HAMAP rule MF_02250

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_02250
Accession	MF_02250
Dates	05-MAY-2022 (Created) 02-SEP-2024 (Last updated, Version 8)
Name	GMPR_GuaB1
Scope(s)	Bacteria Actinomycetota
Template(s)	A0QYE8; P9WKI3; [ Recover all ]
Triggered by	HAMAP; MF_02250 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	GUAB1
Protein name	RecName: Full=GMP reductase; EC=1.7.1.7; AltName: Full=Guanosine 5'-monophosphate reductase; Short=GMPR;
Gene name	Name=guaB1;

Comments [?]

FUNCTION	Involved in the purine-salvage pathway. Catalyzes the NADPH- dependent conversion of GMP to IMP.
CATALYTIC ACTIVITY	Reaction=IMP + NH4(+) + NADP(+) = GMP + NADPH + 2 H(+); Xref=Rhea:RHEA:17185, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:57783, ChEBI:CHEBI:58053, ChEBI:CHEBI:58115, ChEBI:CHEBI:58349; EC=1.7.1.7; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:17187;
COFACTOR	Name=a monovalent cation; Xref=ChEBI:CHEBI:60242;
PATHWAY	Purine metabolism; IMP biosynthesis via salvage pathway.
SIMILARITY	Belongs to the IMPDH/GMPR family. GuaB1 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0003920; Molecular function:GMP reductase activity

GO:0032264; Biological process:IMP salvage

Cross-references [?]

Features [?]

From: GUAB1_MYCS2 (A0QYE8)

Key

From

Description

Tag

Condition

FTGroup

BINDING

245

247

/ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"

D-T-A

BINDING

295

297

/ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"

[GN]-V-G

ACT_SITE

302

/note="Thioimidate intermediate"

Additional information [?]