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Annotation rule MF_02241 |
Accession | MF_02241 |
Dates | 19-DEC-2019 (Created) 19-DEC-2019 (Last updated, Version 2) |
Name | PIP_synthase |
Scope | Bacteria |
Templates | P9WPG7 (PIPS_MYCTU); A0A0H3MFZ3 (PIPS_MYCBP); Q9F7Y9 (PIPS_MYCS2): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Function | Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation. |
Catalytic activity | RHEA:60504: 1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+) |
RHEA:61216: 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+) | |
Cofactor | Mg(2+) Note: Contains a di-nuclear catalytic Mg(2+) center. |
Pathway | Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis. |
Subunit | Homodimer. |
Subcellular location | Cell membrane; Multi-pass membrane protein. |
Similarity | Belongs to the CDP-alcohol phosphatidyltransferase class-I family. |
General | Transmembrane; -; 6; trigger=yes; |
From: PIPS_MYCTU (P9WPG7) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 31 | 34 | CDP-DAG binding | [DN]-x-[VLIM]-T | ||||||||
ACT_SITE | 93 | 93 | Proton acceptor | D | ||||||||
METAL | 68 | 68 | Magnesium 1 | D | ||||||||
METAL | 68 | 68 | Magnesium 2 | D | ||||||||
METAL | 71 | 71 | Magnesium 1 | D | ||||||||
METAL | 89 | 89 | Magnesium 1 | D | ||||||||
METAL | 89 | 89 | Magnesium 2 | D | ||||||||
METAL | 93 | 93 | Magnesium 2 | D | ||||||||
BINDING | 72 | 72 | CDP-DAG; via amide nitrogen | G | ||||||||
BINDING | 76 | 76 | CDP-DAG | R | ||||||||
BINDING | 82 | 82 | CDP-DAG; via amide nitrogen | [TS] |
Size range | 190-290 amino acids |
Related rules | None |
Fusion | None |