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Annotation rule MF_02213 |
Accession | MF_02213 |
Dates | 7-MAR-2019 (Created) 20-NOV-2019 (Last updated, Version 3) |
Name | Lipid_II_synth_GatD |
Scope | Bacteria
Archaea |
Templates | A0A0H2WZ38 (GATD_STAAC); A0A0H3JN63 (GATD_STAAN); Q8DNZ8 (GATD_STRR6): [Recover all] |
Triggered by |
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Protein name |
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Gene name |
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Function | The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT. |
Catalytic activity | RHEA:57928: ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + H(+) + L-glutamate + phosphate
EC 6.3.5.13 |
RHEA:15889: H2O + L-glutamine = L-glutamate + NH4(+)
EC 3.5.1.2 |
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Pathway | Cell wall biogenesis; peptidoglycan biosynthesis. |
Subunit | Forms a heterodimer with MurT. |
Similarity | Belongs to the CobB/CobQ family. GatD subfamily. |
From: GATD_STAAC (A0A0H2WZ38) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 94 | 94 | Nucleophile | C | ||||||||
ACT_SITE | 189 | 189 | H | |||||||||
BINDING | 128 | 128 | Substrate | R |
Size range | 210-390 amino acids |
Related rules | None |
Fusion | None |