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HAMAP rule MF_02238

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General rule information [?]

Accession MF_02238
Dates 3-DEC-2019 (Created)
19-NOV-2022 (Last updated, Version 3)
Name DSD
Scope(s) Bacteria
Template(s) Q88JU3 (DSD_PSEPK); Q9I6P6 (DSD_PSEAE); [ Recover all ]
Triggered by HAMAP; MF_02238 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DSD
Protein name RecName: Full=3-dehydroshikimate dehydratase;
                 Short=DSD;
                 EC=4.2.1.118;

Comments [?]

FUNCTIONCatalyzes the conversion of 3-dehydroshikimate to protocatechuate (3,4-dihydroxybenzoate), a common intermediate of quinate and shikimate degradation pathways.
CATALYTIC ACTIVITY Reaction=3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O; Xref=Rhea:RHEA:24848, ChEBI:CHEBI:15377, ChEBI:CHEBI:16630, ChEBI:CHEBI:36241; EC=4.2.1.118; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24849;
COFACTOR Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
PATHWAYAromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis.
SIMILARITYBelongs to the bacterial two-domain DSD family.

Keywords [?]


Gene Ontology [?]

GO:0046565; Molecular function:3-dehydroshikimate dehydratase activity
GO:0046872; Molecular function:metal ion binding

Cross-references [?]

PROSITE PS51819; VOC; 2;
Pfam PF00903; Glyoxalase; 1;
Pfam PF01261; AP_endonuc_2; 1;

Features [?]

From: DSD_PSEPK (Q88JU3)
Key From To Description Tag Condition FTGroup
BINDING 134 134 /ligand="a divalent metal cation"
/ligand_id="ChEBI:CHEBI:60240"
/ligand_note="catalytic"
E 1
BINDING 165 165 /ligand="a divalent metal cation"
/ligand_id="ChEBI:CHEBI:60240"
/ligand_note="catalytic"
D 1
BINDING 191 191 /ligand="a divalent metal cation"
/ligand_id="ChEBI:CHEBI:60240"
/ligand_note="catalytic"
Q 1
BINDING 239 239 /ligand="a divalent metal cation"
/ligand_id="ChEBI:CHEBI:60240"
/ligand_note="catalytic"
E 1
BINDING 443 443 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
H 2
BINDING 521 521 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
H 2
BINDING 599 599 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
E 2

Additional information [?]

Size range 570-690 amino acids
Related rules None
Fusion Nter: None Cter: None



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