HAMAP rule MF_02249

General rule information [?]

Accession	MF_02249
Dates	28-MAY-2021 (Created) 6-OCT-2022 (Last updated, Version 4)

Name

BioZ

Scope

Bacteria; Alphaproteobacteria

Bacteria; Bacteroidota

Templates

Q7CTU0 (BIOZ_AGRFC); Q2YKB4 (BIOZ_BRUA2); Q9EYU2 (BIOZ_RHILI); D0MCQ4 (BIOZ_RHOM4): [Recover all]

Triggered by

HAMAP; MF_02249 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

BIOZ

Protein name

RecName:		Full=3-oxopimeloyl-[acyl-carrier-protein] synthase;
		Short=3-oxopimeloyl-[ACP] synthase;
		EC 2.3.1.-;

Gene name

bioZ

Comments [?]

Function	Involved in the formation of the biotin precursor pimeloyl-ACP. Catalyzes the condensation of glutaryl-CoA, an intermediate in lysine degradation, with malonyl-ACP to produce 3-oxopimeloyl-ACP.
Catalytic activity	RHEA:44448: an acyl-CoA + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + CoA
	RHEA:67904: glutaryl-CoA + H(+) + malonyl-[ACP] = 3-oxo-6-carboxyhexanoyl-[ACP] + CO2 + CoA
Pathway	Cofactor biosynthesis; biotin biosynthesis.
Similarity	Belongs to the thiolase-like superfamily. BioZ family.

Keywords [?]

Acyltransferase
Biotin biosynthesis
Transferase

Gene Ontology [?]

GO:0016747; Molecular function: acyltransferase activity, transferring groups other than amino-acyl groups.
GO:0009102; Biological process: biotin biosynthetic process.

Cross-references [?]

Pfam	PF08541; ACP_syn_III_C; 1;
	PF08545; ACP_syn_III; 1;

Features [?]

From: BIOZ_AGRFC (Q7CTU0)

Key From To Description Tag Condition FTGroup

REGION 256 260 ACP-binding Q-A-N-x-R

ACT_SITE 115 115 C

ACT_SITE 255 255 H

ACT_SITE 285 285 N

Additional information [?]

Size range	300-365 amino acids
Related rules	None
Fusion	None

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