HAMAP rule MF_02218
General rule information
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| Accession | MF_02218 |
| Dates | 14-JUN-2019 (Created)
13-JAN-2023 (Last updated, Version 5) |
| Name | GlcN_kinase |
| Scope(s) |
Bacteria Actinomycetota |
| Template(s) | A0A1H7TQR5 (GLCNK_STRJI); I7FJX8 (GLCNK_MYCS2); [ Recover all ] |
| Triggered by |
HAMAP; MF_02218 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GLCNK |
| Protein name | RecName: Full=Glucosamine kinase; Short=GlcN kinase; Short=GlcNK; EC=2.7.1.8; |
Comments
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| FUNCTION | Catalyzes the ATP-dependent phosphorylation of D-glucosamine (GlcN) to D-glucosamine 6-phosphate. May be involved in the phosphorylation of acquired extracellular GlcN derived from the hydrolysis of chitosan, i.e., in the incorporation of exogenous GlcN into the bacterial GlcNAc metabolism. |
| CATALYTIC ACTIVITY | Reaction=ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate + H(+); Xref=Rhea:RHEA:10948, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58723, ChEBI:CHEBI:58725, ChEBI:CHEBI:456216; EC=2.7.1.8; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 Mg(2+) ions per subunit |
| SUBUNIT | Monomer. |
| SIMILARITY | Belongs to the actinobacterial glucosamine kinase family. |
Keywords
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Gene Ontology
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| GO:0047931; Molecular function:glucosamine kinase activity |
| GO:0000287; Molecular function:magnesium ion binding |
| GO:0005975; Biological process:carbohydrate metabolic process |
Cross-references
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Features
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| From: GLCNK_STRJI (A0A1H7TQR5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 186 | 188 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[AGST]-x-[LIV] | ||||||||
| MOTIF | 405 | 420 | /note="Substrate specificity determinant motif" | Q-x(2)-R-E-x(2)-Y-A-x(3)-L-P-x-W | ||||||||
| BINDING | 305 | 305 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
Q | ||||||||
| BINDING | 317 | 317 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
D | ||||||||
| BINDING | 317 | 317 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
D | ||||||||
| BINDING | 319 | 319 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
D | ||||||||
| BINDING | 133 | 133 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
K | ||||||||
| BINDING | 193 | 193 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
D | ||||||||
| BINDING | 300 | 300 | /ligand="D-glucosamine" /ligand_id="ChEBI:CHEBI:58723" |
D | ||||||||
| BINDING | 409 | 409 | /ligand="D-glucosamine" /ligand_id="ChEBI:CHEBI:58723" |
E | ||||||||
Additional information
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| Size range | 300-440 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |