HAMAP rule MF_02229

General rule information [?]

Accession	MF_02229
Dates	25-SEP-2019 (Created) 1-JUN-2023 (Last updated, Version 5)

Name	Deoxyribose1P_isomerase

Scope

Bacteria

Template

P0DTQ1 (DRDI_BACT7)

Triggered by

HAMAP; MF_02229 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

DRDI

Protein name

RecName:		Full=5-deoxyribose 1-phosphate isomerase;
		EC 5.3.1.-;

Gene name

drdI

Comments [?]

Function	Catalyzes the isomerization of 5-deoxy-alpha-D-ribose 1-phosphate to 5-deoxy-D-ribulose 1-phosphate, as part of a 5-deoxyribose salvage pathway that recycles this toxic radical SAM enzyme by-product to mainstream metabolites.
Catalytic activity	RHEA:61296: 5-deoxy-alpha-D-ribose 1-phosphate = 5-deoxy-D-ribulose 1-phosphate PhysiologicalDirection=left-to-right (RHEA:61297)
Pathway	Carbohydrate degradation.
Similarity	Belongs to the EIF-2B alpha/beta/delta subunits family. DrdI subfamily.

Keywords [?]

Carbohydrate metabolism
Isomerase

Gene Ontology [?]

GO:0016861; Molecular function: intramolecular oxidoreductase activity, interconverting aldoses and ketoses.
GO:0019323; Biological process: pentose catabolic process.

Cross-references [?]

Pfam	PF01008; IF-2B; 1;
NCBIfam	TIGR00524; eIF-2B_rel; 1;
	TIGR00512; salvage_mtnA; 1;

Features [?]

From: DRDI_BACT7 (P0DTQ1)

Key From To Description Tag Condition FTGroup

BINDING 49 51 /ligand="substrate R-G-A

BINDING 250 251 /ligand="substrate N-K

ACT_SITE 240 240 Proton donor D

BINDING 92 92 /ligand="substrate R

BINDING 199 199 /ligand="substrate Q

SITE 160 160 Transition state stabilizer C

Additional information [?]

Size range	340-390 amino acids
Related rules	MF_01678 (MTNA)
Fusion	None

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