HAMAP rule MF_02131
General rule information
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Accession | MF_02131 |
Dates | 12-OCT-2012 (Created) 20-NOV-2019 (Last updated, Version 6) |
Name | HMPDK_arch |
Scope | Archaea |
Templates | Q59028 (MPTE_METJA); Q8U2A9 (MPTE_PYRFU): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP). |
Catalytic activity | RHEA:11412: 6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)
EC 2.7.6.3 |
Cofactor | Mg(2+) |
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi>
Pathway | Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis. |
end case
case <OC:Halobacteria> or <OC:Methanosarcina>
Pathway | Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4. |
end case
Similarity | Belongs to the archaeal 6-HMPDK family. |
Keywords
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case <OC:Halobacteria> or <OC:Methanosarcina>
end case
Gene Ontology
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GO:0000287; Molecular function: magnesium ion binding.
GO:0003848; Molecular function: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity.
GO:0005524; Molecular function: ATP binding.
GO:0003848; Molecular function: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity.
GO:0005524; Molecular function: ATP binding.
case <OC:Halobacteria> or <OC:Methanosarcina>
GO:0046654; Biological process: tetrahydrofolate biosynthetic process.
end case
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi>
GO:2001118; Biological process: tetrahydromethanopterin biosynthetic process.
end case
Cross-references
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Pfam | PF01973; MAF_flag10; 1; |
Additional information
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Size range | 183-273 amino acids |
Related rules | None |
Fusion | None |