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Annotation rule MF_02235 |
Accession | MF_02235 |
Dates | 16-OCT-2019 (Created) 20-NOV-2019 (Last updated, Version 2) |
Name | SOTCase |
Scope | Bacteria |
Template | E1WKT5 (SOTC_BACF6) |
Triggered by |
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Protein name |
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Gene name |
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Function | Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-succinyl-L-ornithine to produce N(2)-succinyl-L-citrulline. Is essential for arginine biosynthesis. |
Catalytic activity | RHEA:25884: carbamoyl phosphate + N(2)-succinyl-L-ornithine = H(+) + N(2)-succinyl-L-citrulline + phosphate
EC 2.1.3.11 PhysiologicalDirection=left-to-right (RHEA:25885) |
Pathway | Amino-acid biosynthesis; L-arginine biosynthesis. |
Subunit | Homotrimer. |
Similarity | Belongs to the aspartate/ornithine carbamoyltransferase superfamily. SOTCase family. |
Pfam | PF00185; OTCace; 1; |
PF02729; OTCace_N; 1; | |
PRINTS | PR00100; AOTCASE; 1; |
PROSITE | PS00097; CARBAMOYLTRANSFERASE; 1; |
From: SOTC_BACF6 (E1WKT5) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 47 | 50 | Carbamoyl phosphate binding | S-[LM]-R-T | ||||||||
REGION | 147 | 150 | Carbamoyl phosphate binding | H-P-[LC]-Q | ||||||||
REGION | 274 | 275 | Carbamoyl phosphate binding | C-L | ||||||||
BINDING | 75 | 75 | Carbamoyl phosphate; shared with neighboring subunit | W | ||||||||
BINDING | 110 | 110 | Carbamoyl phosphate | R | ||||||||
BINDING | 142 | 142 | N(2)-succinyl-L-ornithine | E | ||||||||
BINDING | 176 | 176 | N(2)-succinyl-L-ornithine | H | ||||||||
BINDING | 236 | 236 | N(2)-succinyl-L-ornithine | K | ||||||||
BINDING | 278 | 278 | N(2)-succinyl-L-ornithine | R | ||||||||
BINDING | 302 | 302 | Carbamoyl phosphate | R |
Size range | 270-360 amino acids |
Related rules | None |
Fusion | None |