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HAMAP rule MF_02249

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General rule information [?]

Accession MF_02249
Dates 28-MAY-2021 (Created)
6-OCT-2022 (Last updated, Version 4)
Name BioZ
Scope(s) Bacteria
Template(s) Q7CTU0 (BIOZ_AGRFC); Q2YKB4 (BIOZ_BRUA2); Q9EYU2 (BIOZ_RHILI); D0MCQ4 (BIOZ_RHOM4); [ Recover all ]
Triggered by HAMAP; MF_02249 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier BIOZ
Protein name RecName: Full=3-oxopimeloyl-[acyl-carrier-protein] synthase;
                 Short=3-oxopimeloyl-[ACP] synthase;
Gene name Name=bioZ;

Comments [?]

FUNCTIONInvolved in the formation of the biotin precursor pimeloyl- ACP. Catalyzes the condensation of glutaryl-CoA, an intermediate in lysine degradation, with malonyl-ACP to produce 3-oxopimeloyl-ACP.
CATALYTIC ACTIVITY Reaction=an acyl-CoA + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + CoA; Xref=Rhea:RHEA:44448, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9916, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:78449, ChEBI:CHEBI:78776;
CATALYTIC ACTIVITY Reaction=glutaryl-CoA + H(+) + malonyl-[ACP] = 3-oxo-6-carboxyhexanoyl- [ACP] + CO2 + CoA; Xref=Rhea:RHEA:67904, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:17387, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57378, ChEBI:CHEBI:78449, ChEBI:CHEBI:176519;
PATHWAYCofactor biosynthesis; biotin biosynthesis.
SIMILARITYBelongs to the thiolase-like superfamily. BioZ family.

Keywords [?]

Gene Ontology [?]

GO:0016747; Molecular function:acyltransferase activity, transferring groups other than amino-acyl groups
GO:0009102; Biological process:biotin biosynthetic process

Cross-references [?]

Pfam PF08541; ACP_syn_III_C; 1;
Pfam PF08545; ACP_syn_III; 1;

Features [?]

Key From To Description Tag Condition FTGroup
REGION 256 260 /note="ACP-binding" Q-A-N-x-R
ACT_SITE 115 115 C
ACT_SITE 255 255 H
ACT_SITE 285 285 N

Additional information [?]

Size range 300-365 amino acids
Related rules None
Fusion Nter: None Cter: None

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