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HAMAP rule MF_02211

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General rule information [?]

Accession MF_02211
Dates 19-FEB-2019 (Created)
19-NOV-2022 (Last updated, Version 7)
Name MpaA_carboxypeptidase
Bacteria; Gammaproteobacteria
Templates A7N805 (MPAA_VIBC1); P0ACV6 (MPAA_ECOLI): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Murein peptide amidase A;
EC 3.4.17.-;
AltName: Full=Gamma-D-Glu-Dap amidase;
AltName: Full=Zinc metallocarboxypeptidase MpaA;
Gene name

Comments [?]

Function Involved in muropeptide degradation. Catalyzes the hydrolysis of the gamma-D-glutamyl-diaminopimelic acid (gamma-D-Glu-Dap) amide bond in the murein tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid, leading to the formation of L-Ala-gamma-D-Glu and Dap.
Catalytic activity RHEA:28398: H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate = L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate
case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
end case
Pathway Cell wall degradation; peptidoglycan degradation.
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the peptidase M14 family.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0061473; Molecular function: murein tripeptide carboxypeptidase activity.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0009253; Biological process: peptidoglycan catabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00246; Peptidase_M14; 1;

Features [?]

From: MPAA_VIBC1 (A7N805)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     60     60       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     H   1
BINDING     63     63       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     E   1
BINDING     168     168       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     H   1

Additional information [?]

Size range 220-280 amino acids
Related rules None
Fusion None