HAMAP rule MF_02236

General rule information [?]

Accession	MF_02236
Dates	16-OCT-2019 (Created) 19-NOV-2022 (Last updated, Version 4)

Name

ACDase

Scope

Bacteria

Template

Q8P8J5 (ACDAS_XANCP)

Triggered by

HAMAP; MF_02236 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

ACDAS

Protein name

RecName:		Full=N-acetyl-L-citrulline deacetylase;
		Short=ACDase;
		Short=Acetylcitrulline deacetylase;
		EC 3.5.1.-;

Gene name

argE'

Comments [?]

Function	Catalyzes the deacetylation of N-acetyl-L-citrulline to produce L-citrulline. This is a step in an alternative arginine biosynthesis pathway.
Catalytic activity	RHEA:61092: H2O + N(2)-acetyl-L-citrulline = acetate + L-citrulline PhysiologicalDirection=left-to-right (RHEA:61093)
Cofactor	Co(2+) Note: Binds 1 Co(2+) ion per subunit.
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis.
Similarity	Belongs to the peptidase M20A family. N-acetylcitrulline deacetylase subfamily.

Keywords [?]

Amino-acid biosynthesis
Arginine biosynthesis
Cobalt
Hydrolase
Metal-binding

Gene Ontology [?]

GO:0016811; Molecular function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides.
GO:0050897; Molecular function: cobalt ion binding.
GO:0006526; Biological process: arginine biosynthetic process.

Cross-references [?]

Pfam	PF07687; M20_dimer; 1;
	PF01546; Peptidase_M20; 1;

Features [?]

From: ACDAS_XANCP (Q8P8J5)

Key From To Description Tag Condition FTGroup

ACT_SITE 130 130 Proton donor/acceptor E

BINDING 72 72 /ligand="Co(2+)" /ligand_id="ChEBI:CHEBI:48828 H

BINDING 103 103 /ligand="Co(2+)" /ligand_id="ChEBI:CHEBI:48828 D

BINDING 155 155 /ligand="Co(2+)" /ligand_id="ChEBI:CHEBI:48828 E

Additional information [?]

Size range	335-420 amino acids
Related rules	None
Fusion	None

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