HAMAP rule MF_02242
General rule information
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| Accession | MF_02242 |
| Dates | 19-DEC-2019 (Created)
19-NOV-2022 (Last updated, Version 5) |
| Name | AIP_synthase |
| Scope(s) |
Archaea |
| Template(s) | O27726 (AIPS_METTH); Q7LXU6 (AIPS_SACS2); Q9YBS3 (AIPS_AERPE); [ Recover all ] |
| Triggered by |
HAMAP; MF_02242 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | AIPS |
| Protein name | RecName: Full=Archaetidylinositol phosphate synthase; Short=AIP synthase; EC=2.7.8.39; |
Comments
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| FUNCTION | Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn- glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3- phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea. |
| CATALYTIC ACTIVITY | Reaction=1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn- glycerol = CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3- phosphate; Xref=Rhea:RHEA:36823, ChEBI:CHEBI:15378, ChEBI:CHEBI:58401, ChEBI:CHEBI:60377, ChEBI:CHEBI:74004, ChEBI:CHEBI:74006; EC=2.7.8.39; |
| COFACTOR | Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 Mg(2+) or Mn(2+) ions per subunit.; |
| PATHWAY | Lipid metabolism; phospholipid metabolism. |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the CDP-alcohol phosphatidyltransferase class-I family. |
Keywords
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| Cell membrane |
| Lipid biosynthesis |
| Lipid metabolism |
| Magnesium |
| Manganese |
| Membrane |
| Metal-binding |
| Phospholipid metabolism |
| Transferase |
| Transmembrane |
| Transmembrane helix |
Gene Ontology
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| GO:0000287; Molecular function:magnesium ion binding |
| GO:0016780; Molecular function:phosphotransferase activity, for other substituted phosphate groups |
| GO:0008654; Biological process:phospholipid biosynthetic process |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| PROSITE | PS00379; CDP_ALCOHOL_P_TRANSF; 1; |
| Pfam | PF01066; CDP-OH_P_transf; 1; |
| General | Transmembrane; -; 4-5; |
Features
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| From: AIPS_METTH (O27726) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 93 | 93 | /note="Proton acceptor" | D | ||||||||
| BINDING | 68 | 68 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
D | ||||||||
| BINDING | 68 | 68 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
D | ||||||||
| BINDING | 71 | 71 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
D | ||||||||
| BINDING | 89 | 89 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
D | ||||||||
| BINDING | 89 | 89 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
D | ||||||||
| BINDING | 93 | 93 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
D | ||||||||
Additional information
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| Size range | 160-250 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |