HAMAP rule MF_02208

General rule information [?]

Accession	MF_02208
Dates	21-JAN-2019 (Created) 1-JUN-2023 (Last updated, Version 6)

Name	MurD2_subfam

Scope

Bacteria

Templates

Q2P5V2 (MURD2_XANOM); C4RJF7 (MURD2_MICS3); A4X981 (MURD2_SALTO): [Recover all]

Triggered by

HAMAP; MF_02208 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

MURD2

Protein name

RecName:		Full=UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase;
		EC 6.3.2.53;
AltName:		Full=UDP-N-acetylmuramoyl-L-alanyl-L-glutamate synthetase;
		Short=UDP-MurNAc-L-Ala-L-Glu synthetase;

Gene name

murD2

Comments [?]

Function	Cell wall formation. Catalyzes the addition of L-glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine.
Catalytic activity	RHEA:58816: ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate EC 6.3.2.53
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis.
Subcellular location	Cytoplasm.
Similarity	Belongs to the MurCDEF family. MurD2 subfamily.

Keywords [?]

ATP-binding
Cell cycle
Cell division
Cell shape
Cell wall biogenesis/degradation
Cytoplasm
Ligase
Nucleotide-binding
Peptidoglycan synthesis

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0016881; Molecular function: acid-amino acid ligase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF08245; Mur_ligase_M; 1;
	PF02875; Mur_ligase_C; 1;
NCBIfam	TIGR01087; murD; 1;

Features [?]

From: MURD2_XANOM (Q2P5V2)

Key From To Description Tag Condition FTGroup

BINDING 122 128 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 G-[TS]-[KN]-G-K-[ST]-T

Additional information [?]

Size range	400-500 amino acids
Related rules	MF_00639 (MURD)
Fusion	None

View rule in raw text format (no links)