HAMAP rule MF_02244
General rule information
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Accession | MF_02244 |
Dates | 20-MAR-2020 (Created) 13-JAN-2023 (Last updated, Version 4) |
Name | Coproheme_decarbox_2 |
Scope | Bacteria; Actinomycetota |
Templates | P9WL45 (CHDC_MYCTU); Q8Y5F1 (CHDC_LISMO): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway. The reaction occurs in a stepwise manner with a three-propionate intermediate. |
Catalytic activity | RHEA:56516: Fe-coproporphyrin III + 2 H(+) + 2 H2O2 = 2 CO2 + 4 H2O + heme b
EC 1.3.98.5 PhysiologicalDirection=left-to-right (RHEA:56517) |
RHEA:57940: Fe-coproporphyrin III + H(+) + H2O2 = CO2 + 2 H2O + harderoheme III
PhysiologicalDirection=left-to-right (RHEA:57941) |
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RHEA:57944: H(+) + H2O2 + harderoheme III = CO2 + 2 H2O + heme b
PhysiologicalDirection=left-to-right (RHEA:57945) |
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Cofactor | Fe-coproporphyrin III Note: Fe-coproporphyrin III acts as both substrate and redox cofactor; |
Pathway | Porphyrin-containing compound metabolism; protoheme biosynthesis. |
Similarity | Belongs to the ChdC family. Type 2 subfamily. |
Keywords
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Gene Ontology
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GO:0016634; Molecular function: oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor.
GO:0006785; Biological process: heme B biosynthetic process.
GO:0006785; Biological process: heme B biosynthetic process.
Cross-references
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Pfam | PF06778; Chlor_dismutase; 1; |
Features
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From: CHDC_MYCTU (P9WL45) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 133 | 133 | Y | |||||||||
BINDING | 156 | 156 | /ligand="Fe-coproporphyrin III" /ligand_id="ChEBI:CHEBI:68438" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue | H |
Additional information
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Size range | 200-290 amino acids |
Related rules | None |
Fusion | None |