HAMAP rule MF_02229
General rule information
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Accession | MF_02229 |
Dates | 25-SEP-2019 (Created)
1-JUN-2023 (Last updated, Version 5) |
Name | Deoxyribose1P_isomerase |
Scope(s) |
Bacteria |
Template(s) | P0DTQ1 (DRDI_BACT7); [ Recover all ] |
Triggered by |
HAMAP; MF_02229 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | DRDI |
Protein name | RecName: Full=5-deoxyribose 1-phosphate isomerase; EC=5.3.1.-; |
Gene name | Name=drdI; |
Comments
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FUNCTION | Catalyzes the isomerization of 5-deoxy-alpha-D-ribose 1- phosphate to 5-deoxy-D-ribulose 1-phosphate, as part of a 5-deoxyribose salvage pathway that recycles this toxic radical SAM enzyme by-product to mainstream metabolites. |
CATALYTIC ACTIVITY | Reaction=5-deoxy-alpha-D-ribose 1-phosphate = 5-deoxy-D-ribulose 1- phosphate; Xref=Rhea:RHEA:61296, ChEBI:CHEBI:58749, ChEBI:CHEBI:144504; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61297; |
PATHWAY | Carbohydrate degradation. |
SIMILARITY | Belongs to the EIF-2B alpha/beta/delta subunits family. DrdI subfamily. |
Keywords
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Gene Ontology
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GO:0016861; Molecular function:intramolecular oxidoreductase activity, interconverting aldoses and ketoses |
GO:0019323; Biological process:pentose catabolic process |
Cross-references
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Features
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From: DRDI_BACT7 (P0DTQ1) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 49 | 51 | /ligand="substrate" | R-G-A | ||||||||
BINDING | 250 | 251 | /ligand="substrate" | N-K | ||||||||
ACT_SITE | 240 | 240 | /note="Proton donor" | D | ||||||||
BINDING | 92 | 92 | /ligand="substrate" | R | ||||||||
BINDING | 199 | 199 | /ligand="substrate" | Q | ||||||||
SITE | 160 | 160 | /note="Transition state stabilizer" | C |
Additional information
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Size range | 340-390 amino acids |
Related rules |
MF_01678 |
Fusion | Nter: None Cter: None |