HAMAP rule MF_02235
General rule information
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Accession | MF_02235 |
Dates | 16-OCT-2019 (Created) 19-NOV-2022 (Last updated, Version 6) |
Name | SOTCase |
Scope | Bacteria |
Template | E1WKT5 (SOTC_BACF6) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-succinyl-L-ornithine to produce N(2)-succinyl-L-citrulline. Is essential for arginine biosynthesis. |
Catalytic activity | RHEA:25884: carbamoyl phosphate + N(2)-succinyl-L-ornithine = H(+) + N(2)-succinyl-L-citrulline + phosphate
EC 2.1.3.11 PhysiologicalDirection=left-to-right (RHEA:25885) |
Pathway | Amino-acid biosynthesis; L-arginine biosynthesis. |
Subunit | Homotrimer. |
Similarity | Belongs to the aspartate/ornithine carbamoyltransferase superfamily. SOTCase family. |
Keywords
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Gene Ontology
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GO:0016743; Molecular function: carboxyl- or carbamoyltransferase activity.
GO:0006526; Biological process: arginine biosynthetic process.
GO:0006526; Biological process: arginine biosynthetic process.
Cross-references
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Pfam | PF00185; OTCace; 1; |
PF02729; OTCace_N; 1; | |
PRINTS | PR00100; AOTCASE; 1; |
PROSITE | PS00097; CARBAMOYLTRANSFERASE; 1; |
Features
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From: SOTC_BACF6 (E1WKT5) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 47 | 50 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain | S-[LM]-R-T | ||||||||
BINDING | 147 | 150 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain | H-P-[LC]-Q | ||||||||
BINDING | 274 | 275 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain | C-L | ||||||||
BINDING | 75 | 75 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits | W | ||||||||
BINDING | 110 | 110 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain | R | ||||||||
BINDING | 142 | 142 | /ligand="N(2)-succinyl-L-ornithine" /ligand_id="ChEBI:CHEBI:58514 | E | ||||||||
BINDING | 176 | 176 | /ligand="N(2)-succinyl-L-ornithine" /ligand_id="ChEBI:CHEBI:58514 | H | ||||||||
BINDING | 236 | 236 | /ligand="N(2)-succinyl-L-ornithine" /ligand_id="ChEBI:CHEBI:58514 | K | ||||||||
BINDING | 278 | 278 | /ligand="N(2)-succinyl-L-ornithine" /ligand_id="ChEBI:CHEBI:58514 | R | ||||||||
BINDING | 302 | 302 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain | R |
Additional information
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Size range | 270-360 amino acids |
Related rules | None |
Fusion | None |