HAMAP rule MF_02237

General rule information [?]

Accession	MF_02237
Dates	28-NOV-2019 (Created) 19-NOV-2022 (Last updated, Version 4)

Name

NSUN6

Scope

Archaea

Template

O57712 (NSUN6_PYRHO)

Triggered by

HAMAP; MF_02237 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

NSUN6

Protein name

RecName:		Full=tRNA (cytosine(72)-C(5))-methyltransferase;
		Short=tRNA:m(5)C72 MTase;
		EC 2.1.1.-;

Comments [?]

Function	S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.
Catalytic activity	RHEA:61988: cytidine(72) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine PhysiologicalDirection=left-to-right (RHEA:61989)
Similarity	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

Keywords [?]

Methyltransferase
RNA-binding
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0016428; Molecular function: tRNA (cytosine-5-)-methyltransferase activity.
GO:0000049; Molecular function: tRNA binding.
GO:0006400; Biological process: tRNA modification.

Cross-references [?]

PROSITE	PS50890; PUA; 0-1; trigger=PRU00161;
	PS51686; SAM_MT_RSMB_NOP; 1;
Pfam	PF01189; Methyltr_RsmB-F; 1;
	PF01472; PUA; 0-1;
	PF17125; Methyltr_RsmF_N; 0-1;
TIGRFAMs	TIGR00446; nop2p; 0-1;
	TIGR00451; unchar_dom_2; 0-1;

Features [?]

From: NSUN6_PYRHO (O57712)

Key From To Description Tag Condition FTGroup

BINDING (Optional) 209 215 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 [ACSV]-[ACPS]-[AGP]-[PQ]-[AG]-[GINS]-K

ACT_SITE 327 327 Nucleophile C

BINDING (Optional) 233 233 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 [DE]

BINDING (Optional) 238 238 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 [RK]

BINDING (Optional) 260 260 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 D

BINDING (Optional) 277 277 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 D

BINDING (Optional) 304 304 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 Y

Additional information [?]

Size range	320-420 amino acids
Related rules	None
Fusion	None

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