HAMAP rule MF_02224
General rule information
[?]
Accession | MF_02224 |
Dates | 20-AUG-2019 (Created) 19-NOV-2022 (Last updated, Version 4) |
Name | PPS |
Scope | Archaea |
Templates | Q5JIZ8 (PPS_THEKO); Q2FUA9 (PPS_METHJ); B6YXQ1 (PPS_THEON): [Recover all] |
Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier |
|
Protein name |
|
Comments
[?]
Function | Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway. |
Catalytic activity | RHEA:27930: (R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)
EC 6.3.2.36 |
Pathway | Cofactor biosynthesis; coenzyme A biosynthesis. |
Subunit | Homodimer. |
Similarity | Belongs to the archaeal phosphopantothenate synthetase family. |
Keywords
[?]
Gene Ontology
[?]
GO:0016881; Molecular function: acid-amino acid ligase activity.
GO:0015937; Biological process: coenzyme A biosynthetic process.
GO:0015937; Biological process: coenzyme A biosynthetic process.
Cross-references
[?]
Pfam | PF02006; PPS_PS; 1; |
PIRSF | PIRSF004853; UCP004853; 1; |
Features
[?]
From: PPS_THEKO (Q5JIZ8) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 181 | 183 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | D-[LI]-N | ||||||||
BINDING (Optional) | 187 | 188 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | R-[ST] | ||||||||
BINDING (Optional) | 199 | 200 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | N-[ILV] | ||||||||
BINDING (Optional) | 17 | 17 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | R | ||||||||
BINDING (Optional) | 39 | 39 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | R |
Additional information
[?]
Size range | 230-310 amino acids |
Related rules | None |
Fusion | None |