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HAMAP rule MF_02239

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General rule information [?]

Accession MF_02239
Dates 12-DEC-2019 (Created)
15-FEB-2024 (Last updated, Version 6)
Name HemJ
Scope(s) Bacteria
Template(s) P72793 (HEMJ_SYNY3); [ Recover all ]
Triggered by HAMAP; MF_02239 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HEMJ
Protein name RecName: Full=Protoporphyrinogen IX oxidase;
                 Short=PPO;
                 EC=1.3.99.-;

Comments [?]

FUNCTIONCatalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
CATALYTIC ACTIVITY Reaction=3 A + protoporphyrinogen IX = 3 AH2 + protoporphyrin IX; Xref=Rhea:RHEA:62000, ChEBI:CHEBI:13193, ChEBI:CHEBI:17499, ChEBI:CHEBI:57306, ChEBI:CHEBI:57307;
COFACTOR Name=heme b; Xref=ChEBI:CHEBI:60344; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.;
PATHWAYPorphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.
SUBUNITHomodimer.
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
SIMILARITYBelongs to the HemJ family.

Keywords [?]


Gene Ontology [?]

GO:0070818; Molecular function:protoporphyrinogen oxidase activity
GO:0006782; Biological process:protoporphyrinogen IX biosynthetic process
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF03653; UPF0093; 1;
PIRSF PIRSF004638; UCP004638; 0-1;
NCBIfam TIGR00701; TIGR00701; 1;
General Transmembrane; -; 4-5;

Features [?]

From: HEMJ_SYNY3 (P72793)
Key From To Description Tag Condition FTGroup
BINDING 27 27 /ligand="heme"
/ligand_id="ChEBI:CHEBI:30413"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"
H
BINDING 108 108 /ligand="heme"
/ligand_id="ChEBI:CHEBI:30413"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"
K

Additional information [?]

Size range 145-210 amino acids
Related rules None
Fusion Nter: None Cter: None



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