HAMAP rule MF_02238
General rule information
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Accession | MF_02238 |
Dates | 3-DEC-2019 (Created)
7-MAY-2024 (Last updated, Version 4) |
Name | DSD |
Scope(s) |
Bacteria |
Template(s) | Q88JU3 (DSD_PSEPK); Q9I6P6 (DSD_PSEAE); [ Recover all ] |
Triggered by |
HAMAP; MF_02238 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | DSD |
Protein name | RecName: Full=3-dehydroshikimate dehydratase; Short=DSD; EC=4.2.1.118; |
Comments
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FUNCTION | Catalyzes the conversion of 3-dehydroshikimate to protocatechuate (3,4-dihydroxybenzoate), a common intermediate of quinate and shikimate degradation pathways. |
CATALYTIC ACTIVITY | Reaction=3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O; Xref=Rhea:RHEA:24848, ChEBI:CHEBI:15377, ChEBI:CHEBI:16630, ChEBI:CHEBI:36241; EC=4.2.1.118; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24849; |
COFACTOR | Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; |
PATHWAY | Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis. |
SIMILARITY | Belongs to the bacterial two-domain DSD family. |
Keywords
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Gene Ontology
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GO:0046565; Molecular function:3-dehydroshikimate dehydratase activity |
GO:0046872; Molecular function:metal ion binding |
GO:0046279; Biological process:3,4-dihydroxybenzoate biosynthetic process |
Cross-references
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Features
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From: DSD_PSEPK (Q88JU3) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 134 | 134 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_note="catalytic" |
E | 1 | |||||||
BINDING | 165 | 165 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_note="catalytic" |
D | 1 | |||||||
BINDING | 191 | 191 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_note="catalytic" |
Q | 1 | |||||||
BINDING | 239 | 239 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_note="catalytic" |
E | 1 | |||||||
BINDING | 443 | 443 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
H | 2 | |||||||
BINDING | 521 | 521 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
H | 2 | |||||||
BINDING | 599 | 599 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | 2 |
Additional information
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Size range | 570-690 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |