HAMAP rule MF_02237
General rule information
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| Accession | MF_02237 |
| Dates | 28-NOV-2019 (Created)
13-OCT-2023 (Last updated, Version 6) |
| Name | NSUN6 |
| Scope(s) |
Archaea |
| Template(s) | O57712 (NSUN6_PYRHO); [ Recover all ] |
| Triggered by |
HAMAP; MF_02237 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | NSUN6 |
| Protein name | RecName: Full=tRNA (cytosine(72)-C(5))-methyltransferase; Short=tRNA:m(5)C72 MTase; EC=2.1.1.-; |
Comments
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| FUNCTION | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs. |
| CATALYTIC ACTIVITY | Reaction=cytidine(72) in tRNA + S-adenosyl-L-methionine = 5- methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:61988, Rhea:RHEA-COMP:15996, Rhea:RHEA-COMP:15997, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74483, ChEBI:CHEBI:82748; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61989; |
| SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. |
Keywords
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Gene Ontology
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| GO:0016428; Molecular function:tRNA (cytidine-5-)-methyltransferase activity |
| GO:0000049; Molecular function:tRNA binding |
| GO:0006400; Biological process:tRNA modification |
Cross-references
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| PROSITE | PS50890; PUA; 0-1; |
| PROSITE | PS51686; SAM_MT_RSMB_NOP; 1; |
| Pfam | PF01189; Methyltr_RsmB-F; 1; |
| Pfam | PF01472; PUA; 0-1; |
| Pfam | PF17125; Methyltr_RsmF_N; 0-1; |
| NCBIfam | TIGR00446; nop2p; 0-1; |
| NCBIfam | TIGR00451; unchar_dom_2; 0-1; |
Features
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| From: NSUN6_PYRHO (O57712) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 209 | 215 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[ACSV]-[ACPS]-[AGP]-[PQ]-[AG]-[GINS]-K | ||||||||
| ACT_SITE | 327 | 327 | /note="Nucleophile" | C | ||||||||
| BINDING | 233 | 233 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[DE] | ||||||||
| BINDING | 238 | 238 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[RK] | ||||||||
| BINDING | 260 | 260 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D | ||||||||
| BINDING | 277 | 277 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D | ||||||||
| BINDING | 304 | 304 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
Y | ||||||||
Additional information
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| Size range | 320-420 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |