HAMAP rule MF_02249
General rule information
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Accession | MF_02249 |
Dates | 28-MAY-2021 (Created) 6-OCT-2022 (Last updated, Version 4) |
Name | BioZ |
Scope | Bacteria; Alphaproteobacteria
Bacteria; Bacteroidota |
Templates | Q7CTU0 (BIOZ_AGRFC); Q2YKB4 (BIOZ_BRUA2); Q9EYU2 (BIOZ_RHILI); D0MCQ4 (BIOZ_RHOM4): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Involved in the formation of the biotin precursor pimeloyl-ACP. Catalyzes the condensation of glutaryl-CoA, an intermediate in lysine degradation, with malonyl-ACP to produce 3-oxopimeloyl-ACP. |
Catalytic activity | RHEA:44448: an acyl-CoA + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + CoA |
RHEA:67904: glutaryl-CoA + H(+) + malonyl-[ACP] = 3-oxo-6-carboxyhexanoyl-[ACP] + CO2 + CoA | |
Pathway | Cofactor biosynthesis; biotin biosynthesis. |
Similarity | Belongs to the thiolase-like superfamily. BioZ family. |
Keywords
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Gene Ontology
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GO:0016747; Molecular function: acyltransferase activity, transferring groups other than amino-acyl groups.
GO:0009102; Biological process: biotin biosynthetic process.
GO:0009102; Biological process: biotin biosynthetic process.
Cross-references
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Features
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From: BIOZ_AGRFC (Q7CTU0) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 256 | 260 | ACP-binding | Q-A-N-x-R | ||||||||
ACT_SITE | 115 | 115 | C | |||||||||
ACT_SITE | 255 | 255 | H | |||||||||
ACT_SITE | 285 | 285 | N |
Additional information
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Size range | 300-365 amino acids |
Related rules | None |
Fusion | None |