HAMAP rule MF_02224

General rule information [?]

Accession	MF_02224
Dates	20-AUG-2019 (Created) 19-NOV-2022 (Last updated, Version 4)

Name

PPS

Scope

Archaea

Templates

Q5JIZ8 (PPS_THEKO); Q2FUA9 (PPS_METHJ); B6YXQ1 (PPS_THEON): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

PPS

Protein name

RecName:		Full=4-phosphopantoate--beta-alanine ligase;
		EC 6.3.2.36;
AltName:		Full=Phosphopantothenate synthetase;
		Short=PPS;

Comments [?]

Function	Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
Catalytic activity	RHEA:27930: (R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'-phosphopantothenate + AMP + diphosphate + H(+) EC 6.3.2.36
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis.
Subunit	Homodimer.
Similarity	Belongs to the archaeal phosphopantothenate synthetase family.

Keywords [?]

Gene Ontology [?]

GO:0016881; Molecular function: acid-amino acid ligase activity.
GO:0015937; Biological process: coenzyme A biosynthetic process.

Cross-references [?]

Pfam	PF02006; PPS_PS; 1;
PIRSF	PIRSF004853; UCP004853; 1;

Features [?]

From: PPS_THEKO (Q5JIZ8)

Key From To Description Tag Condition FTGroup

BINDING (Optional) 181 183 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 D-[LI]-N

BINDING (Optional) 187 188 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 R-[ST]

BINDING (Optional) 199 200 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 N-[ILV]

BINDING (Optional) 17 17 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 R

BINDING (Optional) 39 39 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 R

Additional information [?]