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HAMAP rule MF_02132

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General rule information [?]

Accession MF_02132
Dates 16-MAY-2013 (Created)
1-JUN-2023 (Last updated, Version 13)
Name AMP_phosphorylase
Scope(s) Archaea
Template(s) Q5JCX3 (AMPPA_THEKO); [ Recover all ]
Triggered by
case c? <OC:Archaea>
HAMAP; MF_02132 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier AMPPA
Protein name RecName: Full=AMP phosphorylase;
AltName: Full=Nucleoside monophosphate phosphorylase;
                 Short=NMP phosphorylase;

Comments [?]

FUNCTIONCatalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.
CATALYTIC ACTIVITY Reaction=AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate; Xref=Rhea:RHEA:36975, ChEBI:CHEBI:16708, ChEBI:CHEBI:43474, ChEBI:CHEBI:68688, ChEBI:CHEBI:456215; EC=;
CATALYTIC ACTIVITY Reaction=CMP + phosphate = alpha-D-ribose 1,5-bisphosphate + cytosine; Xref=Rhea:RHEA:36987, ChEBI:CHEBI:16040, ChEBI:CHEBI:43474, ChEBI:CHEBI:60377, ChEBI:CHEBI:68688; EC=;
CATALYTIC ACTIVITY Reaction=phosphate + UMP = alpha-D-ribose 1,5-bisphosphate + uracil; Xref=Rhea:RHEA:36991, ChEBI:CHEBI:17568, ChEBI:CHEBI:43474, ChEBI:CHEBI:57865, ChEBI:CHEBI:68688; EC=;
SIMILARITYBelongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016208; Molecular function:AMP binding
GO:0016763; Molecular function:pentosyltransferase activity
GO:0006196; Biological process:AMP catabolic process

Cross-references [?]

Pfam PF02885; Glycos_trans_3N; 1;
Pfam PF00591; Glycos_transf_3; 1;
Pfam PF07831; PYNP_C; 1;
NCBIfam TIGR03327; AMP_phos; 1;
NCBIfam TIGR02645; ARCH_P_rylase; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 194 199 /ligand="AMP"
ACT_SITE 256 256 /note="Proton donor" D
BINDING 168 168 /ligand="AMP"
BINDING 203 203 /ligand="AMP"
BINDING 264 264 /ligand="AMP"
BINDING 288 288 /ligand="AMP"

Additional information [?]

Size range 500-516 amino acids
Related rules None
Fusion Nter: None Cter: None

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