HAMAP rule MF_02235

General rule information [?]

Accession	MF_02235
Dates	16-OCT-2019 (Created) 19-NOV-2022 (Last updated, Version 6)

Name

SOTCase

Scope

Bacteria

Template

E1WKT5 (SOTC_BACF6)

Triggered by

HAMAP; MF_02235 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

SOTC

Protein name

RecName:		Full=N-succinylornithine carbamoyltransferase;
		EC 2.1.3.11;
AltName:		Full=N-succinyl-L-ornithine transcarbamylase;
		Short=SOTCase;

Gene name

argF'

Comments [?]

Function	Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-succinyl-L-ornithine to produce N(2)-succinyl-L-citrulline. Is essential for arginine biosynthesis.
Catalytic activity	RHEA:25884: carbamoyl phosphate + N(2)-succinyl-L-ornithine = H(+) + N(2)-succinyl-L-citrulline + phosphate EC 2.1.3.11 PhysiologicalDirection=left-to-right (RHEA:25885)
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis.
Subunit	Homotrimer.
Similarity	Belongs to the aspartate/ornithine carbamoyltransferase superfamily. SOTCase family.

Keywords [?]

Amino-acid biosynthesis
Arginine biosynthesis
Transferase

Gene Ontology [?]

GO:0016743; Molecular function: carboxyl- or carbamoyltransferase activity.
GO:0006526; Biological process: arginine biosynthetic process.

Cross-references [?]

Pfam	PF00185; OTCace; 1;
	PF02729; OTCace_N; 1;
PRINTS	PR00100; AOTCASE; 1;
PROSITE	PS00097; CARBAMOYLTRANSFERASE; 1;

Features [?]

From: SOTC_BACF6 (E1WKT5)

Key From To Description Tag Condition FTGroup

BINDING 47 50 /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain S-[LM]-R-T

BINDING 147 150 /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain H-P-[LC]-Q

BINDING 274 275 /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain C-L

BINDING 75 75 /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits W

BINDING 110 110 /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain R

BINDING 142 142 /ligand="N(2)-succinyl-L-ornithine" /ligand_id="ChEBI:CHEBI:58514 E

BINDING 176 176 /ligand="N(2)-succinyl-L-ornithine" /ligand_id="ChEBI:CHEBI:58514 H

BINDING 236 236 /ligand="N(2)-succinyl-L-ornithine" /ligand_id="ChEBI:CHEBI:58514 K

BINDING 278 278 /ligand="N(2)-succinyl-L-ornithine" /ligand_id="ChEBI:CHEBI:58514 R

BINDING 302 302 /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain R

Additional information [?]

Size range	270-360 amino acids
Related rules	None
Fusion	None

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