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Annotation rule MF_02132
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General rule information [?]

Accession MF_02132
Dates 16-MAY-2013 (Created)
20-NOV-2019 (Last updated, Version 9)
Name AMP_phosphorylase
Scope
Archaea
Template Q5JCX3 (AMPPA_THEKO)
case <OC:Archaea>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
AMPPA
Protein name
RecName: Full=AMP phosphorylase;
Short=AMPpase;
EC 2.4.2.57;
AltName: Full=Nucleoside monophosphate phosphorylase;
Short=NMP phosphorylase;

Comments [?]

Function Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.
Catalytic activity RHEA:36975: AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate
EC 2.4.2.57
RHEA:36987: CMP + phosphate = alpha-D-ribose 1,5-bisphosphate + cytosine
EC 2.4.2.57
RHEA:36991: phosphate + UMP = alpha-D-ribose 1,5-bisphosphate + uracil
EC 2.4.2.57
Similarity Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Keywords [?]

Glycosyltransferase
Transferase

Gene Ontology [?]

GO:0016208; Molecular function: AMP binding.
GO:0016763; Molecular function: transferase activity, transferring pentosyl groups.
GO:0006196; Biological process: AMP catabolic process.

Cross-references [?]

Pfam PF02885; Glycos_trans_3N; 1;
PF00591; Glycos_transf_3; 1;
PF07831; PYNP_C; 1;
TIGRFAMs TIGR03327; AMP_phos; 1;
TIGR02645; ARCH_P_rylase; 1;
PROSITE PS00647; THYMID_PHOSPHORYLASE; 1;

Features [?]

From: AMPPA_THEKO (Q5JCX3)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     194     199       AMP     S-x-x-[IV]-T-[SG]  
ACT_SITE     256     256       Proton donor     D  
BINDING     168     168       AMP; via amide nitrogen     G  
BINDING     203     203       AMP; via amide nitrogen     T  
BINDING     264     264       AMP     S  
BINDING     288     288       AMP     K  

Additional information [?]

Size range 500-516 amino acids
Related rules None
Fusion None


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