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HAMAP rule MF_02244

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General rule information [?]

Accession MF_02244
Dates 20-MAR-2020 (Created)
13-JAN-2023 (Last updated, Version 4)
Name Coproheme_decarbox_2
Scope
Bacteria; Actinomycetota
Templates P9WL45 (CHDC_MYCTU); Q8Y5F1 (CHDC_LISMO): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
CHDC
Protein name
RecName: Full=Coproheme decarboxylase;
EC 1.3.98.5;
AltName: Full=Coproheme III oxidative decarboxylase;
AltName: Full=Hydrogen peroxide-dependent heme synthase;
Gene name
chdC

Comments [?]

Function Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway. The reaction occurs in a stepwise manner with a three-propionate intermediate.
Catalytic activity RHEA:56516: Fe-coproporphyrin III + 2 H(+) + 2 H2O2 = 2 CO2 + 4 H2O + heme b
EC 1.3.98.5
PhysiologicalDirection=left-to-right (RHEA:56517)
RHEA:57940: Fe-coproporphyrin III + H(+) + H2O2 = CO2 + 2 H2O + harderoheme III
PhysiologicalDirection=left-to-right (RHEA:57941)
RHEA:57944: H(+) + H2O2 + harderoheme III = CO2 + 2 H2O + heme b
PhysiologicalDirection=left-to-right (RHEA:57945)
Cofactor Fe-coproporphyrin III
Note: Fe-coproporphyrin III acts as both substrate and redox cofactor;
Pathway Porphyrin-containing compound metabolism; protoheme biosynthesis.
Similarity Belongs to the ChdC family. Type 2 subfamily.

Keywords [?]

Heme
Heme biosynthesis
Iron
Metal-binding
Oxidoreductase

Gene Ontology [?]

GO:0016634; Molecular function: oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor.
GO:0006785; Biological process: heme B biosynthetic process.

Cross-references [?]

Pfam PF06778; Chlor_dismutase; 1;

Features [?]

From: CHDC_MYCTU (P9WL45)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     133     133             Y  
BINDING     156     156       /ligand="Fe-coproporphyrin III" /ligand_id="ChEBI:CHEBI:68438" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H  

Additional information [?]

Size range 200-290 amino acids
Related rules None
Fusion None


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