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| Annotation rule MF_02211 |
General rule information
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| Accession | MF_02211 |
| Dates | 19-FEB-2019 (Created) 21-JAN-2020 (Last updated, Version 4) |
| Name | MpaA_carboxypeptidase |
| Scope | Bacteria; Gammaproteobacteria |
| Templates | A7N805 (MPAA_VIBCB); P0ACV6 (MPAA_ECOLI): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Involved in muropeptide degradation. Catalyzes the hydrolysis of the gamma-D-glutamyl-diaminopimelic acid (gamma-D-Glu-Dap) amide bond in the murein tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid, leading to the formation of L-Ala-gamma-D-Glu and Dap. |
| Catalytic activity | RHEA:28398: H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate = L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate |
case <FTGroup:1>
| Cofactor | Zn(2+) Note: Binds 1 zinc ion per subunit. |
end case
| Pathway | Cell wall degradation; peptidoglycan degradation. |
| Subunit | Homodimer. |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the peptidase M14 family. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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GO:0061473; Molecular function: murein tripeptide carboxypeptidase activity.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0009253; Biological process: peptidoglycan catabolic process.
GO:0005737; Cellular component: cytoplasm.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| Pfam | PF00246; Peptidase_M14; 1; |
Features
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| From: MPAA_VIBCB (A7N805) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| METAL | 60 | 60 | Zinc; via pros nitrogen | H | 1 | |||||||
| METAL | 63 | 63 | Zinc | E | 1 | |||||||
| METAL | 168 | 168 | Zinc; via pros nitrogen | H | 1 | |||||||
Additional information
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| Size range | 220-280 amino acids |
| Related rules | None |
| Fusion | None |