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HAMAP rule MF_02131

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General rule information [?]

Accession MF_02131
Dates 12-OCT-2012 (Created)
20-NOV-2019 (Last updated, Version 6)
Name HMPDK_arch
Scope(s) Archaea
Template(s) Q59028 (MPTE_METJA); Q8U2A9 (MPTE_PYRFU); [ Recover all ]
Triggered by HAMAP; MF_02131 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MPTE
Protein name RecName: Full=6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase;
AltName: Full=2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase;
AltName: Full=6-hydroxymethyl-7,8-dihydropterin diphosphokinase;
AltName: Full=7,8-dihydro-6-hydroxymethylpterin diphosphokinase;
AltName: Full=7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase;
Gene name Name=mptE;

Comments [?]

FUNCTIONCatalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP).
CATALYTIC ACTIVITY Reaction=6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin- 6-yl)methyl diphosphate + AMP + H(+); Xref=Rhea:RHEA:11412, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:44841, ChEBI:CHEBI:72950, ChEBI:CHEBI:456215; EC=;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi>
PATHWAYCofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis.
end case
case <OC:Halobacteria> or <OC:Methanosarcina>
PATHWAYCofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino- 4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8- dihydroneopterin triphosphate: step 4/4.
end case
SIMILARITYBelongs to the archaeal 6-HMPDK family.

Keywords [?]

case <OC:Halobacteria> or <OC:Methanosarcina>
Folate biosynthesis
end case

Gene Ontology [?]

GO:0000287; Molecular function:magnesium ion binding
GO:0003848; Molecular function:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0005524; Molecular function:ATP binding
case <OCellular component:Halobacteria> or <OC:Methanosarcina>
GO:0046654; Biological process:tetrahydrofolate biosynthetic process
end case
case <OCellular component:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi>
GO:2001118; Biological process:tetrahydromethanopterin biosynthetic process
end case

Cross-references [?]

Pfam PF01973; MAF_flag10; 1;

Features [?]

Additional information [?]

Size range 183-273 amino acids
Related rules None
Fusion Nter: None Cter: None

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