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HAMAP rule MF_02249

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General rule information [?]

Accession MF_02249
Dates 28-MAY-2021 (Created)
6-OCT-2022 (Last updated, Version 4)
Name BioZ
Bacteria; Alphaproteobacteria
Bacteria; Bacteroidota
Templates Q7CTU0 (BIOZ_AGRFC); Q2YKB4 (BIOZ_BRUA2); Q9EYU2 (BIOZ_RHILI); D0MCQ4 (BIOZ_RHOM4): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=3-oxopimeloyl-[acyl-carrier-protein] synthase;
Short=3-oxopimeloyl-[ACP] synthase;
EC 2.3.1.-;
Gene name

Comments [?]

Function Involved in the formation of the biotin precursor pimeloyl-ACP. Catalyzes the condensation of glutaryl-CoA, an intermediate in lysine degradation, with malonyl-ACP to produce 3-oxopimeloyl-ACP.
Catalytic activity RHEA:44448: an acyl-CoA + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + CoA
RHEA:67904: glutaryl-CoA + H(+) + malonyl-[ACP] = 3-oxo-6-carboxyhexanoyl-[ACP] + CO2 + CoA
Pathway Cofactor biosynthesis; biotin biosynthesis.
Similarity Belongs to the thiolase-like superfamily. BioZ family.

Keywords [?]

Gene Ontology [?]

GO:0016747; Molecular function: acyltransferase activity, transferring groups other than amino-acyl groups.
GO:0009102; Biological process: biotin biosynthetic process.

Cross-references [?]

Pfam PF08541; ACP_syn_III_C; 1;
PF08545; ACP_syn_III; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
REGION     256     260       ACP-binding     Q-A-N-x-R  
ACT_SITE     115     115             C  
ACT_SITE     255     255             H  
ACT_SITE     285     285             N  

Additional information [?]

Size range 300-365 amino acids
Related rules None
Fusion None