HAMAP rule MF_02226
General rule information
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| Accession | MF_02226 |
| Dates | 18-SEP-2019 (Created)
19-NOV-2022 (Last updated, Version 5) |
| Name | AlluloseP_3_epimer |
| Scope(s) |
Bacteria |
| Template(s) | P32719 (ALSE_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_02226 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ALSE |
| case <OC:Enterobacterales> | |
| Protein name | RecName: Full=D-allulose-6-phosphate 3-epimerase; EC=5.1.3.-; |
| Gene name | Name=alsE; |
| else | |
| Protein name | RecName: Full=Putative D-allulose-6-phosphate 3-epimerase; EC=5.1.3.-; |
| end case | |
Comments
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| FUNCTION | Catalyzes the reversible epimerization of D-allulose 6- phosphate to D-fructose 6-phosphate. Can also catalyze with lower efficiency the reversible epimerization of D-ribulose 5-phosphate to D- xylulose 5-phosphate. |
| CATALYTIC ACTIVITY | Reaction=D-allulose 6-phosphate = keto-D-fructose 6-phosphate; Xref=Rhea:RHEA:28426, ChEBI:CHEBI:57579, ChEBI:CHEBI:61519; |
| COFACTOR | Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; |
| PATHWAY | Carbohydrate degradation; D-allose degradation. |
| SIMILARITY | Belongs to the ribulose-phosphate 3-epimerase family. AlsE subfamily. |
Keywords
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Gene Ontology
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| GO:0034700; Molecular function:allulose 6-phosphate 3-epimerase activity |
| GO:0046872; Molecular function:metal ion binding |
| GO:0019316; Biological process:D-allose catabolic process |
Cross-references
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| PROSITE | PS01085; RIBUL_P_3_EPIMER_1; 1; |
| PROSITE | PS01086; RIBUL_P_3_EPIMER_2; 1; |
| Pfam | PF00834; Ribul_P_3_epim; 1; |
Features
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| From: ALSE_ECOLI (P32719) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 140 | 143 | /ligand="substrate" | G-[FY]-[AT]-G | ||||||||
| BINDING | 173 | 175 | /ligand="substrate" | D-G-S | ||||||||
| BINDING | 195 | 197 | /ligand="substrate" | G-[TS]-S | ||||||||
| ACT_SITE | 32 | 32 | /note="Proton acceptor" | D | ||||||||
| ACT_SITE | 173 | 173 | /note="Proton donor" | D | ||||||||
| BINDING | 30 | 30 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
H | 1 | |||||||
| BINDING | 32 | 32 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
D | 1 | |||||||
| BINDING | 63 | 63 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
H | 1 | |||||||
| BINDING | 173 | 173 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
D | 1 | |||||||
| BINDING | 6 | 6 | /ligand="substrate" | S | ||||||||
| BINDING | 63 | 63 | /ligand="substrate" | H | ||||||||
Additional information
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| Size range | 210-260 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |