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HAMAP rule MF_02244

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General rule information [?]

Accession MF_02244
Dates 20-MAR-2020 (Created)
13-JAN-2023 (Last updated, Version 4)
Name Coproheme_decarbox_2
Scope(s) Bacteria
Actinomycetota
Template(s) P9WL45 (CHDC_MYCTU); Q8Y5F1 (CHDC_LISMO); [ Recover all ]
Triggered by HAMAP; MF_02244 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CHDC
Protein name RecName: Full=Coproheme decarboxylase;
                 EC=1.3.98.5;
AltName: Full=Coproheme III oxidative decarboxylase;
AltName: Full=Hydrogen peroxide-dependent heme synthase;
Gene name Name=chdC;

Comments [?]

FUNCTIONInvolved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway. The reaction occurs in a stepwise manner with a three-propionate intermediate.
CATALYTIC ACTIVITY Reaction=Fe-coproporphyrin III + 2 H(+) + 2 H2O2 = 2 CO2 + 4 H2O + heme b; Xref=Rhea:RHEA:56516, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16240, ChEBI:CHEBI:16526, ChEBI:CHEBI:60344, ChEBI:CHEBI:68438; EC=1.3.98.5; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56517;
CATALYTIC ACTIVITY Reaction=Fe-coproporphyrin III + H(+) + H2O2 = CO2 + 2 H2O + harderoheme III; Xref=Rhea:RHEA:57940, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16240, ChEBI:CHEBI:16526, ChEBI:CHEBI:68438, ChEBI:CHEBI:142463; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57941;
CATALYTIC ACTIVITY Reaction=H(+) + H2O2 + harderoheme III = CO2 + 2 H2O + heme b; Xref=Rhea:RHEA:57944, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16240, ChEBI:CHEBI:16526, ChEBI:CHEBI:60344, ChEBI:CHEBI:142463; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57945;
COFACTOR Name=Fe-coproporphyrin III; Xref=ChEBI:CHEBI:68438; Note=Fe-coproporphyrin III acts as both substrate and redox cofactor;
PATHWAYPorphyrin-containing compound metabolism; protoheme biosynthesis.
SIMILARITYBelongs to the ChdC family. Type 2 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0016634; Molecular function:oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
GO:0006785; Biological process:heme B biosynthetic process

Cross-references [?]

Pfam PF06778; Chlor_dismutase; 1;

Features [?]

From: CHDC_MYCTU (P9WL45)
Key From To Description Tag Condition FTGroup
ACT_SITE 133 133 Y
BINDING 156 156 /ligand="Fe-coproporphyrin III"
/ligand_id="ChEBI:CHEBI:68438"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"
H

Additional information [?]

Size range 200-290 amino acids
Related rules None
Fusion Nter: None Cter: None



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