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Annotation rule MF_02131 |
General rule information
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Accession |
MF_02131 |
Dates |
12-OCT-2012 (Created) 20-NOV-2019 (Last updated, Version 6) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase;
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Short=HPPK;
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EC 2.7.6.3;
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AltName:
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Full=2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase;
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AltName:
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Full=6-hydroxymethyl-7,8-dihydropterin diphosphokinase;
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Short=6-HMPDK;
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AltName:
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Full=7,8-dihydro-6-hydroxymethylpterin diphosphokinase;
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AltName:
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Full=7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase;
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Short=PPPK;
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Function |
Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP). |
Catalytic activity |
RHEA:11412: 6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)
EC 2.7.6.3
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Cofactor |
Mg(2+) |
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi>
Pathway |
Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis. |
end case
case <OC:Halobacteria> or <OC:Methanosarcina>
Pathway |
Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4. |
end case
Similarity |
Belongs to the archaeal 6-HMPDK family. |
case <OC:Halobacteria> or <OC:Methanosarcina>
end case
GO:0000287; Molecular function: magnesium ion binding.
GO:0003848; Molecular function: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity.
GO:0005524; Molecular function: ATP binding.
case <OC:Halobacteria> or <OC:Methanosarcina>
GO:0046654; Biological process: tetrahydrofolate biosynthetic process.
end case
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi>
GO:2001118; Biological process: tetrahydromethanopterin biosynthetic process.
end case
Additional information
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Size range |
183-273 amino acids |
Related rules |
None |
Fusion |
None |