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Annotation rule MF_02221 |
Accession | MF_02221 |
Dates | 6-AUG-2019 (Created) 20-NOV-2019 (Last updated, Version 2) |
Name | CPSase |
Scope | Archaea; Methanobacteria
Archaea; Methanopyri |
Template | A5UK38 (CPS_METS3) |
Triggered by |
Identifier |
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Protein name |
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Function | Catalyzes the synthesis of carbamoyl phosphate from ATP, ammonium and bicarbonate. Proceeds via a three-step mechanism, i.e. the phosphorylation of hydrogencarbonate to carboxyphosphate, a nucleophilic attack of ammonia on carboxyphosphate yielding carbamate, and the phosphorylation of carbamate forming carbamoyl phosphate. |
Catalytic activity | RHEA:18029: 2 ATP + hydrogencarbonate + NH4(+) = 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate
EC 6.3.4.16 PhysiologicalDirection=left-to-right (RHEA:18030) |
Cofactor | Mg(2+) Mn(2+) Note: Binds 2 magnesium or manganese ions per subunit |
Similarity | Belongs to the small carbamoyl-phosphate synthase family. |
From: CPS_METS3 (A5UK38) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND | 137 | 186 | ATP |
Size range | 338-480 amino acids |
Related rules | None |
Fusion | None |