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Annotation rule MF_02130 |
General rule information
[?]
Accession |
MF_02130 |
Dates |
12-OCT-2012 (Created) 20-NOV-2019 (Last updated, Version 6) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Dihydroneopterin aldolase;
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Short=DHNA;
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EC 4.1.2.25;
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AltName:
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Full=7,8-dihydroneopterin aldolase;
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Function |
Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD). |
Catalytic activity |
RHEA:10540: 7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde
EC 4.1.2.25
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case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi>
Pathway |
Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis. |
end case
case <OC:Halobacteria> or <OC:Methanosarcina>
Pathway |
Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4. |
end case
Subunit |
Homotetramer. |
Similarity |
Belongs to the archaeal dihydroneopterin aldolase family. |
case <OC:Halobacteria> or <OC:Methanosarcina>
end case
GO:0004150; Molecular function: dihydroneopterin aldolase activity.
case <OC:Halobacteria> or <OC:Methanosarcina>
GO:0046654; Biological process: tetrahydrofolate biosynthetic process.
end case
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi>
GO:2001118; Biological process: tetrahydromethanopterin biosynthetic process.
end case
From: MPTD_METJA (Q57851) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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BINDING
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25
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25
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Substrate
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E
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BINDING
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114
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114
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Substrate; via amide nitrogen and carbonyl oxygen
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M
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Additional information
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Size range |
107-158 amino acids |
Related rules |
None |
Fusion |
None |