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HAMAP rule MF_02224

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General rule information [?]

Accession MF_02224
Dates 20-AUG-2019 (Created)
19-NOV-2022 (Last updated, Version 4)
Name PPS
Scope(s) Archaea
Template(s) Q5JIZ8 (PPS_THEKO); Q2FUA9 (PPS_METHJ); B6YXQ1 (PPS_THEON); [ Recover all ]
Triggered by HAMAP; MF_02224 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PPS
Protein name RecName: Full=4-phosphopantoate--beta-alanine ligase;
AltName: Full=Phosphopantothenate synthetase;

Comments [?]

FUNCTIONCatalyzes the condensation of (R)-4-phosphopantoate and beta- alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
CATALYTIC ACTIVITY Reaction=(R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'- phosphopantothenate + AMP + diphosphate + H(+); Xref=Rhea:RHEA:27930, ChEBI:CHEBI:10986, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57966, ChEBI:CHEBI:61294, ChEBI:CHEBI:456215; EC=;
PATHWAYCofactor biosynthesis; coenzyme A biosynthesis.
SIMILARITYBelongs to the archaeal phosphopantothenate synthetase family.

Keywords [?]

Gene Ontology [?]

GO:0016881; Molecular function:acid-amino acid ligase activity
GO:0015937; Biological process:coenzyme A biosynthetic process

Cross-references [?]

Pfam PF02006; PPS_PS; 1;
PIRSF PIRSF004853; UCP004853; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 181 183 /ligand="ATP"
BINDING 187 188 /ligand="ATP"
BINDING 199 200 /ligand="ATP"
BINDING 17 17 /ligand="ATP"
BINDING 39 39 /ligand="ATP"

Additional information [?]

Size range 230-310 amino acids
Related rules None
Fusion Nter: None Cter: None

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