HAMAP rule MF_02250

General rule information [?]

Accession	MF_02250
Dates	5-MAY-2022 (Created) 1-JUN-2023 (Last updated, Version 5)

Name	GMPR_GuaB1

Scope

Bacteria; Actinomycetota

Templates

A0QYE8 (GUAB1_MYCS2); P9WKI3 (GUAB1_MYCTU): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

GUAB1

Protein name

RecName:		Full=GMP reductase;
		EC 1.7.1.7;
AltName:		Full=Guanosine 5'-monophosphate reductase;
		Short=GMPR;

Gene name

guaB1

Comments [?]

Function	Involved in the purine-salvage pathway. Catalyzes the NADPH-dependent conversion of GMP to IMP.
Catalytic activity	RHEA:17185: IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH EC 1.7.1.7 PhysiologicalDirection=right-to-left (RHEA:17187)
Cofactor	a monovalent cation
Pathway	Purine metabolism; IMP biosynthesis via salvage pathway.
Similarity	Belongs to the IMPDH/GMPR family. GuaB1 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0003920; Molecular function: GMP reductase activity.
GO:0006163; Biological process: purine nucleotide metabolic process.

Cross-references [?]

Features [?]

From: GUAB1_MYCS2 (A0QYE8)

Key From To Description Tag Condition FTGroup

BINDING 245 247 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 D-T-A

BINDING 295 297 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 [GN]-V-G

ACT_SITE 302 302 Thioimidate intermediate C

Additional information [?]