HAMAP rule MF_02239
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_02239 |
| Accession | MF_02239 |
| Dates | 12-DEC-2019 (Created)
02-SEP-2024 (Last updated, Version 8) |
| Name | HemJ |
| Scope(s) |
Bacteria |
| Template(s) | P72793; [ Recover all ] |
| Triggered by |
HAMAP; MF_02239 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | HEMJ |
| Protein name | RecName: Full=Protoporphyrinogen IX oxidase; Short=PPO; EC=1.3.99.-; |
Comments
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| FUNCTION | Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX. |
| CATALYTIC ACTIVITY | Reaction=protoporphyrinogen IX + 3 A = protoporphyrin IX + 3 AH2; Xref=Rhea:RHEA:62000, ChEBI:CHEBI:13193, ChEBI:CHEBI:17499, ChEBI:CHEBI:57306, ChEBI:CHEBI:57307; |
| COFACTOR | Name=heme b; Xref=ChEBI:CHEBI:60344; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.; |
| PATHWAY | Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1. |
| SUBUNIT | Homodimer. |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the HemJ family. |
Keywords
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Gene Ontology
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| GO:0070818; Molecular function:protoporphyrinogen oxidase activity |
| GO:0006782; Biological process:protoporphyrinogen IX biosynthetic process |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF03653; UPF0093; 1; |
| PIRSF | PIRSF004638; UCP004638; 0-1; |
| NCBIfam | TIGR00701; TIGR00701; 1; |
| General | Transmembrane; -; 4-5; |
Features
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| From: HEMJ_SYNY3 (P72793) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 27 | 27 | /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue" |
H | ||||||||
| BINDING | 108 | 108 | /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue" |
K | ||||||||
Additional information
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| Size range | 145-210 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |