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HAMAP rule MF_02237

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General rule information [?]

Accession MF_02237
Dates 28-NOV-2019 (Created)
13-OCT-2023 (Last updated, Version 6)
Name NSUN6
Scope(s) Archaea
Template(s) O57712 (NSUN6_PYRHO); [ Recover all ]
Triggered by HAMAP; MF_02237 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NSUN6
Protein name RecName: Full=tRNA (cytosine(72)-C(5))-methyltransferase;
                 Short=tRNA:m(5)C72 MTase;

Comments [?]

FUNCTIONS-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.
CATALYTIC ACTIVITY Reaction=cytidine(72) in tRNA + S-adenosyl-L-methionine = 5- methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:61988, Rhea:RHEA-COMP:15996, Rhea:RHEA-COMP:15997, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74483, ChEBI:CHEBI:82748; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61989;
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

Keywords [?]

Gene Ontology [?]

GO:0016428; Molecular function:tRNA (cytidine-5-)-methyltransferase activity
GO:0000049; Molecular function:tRNA binding
GO:0006400; Biological process:tRNA modification

Cross-references [?]

PROSITE PS50890; PUA; 0-1;
Pfam PF01189; Methyltr_RsmB-F; 1;
Pfam PF01472; PUA; 0-1;
Pfam PF17125; Methyltr_RsmF_N; 0-1;
NCBIfam TIGR00446; nop2p; 0-1;
NCBIfam TIGR00451; unchar_dom_2; 0-1;

Features [?]

From: NSUN6_PYRHO (O57712)
Key From To Description Tag Condition FTGroup
BINDING 209 215 /ligand="S-adenosyl-L-methionine"
ACT_SITE 327 327 /note="Nucleophile" C
BINDING 233 233 /ligand="S-adenosyl-L-methionine"
BINDING 238 238 /ligand="S-adenosyl-L-methionine"
BINDING 260 260 /ligand="S-adenosyl-L-methionine"
BINDING 277 277 /ligand="S-adenosyl-L-methionine"
BINDING 304 304 /ligand="S-adenosyl-L-methionine"

Additional information [?]

Size range 320-420 amino acids
Related rules None
Fusion Nter: None Cter: None

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