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HAMAP rule MF_02208

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General rule information [?]

Accession MF_02208
Dates 21-JAN-2019 (Created)
1-JUN-2023 (Last updated, Version 6)
Name MurD2_subfam
Scope(s) Bacteria
Template(s) Q2P5V2 (MURD2_XANOM); C4RJF7 (MURD2_MICS3); A4X981 (MURD2_SALTO); [ Recover all ]
Triggered by HAMAP; MF_02208 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MURD2
Protein name RecName: Full=UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase;
AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-L-glutamate synthetase;
                 Short=UDP-MurNAc-L-Ala-L-Glu synthetase;
Gene name Name=murD2;

Comments [?]

FUNCTIONCell wall formation. Catalyzes the addition of L-glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine.
CATALYTIC ACTIVITY Reaction=ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L- glutamate; Xref=Rhea:RHEA:58816, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:83898, ChEBI:CHEBI:142725, ChEBI:CHEBI:456216; EC=;
PATHWAYCell wall biogenesis; peptidoglycan biosynthesis.
SIMILARITYBelongs to the MurCDEF family. MurD2 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0016881; Molecular function:acid-amino acid ligase activity
GO:0009252; Biological process:peptidoglycan biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF08245; Mur_ligase_M; 1;
Pfam PF02875; Mur_ligase_C; 1;
NCBIfam TIGR01087; murD; 1;

Features [?]

From: MURD2_XANOM (Q2P5V2)
Key From To Description Tag Condition FTGroup
BINDING 122 128 /ligand="ATP"

Additional information [?]

Size range 400-500 amino acids
Related rules MF_00639
Fusion Nter: None Cter: None

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