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HAMAP rule MF_02226

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General rule information [?]

Accession MF_02226
Dates 18-SEP-2019 (Created)
19-NOV-2022 (Last updated, Version 5)
Name AlluloseP_3_epimer
Scope(s) Bacteria
Template(s) P32719 (ALSE_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_02226 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ALSE
case <OC:Enterobacterales>
Protein name RecName: Full=D-allulose-6-phosphate 3-epimerase;
Gene name Name=alsE;
Protein name RecName: Full=Putative D-allulose-6-phosphate 3-epimerase;
end case

Comments [?]

FUNCTIONCatalyzes the reversible epimerization of D-allulose 6- phosphate to D-fructose 6-phosphate. Can also catalyze with lower efficiency the reversible epimerization of D-ribulose 5-phosphate to D- xylulose 5-phosphate.
CATALYTIC ACTIVITY Reaction=D-allulose 6-phosphate = keto-D-fructose 6-phosphate; Xref=Rhea:RHEA:28426, ChEBI:CHEBI:57579, ChEBI:CHEBI:61519;
COFACTOR Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
PATHWAYCarbohydrate degradation; D-allose degradation.
SIMILARITYBelongs to the ribulose-phosphate 3-epimerase family. AlsE subfamily.

Keywords [?]

Gene Ontology [?]

GO:0034700; Molecular function:allulose 6-phosphate 3-epimerase activity
GO:0046872; Molecular function:metal ion binding
GO:0019316; Biological process:D-allose catabolic process

Cross-references [?]

Pfam PF00834; Ribul_P_3_epim; 1;

Features [?]

From: ALSE_ECOLI (P32719)
Key From To Description Tag Condition FTGroup
BINDING 140 143 /ligand="substrate" G-[FY]-[AT]-G
BINDING 173 175 /ligand="substrate" D-G-S
BINDING 195 197 /ligand="substrate" G-[TS]-S
ACT_SITE 32 32 /note="Proton acceptor" D
ACT_SITE 173 173 /note="Proton donor" D
BINDING 30 30 /ligand="a divalent metal cation"
H 1
BINDING 32 32 /ligand="a divalent metal cation"
D 1
BINDING 63 63 /ligand="a divalent metal cation"
H 1
BINDING 173 173 /ligand="a divalent metal cation"
D 1
BINDING 6 6 /ligand="substrate" S
BINDING 63 63 /ligand="substrate" H

Additional information [?]

Size range 210-260 amino acids
Related rules None
Fusion Nter: None Cter: None

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