HAMAP rule MF_02242

General rule information [?]

Accession	MF_02242
Dates	19-DEC-2019 (Created) 19-NOV-2022 (Last updated, Version 5)

Name	AIP_synthase

Scope

Archaea

Templates

O27726 (AIPS_METTH); Q7LXU6 (AIPS_SACS2); Q9YBS3 (AIPS_AERPE): [Recover all]

Triggered by

HAMAP; MF_02242 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

AIPS

Protein name

RecName:		Full=Archaetidylinositol phosphate synthase;
		Short=AIP synthase;
		EC 2.7.8.39;

Comments [?]

Function	Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
Catalytic activity	RHEA:36823: 1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol = CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate EC 2.7.8.39
Cofactor	Mn(2+) Mg(2+) Note: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
Pathway	Lipid metabolism; phospholipid metabolism.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Similarity	Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Keywords [?]

Cell membrane
Lipid biosynthesis
Lipid metabolism
Magnesium
Manganese
Membrane
Metal-binding
Phospholipid metabolism
Transferase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0016780; Molecular function: phosphotransferase activity, for other substituted phosphate groups.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

PROSITE	PS00379; CDP_ALCOHOL_P_TRANSF; 1;
Pfam	PF01066; CDP-OH_P_transf; 1;

Computed features [?]

General

Transmembrane; -; 4-5; trigger=yes;

Features [?]

From: AIPS_METTH (O27726)

Key From To Description Tag Condition FTGroup

ACT_SITE 93 93 Proton acceptor D

BINDING 68 68 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1 D

BINDING 68 68 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2 D

BINDING 71 71 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1 D

BINDING 89 89 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1 D

BINDING 89 89 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2 D

BINDING 93 93 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2 D

Additional information [?]

Size range	160-250 amino acids
Related rules	None
Fusion	None

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