HAMAP rule MF_02249

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_02249
Accession	MF_02249
Dates	28-MAY-2021 (Created) 02-SEP-2024 (Last updated, Version 6)
Name	BioZ
Scope(s)	Bacteria Alphaproteobacteria Bacteroidota
Template(s)	Q7CTU0; Q2YKB4; Q9EYU2; D0MCQ4; [ Recover all ]
Triggered by	HAMAP; MF_02249 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	BIOZ
Protein name	RecName: Full=3-oxopimeloyl-[acyl-carrier-protein] synthase; Short=3-oxopimeloyl-[ACP] synthase; EC=2.3.1.-;
Gene name	Name=bioZ;

Comments [?]

FUNCTION	Involved in the formation of the biotin precursor pimeloyl- ACP. Catalyzes the condensation of glutaryl-CoA, an intermediate in lysine degradation, with malonyl-ACP to produce 3-oxopimeloyl-ACP.
CATALYTIC ACTIVITY	Reaction=malonyl-[ACP] + an acyl-CoA + H(+) = a 3-oxoacyl-[ACP] + CO2 + CoA; Xref=Rhea:RHEA:44448, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9916, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:78449, ChEBI:CHEBI:78776;
CATALYTIC ACTIVITY	Reaction=glutaryl-CoA + malonyl-[ACP] + H(+) = 3-oxo-6-carboxyhexanoyl- [ACP] + CO2 + CoA; Xref=Rhea:RHEA:67904, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:17387, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57378, ChEBI:CHEBI:78449, ChEBI:CHEBI:176519;
PATHWAY	Cofactor biosynthesis; biotin biosynthesis.
SIMILARITY	Belongs to the thiolase-like superfamily. BioZ family.

Keywords [?]

Gene Ontology [?]

GO:0016747; Molecular function:acyltransferase activity, transferring groups other than amino-acyl groups

GO:0009102; Biological process:biotin biosynthetic process

Cross-references [?]

Pfam	PF08541; ACP_syn_III_C; 1;
Pfam	PF08545; ACP_syn_III; 1;

Features [?]

From: BIOZ_AGRFC (Q7CTU0)

Key

From

Description

Tag

Condition

FTGroup

REGION

256

260

/note="ACP-binding"

Q-A-N-x-R

ACT_SITE

115

ACT_SITE

255

ACT_SITE

285

Additional information [?]