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HAMAP rule MF_02236

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General rule information [?]

Accession MF_02236
Dates 16-OCT-2019 (Created)
19-NOV-2022 (Last updated, Version 4)
Name ACDase
Scope(s) Bacteria
Template(s) Q8P8J5 (ACDAS_XANCP); [ Recover all ]
Triggered by HAMAP; MF_02236 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ACDAS
Protein name RecName: Full=N-acetyl-L-citrulline deacetylase;
                 Short=Acetylcitrulline deacetylase;
Gene name Name=argE';

Comments [?]

FUNCTIONCatalyzes the deacetylation of N-acetyl-L-citrulline to produce L-citrulline. This is a step in an alternative arginine biosynthesis pathway.
CATALYTIC ACTIVITY Reaction=H2O + N(2)-acetyl-L-citrulline = acetate + L-citrulline; Xref=Rhea:RHEA:61092, ChEBI:CHEBI:15377, ChEBI:CHEBI:30089, ChEBI:CHEBI:57743, ChEBI:CHEBI:58765; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61093;
COFACTOR Name=Co(2+); Xref=ChEBI:CHEBI:48828; Note=Binds 1 Co(2+) ion per subunit.;
PATHWAYAmino-acid biosynthesis; L-arginine biosynthesis.
SIMILARITYBelongs to the peptidase M20A family. N-acetylcitrulline deacetylase subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016811; Molecular function:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0050897; Molecular function:cobalt ion binding
GO:0006526; Biological process:arginine biosynthetic process

Cross-references [?]

Pfam PF07687; M20_dimer; 1;
Pfam PF01546; Peptidase_M20; 1;

Features [?]

Key From To Description Tag Condition FTGroup
ACT_SITE 130 130 /note="Proton donor/acceptor" E
BINDING 72 72 /ligand="Co(2+)"
BINDING 103 103 /ligand="Co(2+)"
BINDING 155 155 /ligand="Co(2+)"

Additional information [?]

Size range 335-420 amino acids
Related rules None
Fusion Nter: None Cter: None

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