HAMAP rule MF_02217

General rule information [?]

Accession	MF_02217
Dates	11-JUN-2019 (Created) 19-NOV-2022 (Last updated, Version 5)

Name	TrmR_methyltr

Scope

Bacteria

Template

O32036 (TRMR_BACSU)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

TRMR

Protein name

RecName:		Full=tRNA 5-hydroxyuridine methyltransferase;
		EC 2.1.1.-;
AltName:		Full=ho5U methyltransferase;

Gene name

trmR

Comments [?]

Function	Catalyzes the methylation of 5-hydroxyuridine (ho5U) to form 5-methoxyuridine (mo5U) at position 34 in tRNAs.
Catalytic activity	RHEA:60524: 5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine
Subunit	Homodimer.
Similarity	Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

Keywords [?]

case <FTGroup:1>

end case

Gene Ontology [?]

GO:0016300; Molecular function: tRNA (uracil) methyltransferase activity.

case <FTGroup:1>

GO:0000287; Molecular function: magnesium ion binding.

end case

GO:0030488; Biological process: tRNA methylation.

Cross-references [?]

PROSITE	PS51682; SAM_OMT_I; 1;
Pfam	PF01596; Methyltransf_3; 1;

Features [?]

From: TRMR_BACSU (O32036)

Key From To Description Tag Condition FTGroup

BINDING (Optional) 113 114 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 [DE]-A

BINDING (Optional) 133 133 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 D 1

BINDING (Optional) 159 159 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 D 1

BINDING (Optional) 160 160 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 N 1

BINDING (Optional) 38 38 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 [MVIL]

BINDING (Optional) 68 68 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 S

BINDING (Optional) 85 85 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 [ED]

BINDING (Optional) 133 133 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 D

Additional information [?]