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Annotation rule MF_02218
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General rule information [?]

Accession MF_02218
Dates 14-JUN-2019 (Created)
20-NOV-2019 (Last updated, Version 2)
Name GlcN_kinase
Bacteria; Actinobacteria
Templates A0A1H7TQR5 (GLCNK_STRJI); I7FJX8 (GLCNK_MYCS2): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Glucosamine kinase;
Short=GlcN kinase;

Comments [?]

Function Catalyzes the ATP-dependent phosphorylation of D-glucosamine (GlcN) to D-glucosamine 6-phosphate. May be involved in the phosphorylation of acquired extracellular GlcN derived from the hydrolysis of chitosan, i.e., in the incorporation of exogenous GlcN into the bacterial GlcNAc metabolism.
Catalytic activity RHEA:10948: ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate + H(+)
Cofactor Mg(2+)
Note: Binds 2 Mg(2+) ions per subunit
Subunit Monomer.
Similarity Belongs to the actinobacterial glucosamine kinase family.

Keywords [?]

Gene Ontology [?]

GO:0047931; Molecular function: glucosamine kinase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0005975; Biological process: carbohydrate metabolic process.

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND (Optional)     186     188       ATP     [AGST]-x-[LIV]  
MOTIF (Optional)     405     420       Substrate specificity determinant motif     Q-x(2)-R-E-x(2)-Y-A-x(3)-L-P-x-W  
METAL     305     305       Magnesium 1     Q  
METAL     317     317       Magnesium 1     D  
METAL     317     317       Magnesium 2     D  
METAL     319     319       Magnesium 2     D  
BINDING (Optional)     133     133       ATP     K  
BINDING (Optional)     193     193       ATP     D  
BINDING (Optional)     300     300       D-glucosamine     D  
BINDING (Optional)     409     409       D-glucosamine     E  

Additional information [?]

Size range 300-440 amino acids
Related rules None
Fusion None