HAMAP rule MF_02217
General rule information
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Accession | MF_02217 |
Dates | 11-JUN-2019 (Created) 19-NOV-2022 (Last updated, Version 5) |
Name | TrmR_methyltr |
Scope | Bacteria |
Template | O32036 (TRMR_BACSU) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the methylation of 5-hydroxyuridine (ho5U) to form 5-methoxyuridine (mo5U) at position 34 in tRNAs. |
Catalytic activity | RHEA:60524: 5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine |
Subunit | Homodimer. |
Similarity | Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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GO:0016300; Molecular function: tRNA (uracil) methyltransferase activity.
case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
GO:0030488; Biological process: tRNA methylation.
Cross-references
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Features
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From: TRMR_BACSU (O32036) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 113 | 114 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [DE]-A | ||||||||
BINDING (Optional) | 133 | 133 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | D | 1 | |||||||
BINDING (Optional) | 159 | 159 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | D | 1 | |||||||
BINDING (Optional) | 160 | 160 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | N | 1 | |||||||
BINDING (Optional) | 38 | 38 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [MVIL] | ||||||||
BINDING (Optional) | 68 | 68 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | S | ||||||||
BINDING (Optional) | 85 | 85 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [ED] | ||||||||
BINDING (Optional) | 133 | 133 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | D |
Additional information
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Size range | 190-270 amino acids |
Related rules | None |
Fusion | None |