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HAMAP rule MF_02250

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General rule information [?]

Accession MF_02250
Dates 5-MAY-2022 (Created)
1-JUN-2023 (Last updated, Version 5)
Name GMPR_GuaB1
Scope(s) Bacteria
Template(s) A0QYE8 (GUAB1_MYCS2); P9WKI3 (GUAB1_MYCTU); [ Recover all ]
Triggered by HAMAP; MF_02250 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GUAB1
Protein name RecName: Full=GMP reductase;
AltName: Full=Guanosine 5'-monophosphate reductase;
Gene name Name=guaB1;

Comments [?]

FUNCTIONInvolved in the purine-salvage pathway. Catalyzes the NADPH- dependent conversion of GMP to IMP.
CATALYTIC ACTIVITY Reaction=IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH; Xref=Rhea:RHEA:17185, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:57783, ChEBI:CHEBI:58053, ChEBI:CHEBI:58115, ChEBI:CHEBI:58349; EC=; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:17187;
COFACTOR Name=a monovalent cation; Xref=ChEBI:CHEBI:60242;
PATHWAYPurine metabolism; IMP biosynthesis via salvage pathway.
SIMILARITYBelongs to the IMPDH/GMPR family. GuaB1 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0003920; Molecular function:GMP reductase activity
GO:0006163; Biological process:purine nucleotide metabolic process

Cross-references [?]

PROSITE PS51371; CBS; 2;
Pfam PF00478; IMPDH; 1;
Pfam PF00571; CBS; 2;
NCBIfam TIGR01303; IMP_DH_rel_1; 1;

Features [?]

From: GUAB1_MYCS2 (A0QYE8)
Key From To Description Tag Condition FTGroup
BINDING 245 247 /ligand="NADP(+)"
BINDING 295 297 /ligand="NADP(+)"
ACT_SITE 302 302 /note="Thioimidate intermediate" C

Additional information [?]

Size range 450-550 amino acids
Related rules None
Fusion Nter: None Cter: None

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