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HAMAP rule MF_02208

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General rule information [?]

Accession MF_02208
Dates 21-JAN-2019 (Created)
1-JUN-2023 (Last updated, Version 6)
Name MurD2_subfam
Templates Q2P5V2 (MURD2_XANOM); C4RJF7 (MURD2_MICS3); A4X981 (MURD2_SALTO): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase;
AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-L-glutamate synthetase;
Short=UDP-MurNAc-L-Ala-L-Glu synthetase;
Gene name

Comments [?]

Function Cell wall formation. Catalyzes the addition of L-glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine.
Catalytic activity RHEA:58816: ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate
Pathway Cell wall biogenesis; peptidoglycan biosynthesis.
Subcellular location Cytoplasm.
Similarity Belongs to the MurCDEF family. MurD2 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0016881; Molecular function: acid-amino acid ligase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF08245; Mur_ligase_M; 1;
PF02875; Mur_ligase_C; 1;
NCBIfam TIGR01087; murD; 1;

Features [?]

From: MURD2_XANOM (Q2P5V2)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     122     128       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     G-[TS]-[KN]-G-K-[ST]-T  

Additional information [?]

Size range 400-500 amino acids
Related rules MF_00639 (MURD)
Fusion None