HAMAP rule MF_02211
General rule information
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Accession | MF_02211 |
Dates | 19-FEB-2019 (Created) 19-NOV-2022 (Last updated, Version 7) |
Name | MpaA_carboxypeptidase |
Scope | Bacteria; Gammaproteobacteria |
Templates | A7N805 (MPAA_VIBC1); P0ACV6 (MPAA_ECOLI): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Involved in muropeptide degradation. Catalyzes the hydrolysis of the gamma-D-glutamyl-diaminopimelic acid (gamma-D-Glu-Dap) amide bond in the murein tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid, leading to the formation of L-Ala-gamma-D-Glu and Dap. |
Catalytic activity | RHEA:28398: H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate = L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate |
case <FTGroup:1>
Cofactor | Zn(2+) Note: Binds 1 zinc ion per subunit. |
end case
Pathway | Cell wall degradation; peptidoglycan degradation. |
Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the peptidase M14 family. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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GO:0061473; Molecular function: murein tripeptide carboxypeptidase activity.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0009253; Biological process: peptidoglycan catabolic process.
GO:0005737; Cellular component: cytoplasm.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Pfam | PF00246; Peptidase_M14; 1; |
Features
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From: MPAA_VIBC1 (A7N805) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 60 | 60 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | H | 1 | |||||||
BINDING | 63 | 63 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | E | 1 | |||||||
BINDING | 168 | 168 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | H | 1 |
Additional information
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Size range | 220-280 amino acids |
Related rules | None |
Fusion | None |