HAMAP rule MF_02250
General rule information
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Accession | MF_02250 |
Dates | 5-MAY-2022 (Created) 1-JUN-2023 (Last updated, Version 5) |
Name | GMPR_GuaB1 |
Scope | Bacteria; Actinomycetota |
Templates | A0QYE8 (GUAB1_MYCS2); P9WKI3 (GUAB1_MYCTU): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Involved in the purine-salvage pathway. Catalyzes the NADPH-dependent conversion of GMP to IMP. |
Catalytic activity | RHEA:17185: IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH
EC 1.7.1.7 PhysiologicalDirection=right-to-left (RHEA:17187) |
Cofactor | a monovalent cation |
Pathway | Purine metabolism; IMP biosynthesis via salvage pathway. |
Similarity | Belongs to the IMPDH/GMPR family. GuaB1 subfamily. |
Keywords
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Gene Ontology
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GO:0003920; Molecular function: GMP reductase activity.
GO:0006163; Biological process: purine nucleotide metabolic process.
GO:0006163; Biological process: purine nucleotide metabolic process.
Cross-references
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PROSITE | PS51371; CBS; 2; trigger=PRU00703; |
Pfam | PF00478; IMPDH; 1; |
PF00571; CBS; 2; | |
PIRSF | PIRSF000130; IMPDH; 1; |
NCBIfam | TIGR01303; IMP_DH_rel_1; 1; |
Features
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From: GUAB1_MYCS2 (A0QYE8) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 245 | 247 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | D-T-A | ||||||||
BINDING | 295 | 297 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | [GN]-V-G | ||||||||
ACT_SITE | 302 | 302 | Thioimidate intermediate | C |
Additional information
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Size range | 450-550 amino acids |
Related rules | None |
Fusion | None |