HAMAP logo

HAMAP rule MF_02211

Send feedback

General rule information [?]

Accession MF_02211
Dates 19-FEB-2019 (Created)
16-AUG-2023 (Last updated, Version 8)
Name MpaA_carboxypeptidase
Scope(s) Bacteria
Template(s) A7N805 (MPAA_VIBC1); P0ACV6 (MPAA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_02211 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MPAA
Protein name RecName: Full=Murein peptide amidase A;
AltName: Full=Gamma-D-Glu-Dap amidase;
AltName: Full=Zinc metallocarboxypeptidase MpaA;
Gene name Name=mpaA;

Comments [?]

FUNCTIONInvolved in muropeptide degradation. Catalyzes the hydrolysis of the gamma-D-glutamyl-diaminopimelic acid (gamma-D-Glu-Dap) amide bond in the murein tripeptide L-alanyl-gamma-D-glutamyl-meso- diaminopimelic acid, leading to the formation of L-Ala-gamma-D-Glu and Dap.
CATALYTIC ACTIVITY Reaction=H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate = L- alanyl-D-glutamate + meso-2,6-diaminoheptanedioate; Xref=Rhea:RHEA:28398, ChEBI:CHEBI:15377, ChEBI:CHEBI:57791, ChEBI:CHEBI:61395, ChEBI:CHEBI:61401;
case <FTGroup:1>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
end case
PATHWAYCell wall degradation; peptidoglycan degradation.
SIMILARITYBelongs to the peptidase M14 family.

Keywords [?]

Gene Ontology [?]

GO:0061473; Molecular function:murein tripeptide carboxypeptidase activity
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case
GO:0009253; Biological process:peptidoglycan catabolic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00246; Peptidase_M14; 1;

Features [?]

From: MPAA_VIBC1 (A7N805)
Key From To Description Tag Condition FTGroup
BINDING 60 60 /ligand="Zn(2+)"
H 1
BINDING 63 63 /ligand="Zn(2+)"
E 1
BINDING 168 168 /ligand="Zn(2+)"
H 1

Additional information [?]

Size range 220-280 amino acids
Related rules None
Fusion Nter: None Cter: None

View rule in raw text format (no links)