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HAMAP rule MF_02238

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General rule information [?]

Accession MF_02238
Dates 3-DEC-2019 (Created)
19-NOV-2022 (Last updated, Version 3)
Name DSD
Templates Q88JU3 (DSD_PSEPK); Q9I6P6 (DSD_PSEAE): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=3-dehydroshikimate dehydratase;

Comments [?]

Function Catalyzes the conversion of 3-dehydroshikimate to protocatechuate (3,4-dihydroxybenzoate), a common intermediate of quinate and shikimate degradation pathways.
Catalytic activity RHEA:24848: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O
PhysiologicalDirection=left-to-right (RHEA:24849)
Cofactor a divalent metal cation
Pathway Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis.
Similarity Belongs to the bacterial two-domain DSD family.

Keywords [?]

Gene Ontology [?]

GO:0046565; Molecular function: 3-dehydroshikimate dehydratase activity.
GO:0046872; Molecular function: metal ion binding.

Cross-references [?]

PROSITE PS51819; VOC; 2; trigger=PRU01163;
Pfam PF00903; Glyoxalase; 1;
PF01261; AP_endonuc_2; 1;

Features [?]

From: DSD_PSEPK (Q88JU3)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     134     134       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_note="catalytic     E   1
BINDING     165     165       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_note="catalytic     D   1
BINDING     191     191       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_note="catalytic     Q   1
BINDING     239     239       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_note="catalytic     E   1
BINDING (Optional)     443     443       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     H   2
BINDING (Optional)     521     521       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     H   2
BINDING (Optional)     599     599       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     E   2

Additional information [?]

Size range 570-690 amino acids
Related rules None
Fusion None