HAMAP rule MF_02235
General rule information
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| Accession | MF_02235 |
| Dates | 16-OCT-2019 (Created)
19-NOV-2022 (Last updated, Version 6) |
| Name | SOTCase |
| Scope(s) |
Bacteria |
| Template(s) | E1WKT5 (SOTC_BACF6); [ Recover all ] |
| Triggered by |
HAMAP; MF_02235 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | SOTC |
| Protein name | RecName: Full=N-succinylornithine carbamoyltransferase; EC=2.1.3.11; AltName: Full=N-succinyl-L-ornithine transcarbamylase; Short=SOTCase; |
| Gene name | Name=argF'; |
Comments
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| FUNCTION | Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-succinyl-L-ornithine to produce N(2)-succinyl-L-citrulline. Is essential for arginine biosynthesis. |
| CATALYTIC ACTIVITY | Reaction=carbamoyl phosphate + N(2)-succinyl-L-ornithine = H(+) + N(2)- succinyl-L-citrulline + phosphate; Xref=Rhea:RHEA:25884, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58228, ChEBI:CHEBI:58514, ChEBI:CHEBI:58862; EC=2.1.3.11; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25885; |
| PATHWAY | Amino-acid biosynthesis; L-arginine biosynthesis. |
| SUBUNIT | Homotrimer. |
| SIMILARITY | Belongs to the aspartate/ornithine carbamoyltransferase superfamily. SOTCase family. |
Keywords
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Gene Ontology
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| GO:0016743; Molecular function:carboxyl- or carbamoyltransferase activity |
| GO:0006526; Biological process:arginine biosynthetic process |
Cross-references
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| Pfam | PF00185; OTCace; 1; |
| Pfam | PF02729; OTCace_N; 1; |
| PRINTS | PR00100; AOTCASE; 1; |
| PROSITE | PS00097; CARBAMOYLTRANSFERASE; 1; |
Features
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| From: SOTC_BACF6 (E1WKT5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 47 | 50 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain" |
S-[LM]-R-T | ||||||||
| BINDING | 147 | 150 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain" |
H-P-[LC]-Q | ||||||||
| BINDING | 274 | 275 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain" |
C-L | ||||||||
| BINDING | 75 | 75 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" |
W | ||||||||
| BINDING | 110 | 110 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain" |
R | ||||||||
| BINDING | 142 | 142 | /ligand="N(2)-succinyl-L-ornithine" /ligand_id="ChEBI:CHEBI:58514" |
E | ||||||||
| BINDING | 176 | 176 | /ligand="N(2)-succinyl-L-ornithine" /ligand_id="ChEBI:CHEBI:58514" |
H | ||||||||
| BINDING | 236 | 236 | /ligand="N(2)-succinyl-L-ornithine" /ligand_id="ChEBI:CHEBI:58514" |
K | ||||||||
| BINDING | 278 | 278 | /ligand="N(2)-succinyl-L-ornithine" /ligand_id="ChEBI:CHEBI:58514" |
R | ||||||||
| BINDING | 302 | 302 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain" |
R | ||||||||
Additional information
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| Size range | 270-360 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |