | Q57851; Q8TX89; Q6L2J9; [ Recover all ] |
| Triggered by |
HAMAP; MF_02130 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MPTD |
| Protein name | RecName: Full=Dihydroneopterin aldolase; Short=DHNA; EC=4.1.2.25; AltName: Full=7,8-dihydroneopterin aldolase; |
| Gene name | Name=mptD; |
Comments
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| FUNCTION | Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD). |
| CATALYTIC ACTIVITY | Reaction=7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde; Xref=Rhea:RHEA:10540, ChEBI:CHEBI:17001, ChEBI:CHEBI:17071, ChEBI:CHEBI:44841; EC=4.1.2.25; |
| case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi> | |
| PATHWAY | Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis. |
| end case | |
| case <OC:Halobacteria> or <OC:Methanosarcina> | |
| PATHWAY | Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino- 4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8- dihydroneopterin triphosphate: step 3/4. |
| end case | |
| SUBUNIT | Homotetramer. |
| SIMILARITY | Belongs to the archaeal dihydroneopterin aldolase family. |
Keywords
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| case <OC:Halobacteria> or <OC:Methanosarcina> | |
| Folate biosynthesis | |
| end case | |
| Lyase | |
Gene Ontology
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| GO:0004150; Molecular function:dihydroneopterin aldolase activity | |
| case <OCellular component:Halobacteria> or <OC:Methanosarcina> | |
| GO:0046654; Biological process:tetrahydrofolate biosynthetic process | |
| end case | |
| case <OCellular component:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi> | |
| GO:2001118; Biological process:tetrahydromethanopterin biosynthetic process | |
| end case | |
Cross-references
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Features
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| From: MPTD_METJA (Q57851) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 25 | 25 | /ligand="substrate" | E | ||||||||
| BINDING | 114 | 114 | /ligand="substrate" | M | ||||||||
Additional information
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| Size range | 107-158 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |