HAMAP rule MF_02244
General rule information
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| Accession | MF_02244 |
| Dates | 20-MAR-2020 (Created)
13-JAN-2023 (Last updated, Version 4) |
| Name | Coproheme_decarbox_2 |
| Scope(s) |
Bacteria Actinomycetota |
| Template(s) | P9WL45 (CHDC_MYCTU); Q8Y5F1 (CHDC_LISMO); [ Recover all ] |
| Triggered by |
HAMAP; MF_02244 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CHDC |
| Protein name | RecName: Full=Coproheme decarboxylase; EC=1.3.98.5; AltName: Full=Coproheme III oxidative decarboxylase; AltName: Full=Hydrogen peroxide-dependent heme synthase; |
| Gene name | Name=chdC; |
Comments
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| FUNCTION | Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway. The reaction occurs in a stepwise manner with a three-propionate intermediate. |
| CATALYTIC ACTIVITY | Reaction=Fe-coproporphyrin III + 2 H(+) + 2 H2O2 = 2 CO2 + 4 H2O + heme b; Xref=Rhea:RHEA:56516, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16240, ChEBI:CHEBI:16526, ChEBI:CHEBI:60344, ChEBI:CHEBI:68438; EC=1.3.98.5; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56517; |
| CATALYTIC ACTIVITY | Reaction=Fe-coproporphyrin III + H(+) + H2O2 = CO2 + 2 H2O + harderoheme III; Xref=Rhea:RHEA:57940, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16240, ChEBI:CHEBI:16526, ChEBI:CHEBI:68438, ChEBI:CHEBI:142463; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57941; |
| CATALYTIC ACTIVITY | Reaction=H(+) + H2O2 + harderoheme III = CO2 + 2 H2O + heme b; Xref=Rhea:RHEA:57944, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16240, ChEBI:CHEBI:16526, ChEBI:CHEBI:60344, ChEBI:CHEBI:142463; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57945; |
| COFACTOR | Name=Fe-coproporphyrin III; Xref=ChEBI:CHEBI:68438; Note=Fe-coproporphyrin III acts as both substrate and redox cofactor; |
| PATHWAY | Porphyrin-containing compound metabolism; protoheme biosynthesis. |
| SIMILARITY | Belongs to the ChdC family. Type 2 subfamily. |
Keywords
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Gene Ontology
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| GO:0016634; Molecular function:oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor |
| GO:0006785; Biological process:heme B biosynthetic process |
Cross-references
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| Pfam | PF06778; Chlor_dismutase; 1; |
Features
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| From: CHDC_MYCTU (P9WL45) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 133 | 133 | Y | |||||||||
| BINDING | 156 | 156 | /ligand="Fe-coproporphyrin III" /ligand_id="ChEBI:CHEBI:68438" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue" |
H | ||||||||
Additional information
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| Size range | 200-290 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |