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HAMAP rule MF_02229

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General rule information [?]

Accession MF_02229
Dates 25-SEP-2019 (Created)
1-JUN-2023 (Last updated, Version 5)
Name Deoxyribose1P_isomerase
Scope(s) Bacteria
Template(s) P0DTQ1 (DRDI_BACT7); [ Recover all ]
Triggered by HAMAP; MF_02229 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DRDI
Protein name RecName: Full=5-deoxyribose 1-phosphate isomerase;
Gene name Name=drdI;

Comments [?]

FUNCTIONCatalyzes the isomerization of 5-deoxy-alpha-D-ribose 1- phosphate to 5-deoxy-D-ribulose 1-phosphate, as part of a 5-deoxyribose salvage pathway that recycles this toxic radical SAM enzyme by-product to mainstream metabolites.
CATALYTIC ACTIVITY Reaction=5-deoxy-alpha-D-ribose 1-phosphate = 5-deoxy-D-ribulose 1- phosphate; Xref=Rhea:RHEA:61296, ChEBI:CHEBI:58749, ChEBI:CHEBI:144504; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61297;
PATHWAYCarbohydrate degradation.
SIMILARITYBelongs to the EIF-2B alpha/beta/delta subunits family. DrdI subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016861; Molecular function:intramolecular oxidoreductase activity, interconverting aldoses and ketoses
GO:0019323; Biological process:pentose catabolic process

Cross-references [?]

Pfam PF01008; IF-2B; 1;
NCBIfam TIGR00524; eIF-2B_rel; 1;
NCBIfam TIGR00512; salvage_mtnA; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 49 51 /ligand="substrate" R-G-A
BINDING 250 251 /ligand="substrate" N-K
ACT_SITE 240 240 /note="Proton donor" D
BINDING 92 92 /ligand="substrate" R
BINDING 199 199 /ligand="substrate" Q
SITE 160 160 /note="Transition state stabilizer" C

Additional information [?]

Size range 340-390 amino acids
Related rules MF_01678
Fusion Nter: None Cter: None

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