HAMAP rule MF_03008
General rule information
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| Accession | MF_03008 |
| Dates | 30-JAN-2009 (Created)
20-NOV-2019 (Last updated, Version 13) |
| Name | eIF3i |
| Scope(s) |
Eukaryota |
| Template(s) | Q13347 (EIF3I_HUMAN); Q9QZD9 (EIF3I_MOUSE); P79083 (EIF3I_SCHPO); P40217 (EIF3I_YEAST); [ Recover all ] |
| Triggered by |
HAMAP; MF_03008 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | EIF3I |
| case <OC:Vertebrata> | |
| Protein name | RecName: Full=Eukaryotic translation initiation factor 3 subunit I; Short=eIF3i; AltName: Full=Eukaryotic translation initiation factor 3 subunit 2; AltName: Full=eIF-3-beta; AltName: Full=eIF3 p36; |
| else case <OC:Fungi> | |
| Protein name | RecName: Full=Eukaryotic translation initiation factor 3 subunit I; Short=eIF3i; AltName: Full=Eukaryotic translation initiation factor 3 39 kDa subunit homolog; Short=eIF-3 39 kDa subunit homolog; |
| else | |
| Protein name | RecName: Full=Eukaryotic translation initiation factor 3 subunit I; Short=eIF3i; |
| end case | |
| case <OC:Vertebrata> | |
| Gene name | Name=EIF3I; Synonyms=EIF3S2; |
| else case <OC:Drosophilidae> | |
| Gene name | Name=eIF3i; Synonyms=eif3-S2, Trip1; |
| else case <OC:Caenorhabditis> | |
| Gene name | Name=eif-3.I; |
| else case <OC:Fungi> | |
| Gene name | Name=TIF34; |
| end case | |
Comments
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| case <OC:Mammalia> | |
| FUNCTION | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. |
| else | |
| FUNCTION | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. |
| end case | |
| case <OC:Mammalia> | |
| SUBUNIT | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. |
| else case <OC:Vertebrata> and not <OC:Mammalia> | |
| SUBUNIT | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: @gn(EIF3A), @gn(EIF3B), @gn(EIF3C), @gn(EIF3D), @gn(EIF3E), @gn(EIF3F), @gn(EIF3G), @gn(EIF3H), @gn(EIF3I), @gn(EIF3J), @gn(EIF3K), @gn(EIF3L) and @gn(EIF3M). |
| else case <OC:Drosophilidae> | |
| SUBUNIT | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. |
| else | |
| SUBUNIT | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| case <OC:Mammalia> | |
| PTM | Phosphorylated by TGF-beta type II receptor. |
| end case | |
| SIMILARITY | Belongs to the eIF-3 subunit I family. |
Keywords
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| Cytoplasm | |
| Initiation factor | |
| Protein biosynthesis | |
| case <OC:Mammalia> | |
| Phosphoprotein | |
| end case | |
Gene Ontology
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| GO:0003743; Molecular function:translation initiation factor activity |
| GO:0001732; Biological process:formation of cytoplasmic translation initiation complex |
| GO:0002183; Biological process:cytoplasmic translational initiation |
| GO:0005737; Cellular component:cytoplasm |
| GO:0005852; Cellular component:eukaryotic translation initiation factor 3 complex |
| GO:0016282; Cellular component:eukaryotic 43S preinitiation complex |
| GO:0033290; Cellular component:eukaryotic 48S preinitiation complex |
Cross-references
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| PROSITE | PS00678; WD_REPEATS_1; 1; |
| PROSITE | PS50082; WD_REPEATS_2; 4; |
| PROSITE | PS50294; WD_REPEATS_REGION; 2; |
| Pfam | PF00400; WD40; 4; |
| REP | Repeat_WD40; WD40; 5-7; |
Features
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Additional information
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| Size range | 299-356 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |