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Annotation rule MF_02217
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General rule information [?]

Accession MF_02217
Dates 11-JUN-2019 (Created)
20-NOV-2019 (Last updated, Version 2)
Name TrmR_methyltr
Scope
Bacteria
Template O32036 (TRMR_BACSU)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TRMR
Protein name
RecName: Full=tRNA 5-hydroxyuridine methyltransferase;
EC 2.1.1.-;
AltName: Full=ho5U methyltransferase;
Gene name
trmR

Comments [?]

Function Catalyzes the methylation of 5-hydroxyuridine (ho5U) to form 5-methoxyuridine (mo5U) at position 34 in tRNAs.
Catalytic activity RHEA:60524: 5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine
Subunit Homodimer.
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0016300; Molecular function: tRNA (uracil) methyltransferase activity.
case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
GO:0030488; Biological process: tRNA methylation.

Cross-references [?]

PROSITE PS51682; SAM_OMT_I; 1;
Pfam PF01596; Methyltransf_3; 1;

Features [?]

From: TRMR_BACSU (O32036)
Key     From     To       Description   Tag   Condition   FTGroup
REGION (Optional)     113     114       S-adenosyl-L-methionine binding     [DE]-A  
METAL (Optional)     133     133       Magnesium     D   1
METAL (Optional)     159     159       Magnesium     D   1
METAL (Optional)     160     160       Magnesium     N   1
BINDING (Optional)     38     38       S-adenosyl-L-methionine; via amide nitrogen     [MVIL]  
BINDING (Optional)     68     68       S-adenosyl-L-methionine     S  
BINDING (Optional)     85     85       S-adenosyl-L-methionine     [ED]  
BINDING (Optional)     133     133       S-adenosyl-L-methionine     D  

Additional information [?]

Size range 190-270 amino acids
Related rules None
Fusion None