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HAMAP rule MF_02221

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General rule information [?]

Accession MF_02221
Dates 6-AUG-2019 (Created)
19-NOV-2022 (Last updated, Version 4)
Name CPSase
Scope(s) Archaea
Template(s) A5UK38 (CPS_METS3); [ Recover all ]
Triggered by HAMAP; MF_02221 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CPS
Protein name RecName: Full=Carbamoyl-phosphate synthase;
AltName: Full=Carbamoyl phosphate synthetase;

Comments [?]

FUNCTIONCatalyzes the synthesis of carbamoyl phosphate from ATP, ammonium and bicarbonate. Proceeds via a three-step mechanism, i.e. the phosphorylation of hydrogencarbonate to carboxyphosphate, a nucleophilic attack of ammonia on carboxyphosphate yielding carbamate, and the phosphorylation of carbamate forming carbamoyl phosphate.
CATALYTIC ACTIVITY Reaction=2 ATP + hydrogencarbonate + NH4(+) = 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate; Xref=Rhea:RHEA:18029, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:28938, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58228, ChEBI:CHEBI:456216; EC=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18030;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 magnesium or manganese ions per subunit
SIMILARITYBelongs to the small carbamoyl-phosphate synthase family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0004087; Molecular function:carbamoyl-phosphate synthase (ammonia) activity
GO:0000287; Molecular function:magnesium ion binding
GO:0030145; Molecular function:manganese ion binding

Cross-references [?]

Pfam PF02655; ATP-grasp_3; 1;

Features [?]

From: CPS_METS3 (A5UK38)
Key From To Description Tag Condition FTGroup
BINDING 137 186 /ligand="ATP"

Additional information [?]

Size range 338-480 amino acids
Related rules None
Fusion Nter: None Cter: None

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