HAMAP rule MF_02238

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_02238
Accession	MF_02238
Dates	03-DEC-2019 (Created) 07-MAY-2024 (Last updated, Version 5)
Name	DSD
Scope(s)	Bacteria
Template(s)	Q88JU3; Q9I6P6; [ Recover all ]
Triggered by	HAMAP; MF_02238 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	DSD
Protein name	RecName: Full=3-dehydroshikimate dehydratase; Short=DSD; EC=4.2.1.118;

Comments [?]

FUNCTION	Catalyzes the conversion of 3-dehydroshikimate to protocatechuate (3,4-dihydroxybenzoate), a common intermediate of quinate and shikimate degradation pathways.
CATALYTIC ACTIVITY	Reaction=3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O; Xref=Rhea:RHEA:24848, ChEBI:CHEBI:15377, ChEBI:CHEBI:16630, ChEBI:CHEBI:36241; EC=4.2.1.118; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24849;
COFACTOR	Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
PATHWAY	Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis.
SIMILARITY	Belongs to the bacterial two-domain DSD family.

Keywords [?]

Gene Ontology [?]

GO:0046565; Molecular function:3-dehydroshikimate dehydratase activity

GO:0046872; Molecular function:metal ion binding

GO:0046279; Biological process:3,4-dihydroxybenzoate biosynthetic process

Cross-references [?]

Features [?]

From: DSD_PSEPK (Q88JU3)
Key	From	To	Description	Tag	Condition	FTGroup
BINDING	134	134	/ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_note="catalytic"		E	1
BINDING	165	165	/ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_note="catalytic"		D	1
BINDING	191	191	/ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_note="catalytic"		Q	1
BINDING	239	239	/ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_note="catalytic"		E	1
BINDING	443	443	/ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420"		H	2
BINDING	521	521	/ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420"		H	2
BINDING	599	599	/ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420"		E	2

Additional information [?]