HAMAP rule MF_02217
General rule information
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Accession | MF_02217 |
Dates | 11-JUN-2019 (Created)
13-OCT-2023 (Last updated, Version 6) |
Name | TrmR_methyltr |
Scope(s) |
Bacteria |
Template(s) | O32036 (TRMR_BACSU); [ Recover all ] |
Triggered by |
HAMAP; MF_02217 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | TRMR |
Protein name | RecName: Full=tRNA 5-hydroxyuridine methyltransferase; EC=2.1.1.-; AltName: Full=ho5U methyltransferase; |
Gene name | Name=trmR; |
Comments
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FUNCTION | Catalyzes the methylation of 5-hydroxyuridine (ho5U) to form 5-methoxyuridine (mo5U) at position 34 in tRNAs. |
CATALYTIC ACTIVITY | Reaction=5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5- methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60524, Rhea:RHEA-COMP:13381, Rhea:RHEA-COMP:15591, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:136877, ChEBI:CHEBI:143860; |
SUBUNIT | Homodimer. |
SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. |
Keywords
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Methyltransferase | |
S-adenosyl-L-methionine | |
Transferase | |
tRNA processing | |
case <FTGroup:1> | |
Magnesium | |
Metal-binding | |
end case |
Gene Ontology
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GO:0016300; Molecular function:tRNA (uridine) methyltransferase activity | |
case <FTGroup:1> | |
GO:0000287; Molecular function:magnesium ion binding | |
end case | |
GO:0030488; Biological process:tRNA methylation |
Cross-references
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Features
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From: TRMR_BACSU (O32036) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 113 | 114 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[DE]-A | ||||||||
BINDING | 133 | 133 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | 1 | |||||||
BINDING | 159 | 159 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | 1 | |||||||
BINDING | 160 | 160 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
N | 1 | |||||||
BINDING | 38 | 38 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[MVIL] | ||||||||
BINDING | 68 | 68 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
S | ||||||||
BINDING | 85 | 85 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[ED] | ||||||||
BINDING | 133 | 133 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D |
Additional information
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Size range | 190-270 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |