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Annotation rule MF_02250
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General rule information [?]

Accession MF_02250
Dates 5-MAY-2022 (Created)
13-JAN-2023 (Last updated, Version 4)
Name GMPR_GuaB1
Scope
Bacteria; Actinomycetota
Templates A0QYE8 (GUAB1_MYCS2); P9WKI3 (GUAB1_MYCTU): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GUAB1
Protein name
RecName: Full=GMP reductase;
EC 1.7.1.7;
AltName: Full=Guanosine 5'-monophosphate reductase;
Short=GMPR;
Gene name
guaB1

Comments [?]

Function Involved in the purine-salvage pathway. Catalyzes the NADPH-dependent conversion of GMP to IMP.
Catalytic activity RHEA:17185: IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH
EC 1.7.1.7
PhysiologicalDirection=right-to-left (RHEA:17187)
Cofactor a monovalent cation
Pathway Purine metabolism; IMP biosynthesis via salvage pathway.
Similarity Belongs to the IMPDH/GMPR family. GuaB1 subfamily.

Keywords [?]

NADP
Oxidoreductase
Purine salvage

Gene Ontology [?]

GO:0003920; Molecular function: GMP reductase activity.
GO:0006163; Biological process: purine nucleotide metabolic process.

Cross-references [?]

PROSITE PS51371; CBS; 2; trigger=PRU00703;
Pfam PF00478; IMPDH; 1;
PF00571; CBS; 2;
PIRSF PIRSF000130; IMPDH; 1;
TIGRFAMs TIGR01303; IMP_DH_rel_1; 1;

Features [?]

From: GUAB1_MYCS2 (A0QYE8)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     245     247       /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349     D-T-A  
BINDING     295     297       /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349     [GN]-V-G  
ACT_SITE     302     302       Thioimidate intermediate     C  

Additional information [?]

Size range 450-550 amino acids
Related rules None
Fusion None


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