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Annotation rule MF_02224
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General rule information [?]

Accession MF_02224
Dates 20-AUG-2019 (Created)
20-NOV-2019 (Last updated, Version 2)
Name PPS
Scope
Archaea
Templates Q5JIZ8 (PPS_THEKO); Q2FUA9 (PPS_METHJ); B6YXQ1 (PPS_THEON): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PPS
Protein name
RecName: Full=4-phosphopantoate--beta-alanine ligase;
EC 6.3.2.36;
AltName: Full=Phosphopantothenate synthetase;
Short=PPS;

Comments [?]

Function Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
Catalytic activity RHEA:27930: (R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)
EC 6.3.2.36
Pathway Cofactor biosynthesis; coenzyme A biosynthesis.
Subunit Homodimer.
Similarity Belongs to the archaeal phosphopantothenate synthetase family.

Keywords [?]

ATP-binding
Coenzyme A biosynthesis
Ligase
Nucleotide-binding

Gene Ontology [?]

GO:0016881; Molecular function: acid-amino acid ligase activity.
GO:0015937; Biological process: coenzyme A biosynthetic process.

Cross-references [?]

Pfam PF02006; PPS_PS; 1;
PIRSF PIRSF004853; UCP004853; 1;

Features [?]

From: PPS_THEKO (Q5JIZ8)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND (Optional)     181     183       ATP     D-[LI]-N  
NP_BIND (Optional)     187     188       ATP     R-[ST]  
NP_BIND (Optional)     199     200       ATP     N-[ILV]  
BINDING (Optional)     17     17       ATP     R  
BINDING (Optional)     39     39       ATP     R  

Additional information [?]

Size range 230-310 amino acids
Related rules None
Fusion None


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