HAMAP rule MF_02132
General rule information
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| Accession | MF_02132 |
| Dates | 16-MAY-2013 (Created)
2-SEP-2024 (Last updated, Version 14) |
| Name | AMP_phosphorylase |
| Scope(s) |
Archaea |
| Template(s) | Q5JCX3 (AMPPA_THEKO); [ Recover all ] |
| Triggered by |
case c? <OC:Archaea>
HAMAP; MF_02132 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | AMPPA |
| Protein name | RecName: Full=AMP phosphorylase; Short=AMPpase; EC=2.4.2.57; AltName: Full=Nucleoside monophosphate phosphorylase; Short=NMP phosphorylase; |
Comments
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| FUNCTION | Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. |
| CATALYTIC ACTIVITY | Reaction=AMP + phosphate = alpha-D-ribose 1,5-bisphosphate + adenine; Xref=Rhea:RHEA:36975, ChEBI:CHEBI:16708, ChEBI:CHEBI:43474, ChEBI:CHEBI:68688, ChEBI:CHEBI:456215; EC=2.4.2.57; |
| CATALYTIC ACTIVITY | Reaction=CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate; Xref=Rhea:RHEA:36987, ChEBI:CHEBI:16040, ChEBI:CHEBI:43474, ChEBI:CHEBI:60377, ChEBI:CHEBI:68688; EC=2.4.2.57; |
| CATALYTIC ACTIVITY | Reaction=UMP + phosphate = alpha-D-ribose 1,5-bisphosphate + uracil; Xref=Rhea:RHEA:36991, ChEBI:CHEBI:17568, ChEBI:CHEBI:43474, ChEBI:CHEBI:57865, ChEBI:CHEBI:68688; EC=2.4.2.57; |
| SIMILARITY | Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily. |
Keywords
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Gene Ontology
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| GO:0016208; Molecular function:AMP binding |
| GO:0016763; Molecular function:pentosyltransferase activity |
| GO:0006196; Biological process:AMP catabolic process |
Cross-references
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| Pfam | PF02885; Glycos_trans_3N; 1; |
| Pfam | PF00591; Glycos_transf_3; 1; |
| Pfam | PF07831; PYNP_C; 1; |
| NCBIfam | TIGR03327; AMP_phos; 1; |
| NCBIfam | TIGR02645; ARCH_P_rylase; 1; |
| PROSITE | PS00647; THYMID_PHOSPHORYLASE; 1; |
Features
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| From: AMPPA_THEKO (Q5JCX3) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 194 | 199 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
S-x-x-[IV]-T-[SG] | ||||||||
| ACT_SITE | 256 | 256 | /note="Proton donor" | D | ||||||||
| BINDING | 168 | 168 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
G | ||||||||
| BINDING | 203 | 203 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
T | ||||||||
| BINDING | 264 | 264 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
S | ||||||||
| BINDING | 288 | 288 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
K | ||||||||
Additional information
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| Size range | 500-516 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |