HAMAP rule MF_02211
General rule information
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Accession | MF_02211 |
Dates | 19-FEB-2019 (Created)
19-NOV-2022 (Last updated, Version 7) |
Name | MpaA_carboxypeptidase |
Scope(s) |
Bacteria Gammaproteobacteria |
Template(s) | A7N805 (MPAA_VIBC1); P0ACV6 (MPAA_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_02211 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MPAA |
Protein name | RecName: Full=Murein peptide amidase A; EC=3.4.17.-; AltName: Full=Gamma-D-Glu-Dap amidase; AltName: Full=Zinc metallocarboxypeptidase MpaA; |
Gene name | Name=mpaA; |
Comments
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FUNCTION | Involved in muropeptide degradation. Catalyzes the hydrolysis of the gamma-D-glutamyl-diaminopimelic acid (gamma-D-Glu-Dap) amide bond in the murein tripeptide L-alanyl-gamma-D-glutamyl-meso- diaminopimelic acid, leading to the formation of L-Ala-gamma-D-Glu and Dap. |
CATALYTIC ACTIVITY | Reaction=H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate = L- alanyl-D-glutamate + meso-2,6-diaminoheptanedioate; Xref=Rhea:RHEA:28398, ChEBI:CHEBI:15377, ChEBI:CHEBI:57791, ChEBI:CHEBI:61395, ChEBI:CHEBI:61401; |
case <FTGroup:1> | |
COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
end case | |
PATHWAY | Cell wall degradation; peptidoglycan degradation. |
SUBUNIT | Homodimer. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the peptidase M14 family. |
Keywords
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Carboxypeptidase | |
Cell wall biogenesis/degradation | |
Cytoplasm | |
Hydrolase | |
Metalloprotease | |
Protease | |
case <FTGroup:1> | |
Metal-binding | |
Zinc | |
end case |
Gene Ontology
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GO:0061473; Molecular function:murein tripeptide carboxypeptidase activity | |
case <FTGroup:1> | |
GO:0008270; Molecular function:zinc ion binding | |
end case | |
GO:0009253; Biological process:peptidoglycan catabolic process | |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Pfam | PF00246; Peptidase_M14; 1; |
Features
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From: MPAA_VIBC1 (A7N805) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 60 | 60 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 | |||||||
BINDING | 63 | 63 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
E | 1 | |||||||
BINDING | 168 | 168 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 |
Additional information
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Size range | 220-280 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |