HAMAP rule MF_02211

General rule information [?]

Accession	MF_02211
Dates	19-FEB-2019 (Created) 19-NOV-2022 (Last updated, Version 7)

Name	MpaA_carboxypeptidase

Scope

Bacteria; Gammaproteobacteria

Templates

A7N805 (MPAA_VIBC1); P0ACV6 (MPAA_ECOLI): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

MPAA

Protein name

RecName:		Full=Murein peptide amidase A;
		EC 3.4.17.-;
AltName:		Full=Gamma-D-Glu-Dap amidase;
AltName:		Full=Zinc metallocarboxypeptidase MpaA;

Gene name

mpaA

Comments [?]

Function	Involved in muropeptide degradation. Catalyzes the hydrolysis of the gamma-D-glutamyl-diaminopimelic acid (gamma-D-Glu-Dap) amide bond in the murein tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid, leading to the formation of L-Ala-gamma-D-Glu and Dap.
Catalytic activity	RHEA:28398: H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate = L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate

case <FTGroup:1>

Cofactor

Zn(2+)
Note: Binds 1 zinc ion per subunit.

end case

Pathway	Cell wall degradation; peptidoglycan degradation.
Subunit	Homodimer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the peptidase M14 family.

Keywords [?]

case <FTGroup:1>

end case

Gene Ontology [?]

GO:0061473; Molecular function: murein tripeptide carboxypeptidase activity.

case <FTGroup:1>

GO:0008270; Molecular function: zinc ion binding.

end case

GO:0009253; Biological process: peptidoglycan catabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF00246; Peptidase_M14; 1;

Features [?]

From: MPAA_VIBC1 (A7N805)

Key From To Description Tag Condition FTGroup

BINDING 60 60 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 H 1

BINDING 63 63 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 E 1

BINDING 168 168 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 H 1

Additional information [?]