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Annotation rule MF_02235
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General rule information [?]

Accession MF_02235
Dates 16-OCT-2019 (Created)
20-NOV-2019 (Last updated, Version 2)
Name SOTCase
Scope
Bacteria
Template E1WKT5 (SOTC_BACF6)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SOTC
Protein name
RecName: Full=N-succinylornithine carbamoyltransferase;
EC 2.1.3.11;
AltName: Full=N-succinyl-L-ornithine transcarbamylase;
Short=SOTCase;
Gene name
argF'

Comments [?]

Function Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-succinyl-L-ornithine to produce N(2)-succinyl-L-citrulline. Is essential for arginine biosynthesis.
Catalytic activity RHEA:25884: carbamoyl phosphate + N(2)-succinyl-L-ornithine = H(+) + N(2)-succinyl-L-citrulline + phosphate
EC 2.1.3.11
PhysiologicalDirection=left-to-right (RHEA:25885)
Pathway Amino-acid biosynthesis; L-arginine biosynthesis.
Subunit Homotrimer.
Similarity Belongs to the aspartate/ornithine carbamoyltransferase superfamily. SOTCase family.

Keywords [?]

Amino-acid biosynthesis
Arginine biosynthesis
Transferase

Gene Ontology [?]

GO:0016743; Molecular function: carboxyl- or carbamoyltransferase activity.
GO:0006526; Biological process: arginine biosynthetic process.

Cross-references [?]

Pfam PF00185; OTCace; 1;
PF02729; OTCace_N; 1;
PRINTS PR00100; AOTCASE; 1;
PROSITE PS00097; CARBAMOYLTRANSFERASE; 1;

Features [?]

From: SOTC_BACF6 (E1WKT5)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     47     50       Carbamoyl phosphate binding     S-[LM]-R-T  
REGION     147     150       Carbamoyl phosphate binding     H-P-[LC]-Q  
REGION     274     275       Carbamoyl phosphate binding     C-L  
BINDING     75     75       Carbamoyl phosphate; shared with neighboring subunit     W  
BINDING     110     110       Carbamoyl phosphate     R  
BINDING     142     142       N(2)-succinyl-L-ornithine     E  
BINDING     176     176       N(2)-succinyl-L-ornithine     H  
BINDING     236     236       N(2)-succinyl-L-ornithine     K  
BINDING     278     278       N(2)-succinyl-L-ornithine     R  
BINDING     302     302       Carbamoyl phosphate     R  

Additional information [?]

Size range 270-360 amino acids
Related rules None
Fusion None


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