HAMAP logo

HAMAP rule MF_02236

Send feedback

General rule information [?]

Accession MF_02236
Dates 16-OCT-2019 (Created)
19-NOV-2022 (Last updated, Version 4)
Name ACDase
Template Q8P8J5 (ACDAS_XANCP)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=N-acetyl-L-citrulline deacetylase;
Short=Acetylcitrulline deacetylase;
EC 3.5.1.-;
Gene name

Comments [?]

Function Catalyzes the deacetylation of N-acetyl-L-citrulline to produce L-citrulline. This is a step in an alternative arginine biosynthesis pathway.
Catalytic activity RHEA:61092: H2O + N(2)-acetyl-L-citrulline = acetate + L-citrulline
PhysiologicalDirection=left-to-right (RHEA:61093)
Cofactor Co(2+)
Note: Binds 1 Co(2+) ion per subunit.
Pathway Amino-acid biosynthesis; L-arginine biosynthesis.
Similarity Belongs to the peptidase M20A family. N-acetylcitrulline deacetylase subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016811; Molecular function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides.
GO:0050897; Molecular function: cobalt ion binding.
GO:0006526; Biological process: arginine biosynthetic process.

Cross-references [?]

Pfam PF07687; M20_dimer; 1;
PF01546; Peptidase_M20; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     130     130       Proton donor/acceptor     E  
BINDING     72     72       /ligand="Co(2+)" /ligand_id="ChEBI:CHEBI:48828     H  
BINDING     103     103       /ligand="Co(2+)" /ligand_id="ChEBI:CHEBI:48828     D  
BINDING     155     155       /ligand="Co(2+)" /ligand_id="ChEBI:CHEBI:48828     E  

Additional information [?]

Size range 335-420 amino acids
Related rules None
Fusion None