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HAMAP rule MF_03013

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General rule information [?]

Accession MF_03013
Dates 12-FEB-2009 (Created)
20-NOV-2019 (Last updated, Version 10)
Name CLU
Scope
Eukaryota
Templates O15818 (CLU_DICDI); A1ZAB5 (CLU_DROME); Q03690 (CLU_YEAST): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
CLU
case <OC:Fungi>
Protein name
RecName: Full=Clustered mitochondria protein homolog;
AltName: Full=Protein TIF31 homolog;
else case <OC:Drosophilidae>
Protein name
RecName: Full=Protein clueless;
AltName: Full=Clustered mitochondria protein homolog;
else
Protein name
RecName: Full=Clustered mitochondria protein homolog;
end case
case <OC:Fungi>
Gene name
CLU1, TIF31
else case <OC:Drosophilidae>
Gene name
clu
else case <OC:Caenorhabditis>
Gene name
clu-1
else case <OC:Amoebozoa>
Gene name
cluA
end case

Comments [?]

case <OC:Vertebrata>
Function mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.
Subcellular location Cytoplasm. Cytoplasmic granule.
else
Function mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.
Subcellular location Cytoplasm.
end case
case <OC:Fungi>
Subunit May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.
end case
Similarity Belongs to the CLU family.

Keywords [?]

Cytoplasm
RNA-binding

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0007005; Biological process: mitochondrion organization.

Cross-references [?]

PROSITE PS51823; CLU; 1; trigger=PRU01167;
PS50293; TPR_REGION; 1;
PS50005; TPR; 1;
PS50312; ASP_RICH; 0-unlimited;
PS50313; GLU_RICH; 0-unlimited;
PS50318; LYS_RICH; 0-unlimited;
PS50323; ARG_RICH; 0-unlimited;
Pfam PF13236; CLU; 1;
PF00515; TPR_1; 1;

Computed features [?]

REP Repeat_TPR; TPR; 1-8;
General Coiled_coil; -; 0-unlimited;

Additional information [?]

Size range 1135-1502 amino acids
Related rules None
Fusion None


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