HAMAP rule MF_02131
General rule information
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| Accession | MF_02131 |
| Dates | 12-OCT-2012 (Created)
20-NOV-2019 (Last updated, Version 6) |
| Name | HMPDK_arch |
| Scope(s) |
Archaea |
| Template(s) | Q59028 (MPTE_METJA); Q8U2A9 (MPTE_PYRFU); [ Recover all ] |
| Triggered by |
HAMAP; MF_02131 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MPTE |
| Protein name | RecName: Full=6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; Short=HPPK; EC=2.7.6.3; AltName: Full=2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; AltName: Full=6-hydroxymethyl-7,8-dihydropterin diphosphokinase; Short=6-HMPDK; AltName: Full=7,8-dihydro-6-hydroxymethylpterin diphosphokinase; AltName: Full=7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase; Short=PPPK; |
| Gene name | Name=mptE; |
Comments
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| FUNCTION | Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP). |
| CATALYTIC ACTIVITY | Reaction=6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin- 6-yl)methyl diphosphate + AMP + H(+); Xref=Rhea:RHEA:11412, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:44841, ChEBI:CHEBI:72950, ChEBI:CHEBI:456215; EC=2.7.6.3; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi> | |
| PATHWAY | Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis. |
| end case | |
| case <OC:Halobacteria> or <OC:Methanosarcina> | |
| PATHWAY | Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino- 4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8- dihydroneopterin triphosphate: step 4/4. |
| end case | |
| SIMILARITY | Belongs to the archaeal 6-HMPDK family. |
Keywords
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| ATP-binding | |
| Kinase | |
| Magnesium | |
| Nucleotide-binding | |
| Transferase | |
| case <OC:Halobacteria> or <OC:Methanosarcina> | |
| Folate biosynthesis | |
| end case | |
Gene Ontology
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| GO:0000287; Molecular function:magnesium ion binding | |
| GO:0003848; Molecular function:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity | |
| GO:0005524; Molecular function:ATP binding | |
| case <OCellular component:Halobacteria> or <OC:Methanosarcina> | |
| GO:0046654; Biological process:tetrahydrofolate biosynthetic process | |
| end case | |
| case <OCellular component:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi> | |
| GO:2001118; Biological process:tetrahydromethanopterin biosynthetic process | |
| end case | |
Cross-references
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| Pfam | PF01973; MAF_flag10; 1; |
Features
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Additional information
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| Size range | 183-273 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |