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HAMAP rule MF_02239

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General rule information [?]

Accession MF_02239
Dates 12-DEC-2019 (Created)
1-JUN-2023 (Last updated, Version 5)
Name HemJ
Template P72793 (HEMJ_SYNY3)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Protoporphyrinogen IX oxidase;
EC 1.3.99.-;

Comments [?]

Function Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
Catalytic activity RHEA:62000: 3 A + protoporphyrinogen IX = 3 AH2 + protoporphyrin IX
Cofactor heme b
Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
Pathway Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.
Subunit Homodimer.
Subcellular location Cell membrane; Multi-pass membrane protein.
Similarity Belongs to the HemJ family.

Keywords [?]

Gene Ontology [?]

GO:0070818; Molecular function: protoporphyrinogen oxidase activity.
GO:0006779; Biological process: porphyrin-containing compound biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF03653; UPF0093; 1;
PIRSF PIRSF004638; UCP004638; 0-1;
NCBIfam TIGR00701; TIGR00701; 1;

Computed features [?]

General Transmembrane; -; 4-5; trigger=yes;

Features [?]

From: HEMJ_SYNY3 (P72793)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     27     27       /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H  
BINDING     108     108       /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     K  

Additional information [?]

Size range 145-210 amino acids
Related rules None
Fusion None