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HAMAP rule MF_02235

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General rule information [?]

Accession MF_02235
Dates 16-OCT-2019 (Created)
19-NOV-2022 (Last updated, Version 6)
Name SOTCase
Scope(s) Bacteria
Template(s) E1WKT5 (SOTC_BACF6); [ Recover all ]
Triggered by HAMAP; MF_02235 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SOTC
Protein name RecName: Full=N-succinylornithine carbamoyltransferase;
                 EC=2.1.3.11;
AltName: Full=N-succinyl-L-ornithine transcarbamylase;
                 Short=SOTCase;
Gene name Name=argF';

Comments [?]

FUNCTIONCatalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-succinyl-L-ornithine to produce N(2)-succinyl-L-citrulline. Is essential for arginine biosynthesis.
CATALYTIC ACTIVITY Reaction=carbamoyl phosphate + N(2)-succinyl-L-ornithine = H(+) + N(2)- succinyl-L-citrulline + phosphate; Xref=Rhea:RHEA:25884, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58228, ChEBI:CHEBI:58514, ChEBI:CHEBI:58862; EC=2.1.3.11; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25885;
PATHWAYAmino-acid biosynthesis; L-arginine biosynthesis.
SUBUNITHomotrimer.
SIMILARITYBelongs to the aspartate/ornithine carbamoyltransferase superfamily. SOTCase family.

Keywords [?]


Gene Ontology [?]

GO:0016743; Molecular function:carboxyl- or carbamoyltransferase activity
GO:0006526; Biological process:arginine biosynthetic process

Cross-references [?]

Pfam PF00185; OTCace; 1;
Pfam PF02729; OTCace_N; 1;
PRINTS PR00100; AOTCASE; 1;
PROSITE PS00097; CARBAMOYLTRANSFERASE; 1;

Features [?]

From: SOTC_BACF6 (E1WKT5)
Key From To Description Tag Condition FTGroup
BINDING 47 50 /ligand="carbamoyl phosphate"
/ligand_id="ChEBI:CHEBI:58228"
/ligand_note="ligand shared between two neighboring subunits"
/note="in other chain"
S-[LM]-R-T
BINDING 147 150 /ligand="carbamoyl phosphate"
/ligand_id="ChEBI:CHEBI:58228"
/ligand_note="ligand shared between two neighboring subunits"
/note="in other chain"
H-P-[LC]-Q
BINDING 274 275 /ligand="carbamoyl phosphate"
/ligand_id="ChEBI:CHEBI:58228"
/ligand_note="ligand shared between two neighboring subunits"
/note="in other chain"
C-L
BINDING 75 75 /ligand="carbamoyl phosphate"
/ligand_id="ChEBI:CHEBI:58228"
/ligand_note="ligand shared between two neighboring subunits"
W
BINDING 110 110 /ligand="carbamoyl phosphate"
/ligand_id="ChEBI:CHEBI:58228"
/ligand_note="ligand shared between two neighboring subunits"
/note="in other chain"
R
BINDING 142 142 /ligand="N(2)-succinyl-L-ornithine"
/ligand_id="ChEBI:CHEBI:58514"
E
BINDING 176 176 /ligand="N(2)-succinyl-L-ornithine"
/ligand_id="ChEBI:CHEBI:58514"
H
BINDING 236 236 /ligand="N(2)-succinyl-L-ornithine"
/ligand_id="ChEBI:CHEBI:58514"
K
BINDING 278 278 /ligand="N(2)-succinyl-L-ornithine"
/ligand_id="ChEBI:CHEBI:58514"
R
BINDING 302 302 /ligand="carbamoyl phosphate"
/ligand_id="ChEBI:CHEBI:58228"
/ligand_note="ligand shared between two neighboring subunits"
/note="in other chain"
R

Additional information [?]

Size range 270-360 amino acids
Related rules None
Fusion Nter: None Cter: None



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