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HAMAP rule MF_02242

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General rule information [?]

Accession MF_02242
Dates 19-DEC-2019 (Created)
19-NOV-2022 (Last updated, Version 5)
Name AIP_synthase
Templates O27726 (AIPS_METTH); Q7LXU6 (AIPS_SACS2); Q9YBS3 (AIPS_AERPE): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Archaetidylinositol phosphate synthase;
Short=AIP synthase;

Comments [?]

Function Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
Catalytic activity RHEA:36823: 1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol = CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate
Cofactor Mn(2+)
Note: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
Pathway Lipid metabolism; phospholipid metabolism.
Subcellular location Cell membrane; Multi-pass membrane protein.
Similarity Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Keywords [?]

Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0016780; Molecular function: phosphotransferase activity, for other substituted phosphate groups.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF01066; CDP-OH_P_transf; 1;

Computed features [?]

General Transmembrane; -; 4-5; trigger=yes;

Features [?]

From: AIPS_METTH (O27726)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     93     93       Proton acceptor     D  
BINDING     68     68       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1     D  
BINDING     68     68       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2     D  
BINDING     71     71       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1     D  
BINDING     89     89       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1     D  
BINDING     89     89       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2     D  
BINDING     93     93       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2     D  

Additional information [?]

Size range 160-250 amino acids
Related rules None
Fusion None