HAMAP rule MF_02249
General rule information
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Accession | MF_02249 |
Dates | 28-MAY-2021 (Created)
6-OCT-2022 (Last updated, Version 4) |
Name | BioZ |
Scope(s) |
Bacteria Alphaproteobacteria Bacteroidota |
Template(s) | Q7CTU0 (BIOZ_AGRFC); Q2YKB4 (BIOZ_BRUA2); Q9EYU2 (BIOZ_RHILI); D0MCQ4 (BIOZ_RHOM4); [ Recover all ] |
Triggered by |
HAMAP; MF_02249 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | BIOZ |
Protein name | RecName: Full=3-oxopimeloyl-[acyl-carrier-protein] synthase; Short=3-oxopimeloyl-[ACP] synthase; EC=2.3.1.-; |
Gene name | Name=bioZ; |
Comments
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FUNCTION | Involved in the formation of the biotin precursor pimeloyl- ACP. Catalyzes the condensation of glutaryl-CoA, an intermediate in lysine degradation, with malonyl-ACP to produce 3-oxopimeloyl-ACP. |
CATALYTIC ACTIVITY | Reaction=an acyl-CoA + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + CoA; Xref=Rhea:RHEA:44448, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9916, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:78449, ChEBI:CHEBI:78776; |
CATALYTIC ACTIVITY | Reaction=glutaryl-CoA + H(+) + malonyl-[ACP] = 3-oxo-6-carboxyhexanoyl- [ACP] + CO2 + CoA; Xref=Rhea:RHEA:67904, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:17387, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57378, ChEBI:CHEBI:78449, ChEBI:CHEBI:176519; |
PATHWAY | Cofactor biosynthesis; biotin biosynthesis. |
SIMILARITY | Belongs to the thiolase-like superfamily. BioZ family. |
Keywords
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Gene Ontology
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GO:0016747; Molecular function:acyltransferase activity, transferring groups other than amino-acyl groups |
GO:0009102; Biological process:biotin biosynthetic process |
Cross-references
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Features
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From: BIOZ_AGRFC (Q7CTU0) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 256 | 260 | /note="ACP-binding" | Q-A-N-x-R | ||||||||
ACT_SITE | 115 | 115 | C | |||||||||
ACT_SITE | 255 | 255 | H | |||||||||
ACT_SITE | 285 | 285 | N |
Additional information
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Size range | 300-365 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |