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Annotation rule MF_02225 |
Accession | MF_02225 |
Dates | 23-AUG-2019 (Created) 20-NOV-2019 (Last updated, Version 2) |
Name | CoaBC |
Scope | Bacteria
Archaea |
Templates | P0ABQ0 (COABC_ECOLI); Q58323 (COABC_METJA); Q5JF17 (COABC_THEKO): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine. |
Catalytic activity | RHEA:16793: H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = CO2 + D-pantetheine 4'-phosphate
EC 4.1.1.36 |
RHEA:19397: (R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine
EC 6.3.2.5 |
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Cofactor | Mg(2+) |
FMN Note: Binds 1 FMN per subunit. |
Pathway | Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5. |
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5. |
Pathway | Cofactor biosynthesis; coenzyme A biosynthesis. |
Similarity | In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily. |
In the C-terminal section; belongs to the PPC synthetase family. |
From: COABC_ECOLI (P0ABQ0) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND (Optional) | 273 | 275 | CTP | G-C-A | ||||||||
NP_BIND (Optional) | 308 | 311 | CTP | P-D-[ILVM]-[VLI] | ||||||||
REGION | Nter | 190 | Phosphopantothenoylcysteine decarboxylase | |||||||||
REGION | 191 | Cter | Phosphopantothenate--cysteine ligase | |||||||||
ACT_SITE (Optional) | 158 | 158 | Proton donor | C | ||||||||
BINDING (Optional) | 279 | 279 | CTP | D | ||||||||
BINDING (Optional) | 289 | 289 | CTP | K | ||||||||
BINDING (Optional) | 327 | 327 | CTP; via amide nitrogen | F | ||||||||
BINDING (Optional) | 341 | 341 | CTP | K | ||||||||
BINDING (Optional) | 345 | 345 | CTP | K |
Size range | 330-500 amino acids |
Related rules | None |
Fusion | None |