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Annotation rule MF_02242
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General rule information [?]

Accession MF_02242
Dates 19-DEC-2019 (Created)
19-DEC-2019 (Last updated, Version 1)
Name AIP_synthase
Scope
Archaea
Templates O27726 (AIPS_METTH); Q7LXU6 (AIPS_SACS2); Q9YBS3 (AIPS_AERPE): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
AIPS
Protein name
RecName: Full=Archaetidylinositol phosphate synthase;
Short=AIP synthase;
EC 2.7.8.39;

Comments [?]

Function Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
Catalytic activity RHEA:36823: 1D-myo-inositol 3-phosphate + CDP-2,3-bis-(O-phytanyl)-sn-glycerol = CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate
EC 2.7.8.39
Cofactor Mn(2+)
Mg(2+)
Note: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
Pathway Lipid metabolism; phospholipid metabolism.
Subcellular location Cell membrane; Multi-pass membrane protein.
Similarity Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Keywords [?]


Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0016780; Molecular function: phosphotransferase activity, for other substituted phosphate groups.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0005887; Cellular component: integral component of plasma membrane.

Cross-references [?]

PROSITE PS00379; CDP_ALCOHOL_P_TRANSF; 1;
Pfam PF01066; CDP-OH_P_transf; 1;

Computed features [?]

General Transmembrane; -; 4-5; trigger=yes;

Features [?]

From: AIPS_METTH (O27726)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     93     93       Proton acceptor     D  
METAL     68     68       Magnesium 1     D  
METAL     68     68       Magnesium 2     D  
METAL     71     71       Magnesium 1     D  
METAL     89     89       Magnesium 1     D  
METAL     89     89       Magnesium 2     D  
METAL     93     93       Magnesium 2     D  

Additional information [?]

Size range 160-250 amino acids
Related rules None
Fusion None