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Annotation rule MF_02225
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General rule information [?]

Accession MF_02225
Dates 23-AUG-2019 (Created)
20-NOV-2019 (Last updated, Version 2)
Name CoaBC
Scope
Bacteria
Archaea
Templates P0ABQ0 (COABC_ECOLI); Q58323 (COABC_METJA); Q5JF17 (COABC_THEKO): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
COABC
Protein name
RecName: Full=Coenzyme A biosynthesis bifunctional protein CoaBC;
AltName: Full=DNA/pantothenate metabolism flavoprotein;
AltName: Full=Phosphopantothenoylcysteine synthetase/decarboxylase;
Short=PPCS-PPCDC;
Includes:
RecName: Full=Phosphopantothenoylcysteine decarboxylase;
Short=PPC decarboxylase;
Short=PPC-DC;
EC 4.1.1.36;
AltName: Full=CoaC;
Includes:
RecName: Full=Phosphopantothenate--cysteine ligase;
EC 6.3.2.5;
AltName: Full=CoaB;
AltName: Full=Phosphopantothenoylcysteine synthetase;
Short=PPC synthetase;
Short=PPC-S;
Gene name
coaBC

Comments [?]

Function Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
Catalytic activity RHEA:16793: H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = CO2 + D-pantetheine 4'-phosphate
EC 4.1.1.36
RHEA:19397: (R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine
EC 6.3.2.5
Cofactor Mg(2+)
FMN
Note: Binds 1 FMN per subunit.
case <OC:Bacteria>
Pathway Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.
else case <OC:Archaea>
Pathway Cofactor biosynthesis; coenzyme A biosynthesis.
end case
Similarity In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
In the C-terminal section; belongs to the PPC synthetase family.

Keywords [?]

Decarboxylase
Flavoprotein
FMN
Ligase
Lyase
Magnesium
Metal-binding
Multifunctional enzyme

Gene Ontology [?]

GO:0010181; Molecular function: FMN binding.
GO:0004632; Molecular function: phosphopantothenate--cysteine ligase activity.
GO:0004633; Molecular function: phosphopantothenoylcysteine decarboxylase activity.
GO:0015937; Biological process: coenzyme A biosynthetic process.

Cross-references [?]

Pfam PF04127; DFP; 1;
PF02441; Flavoprotein; 1;
TIGRFAMs TIGR00521; coaBC_dfp; 1;

Features [?]

From: COABC_ECOLI (P0ABQ0)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND (Optional)     273     275       CTP     G-C-A  
NP_BIND (Optional)     308     311       CTP     P-D-[ILVM]-[VLI]  
REGION     Nter     190       Phosphopantothenoylcysteine decarboxylase        
REGION     191     Cter       Phosphopantothenate--cysteine ligase        
ACT_SITE (Optional)     158     158       Proton donor     C  
BINDING (Optional)     279     279       CTP     D  
BINDING (Optional)     289     289       CTP     K  
BINDING (Optional)     327     327       CTP; via amide nitrogen     F  
BINDING (Optional)     341     341       CTP     K  
BINDING (Optional)     345     345       CTP     K  

Additional information [?]

Size range 330-500 amino acids
Related rules None
Fusion None


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