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HAMAP rule MF_02224

General rule information [?]

Accession	MF_02224
Dates	20-AUG-2019 (Created) 19-NOV-2022 (Last updated, Version 4)
Name	PPS
Scope(s)	Archaea
Template(s)	Q5JIZ8 (PPS_THEKO); Q2FUA9 (PPS_METHJ); B6YXQ1 (PPS_THEON); [ Recover all ]
Triggered by	HAMAP; MF_02224 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	PPS
Protein name	RecName: Full=4-phosphopantoate--beta-alanine ligase; EC=6.3.2.36; AltName: Full=Phosphopantothenate synthetase; Short=PPS;

Comments [?]

FUNCTION	Catalyzes the condensation of (R)-4-phosphopantoate and beta- alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
CATALYTIC ACTIVITY	Reaction=(R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'- phosphopantothenate + AMP + diphosphate + H(+); Xref=Rhea:RHEA:27930, ChEBI:CHEBI:10986, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57966, ChEBI:CHEBI:61294, ChEBI:CHEBI:456215; EC=6.3.2.36;
PATHWAY	Cofactor biosynthesis; coenzyme A biosynthesis.
SUBUNIT	Homodimer.
SIMILARITY	Belongs to the archaeal phosphopantothenate synthetase family.

Keywords [?]

Gene Ontology [?]

GO:0016881; Molecular function:acid-amino acid ligase activity

GO:0015937; Biological process:coenzyme A biosynthetic process

Cross-references [?]

Pfam	PF02006; PPS_PS; 1;
PIRSF	PIRSF004853; UCP004853; 1;

Features [?]

From: PPS_THEKO (Q5JIZ8)

Key

From

Description

Tag

Condition

FTGroup

BINDING

181

183