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HAMAP rule MF_02131

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General rule information [?]

Accession MF_02131
Dates 12-OCT-2012 (Created)
20-NOV-2019 (Last updated, Version 6)
Name HMPDK_arch
Scope
Archaea
Templates Q59028 (MPTE_METJA); Q8U2A9 (MPTE_PYRFU): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MPTE
Protein name
RecName: Full=6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase;
Short=HPPK;
EC 2.7.6.3;
AltName: Full=2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase;
AltName: Full=6-hydroxymethyl-7,8-dihydropterin diphosphokinase;
Short=6-HMPDK;
AltName: Full=7,8-dihydro-6-hydroxymethylpterin diphosphokinase;
AltName: Full=7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase;
Short=PPPK;
Gene name
mptE

Comments [?]

Function Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).
Catalytic activity RHEA:11412: 6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)
EC 2.7.6.3
Cofactor Mg(2+)
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi>
Pathway Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis.
end case
case <OC:Halobacteria> or <OC:Methanosarcina>
Pathway Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.
end case
Similarity Belongs to the archaeal 6-HMPDK family.

Keywords [?]

ATP-binding
Kinase
Magnesium
Nucleotide-binding
Transferase
case <OC:Halobacteria> or <OC:Methanosarcina>
Folate biosynthesis
end case

Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0003848; Molecular function: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity.
GO:0005524; Molecular function: ATP binding.
case <OC:Halobacteria> or <OC:Methanosarcina>
GO:0046654; Biological process: tetrahydrofolate biosynthetic process.
end case
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi>
GO:2001118; Biological process: tetrahydromethanopterin biosynthetic process.
end case

Cross-references [?]

Pfam PF01973; MAF_flag10; 1;

Additional information [?]

Size range 183-273 amino acids
Related rules None
Fusion None


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