HAMAP rule MF_02239

General rule information [?]

Accession	MF_02239
Dates	12-DEC-2019 (Created) 1-JUN-2023 (Last updated, Version 5)

Name

HemJ

Scope

Bacteria

Template

P72793 (HEMJ_SYNY3)

Triggered by

HAMAP; MF_02239 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

HEMJ

Protein name

RecName:		Full=Protoporphyrinogen IX oxidase;
		Short=PPO;
		EC 1.3.99.-;

Comments [?]

Function	Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
Catalytic activity	RHEA:62000: 3 A + protoporphyrinogen IX = 3 AH2 + protoporphyrin IX
Cofactor	heme b Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
Pathway	Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.
Subunit	Homodimer.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Similarity	Belongs to the HemJ family.

Keywords [?]

Cell membrane
Heme
Iron
Membrane
Metal-binding
Oxidoreductase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0070818; Molecular function: protoporphyrinogen oxidase activity.
GO:0006779; Biological process: porphyrin-containing compound biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam	PF03653; UPF0093; 1;
PIRSF	PIRSF004638; UCP004638; 0-1;
NCBIfam	TIGR00701; TIGR00701; 1;

Computed features [?]

General

Transmembrane; -; 4-5; trigger=yes;

Features [?]

From: HEMJ_SYNY3 (P72793)

Key From To Description Tag Condition FTGroup

BINDING 27 27 /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue H

BINDING 108 108 /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue K

Additional information [?]

Size range	145-210 amino acids
Related rules	None
Fusion	None

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