HAMAP rule MF_03014
General rule information
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Accession | MF_03014 |
Dates | 12-FEB-2009 (Created) 20-NOV-2019 (Last updated, Version 10) |
Name | KFase |
Scope | Eukaryota |
Templates | Q9VMC9 (KFA_DROME); Q8K4H1 (KFA_MOUSE); Q04066 (KFA_YEAST): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
Protein name |
|
case <OC:Vertebrata>
Gene name |
|
else case <OC:Saccharomycotina>
Gene name |
|
end case
Comments
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case <OC:Vertebrata> or <OC:Fungi>
Function | Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. |
else
Function | Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Required for elimination of toxic metabolites. |
end case
Catalytic activity | RHEA:13009: H2O + N-formyl-L-kynurenine = formate + H(+) + L-kynurenine
EC 3.5.1.9 |
Pathway | Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2. |
case <OC:Mammalia>
Subcellular location | Cytoplasm, cytosol. Nucleus. Note=Predominantly cytosolic. Some fraction is nuclear. |
else case <OC:Vertebrata> and not <OC:Mammalia>
Subcellular location | Cytoplasm, cytosol. Nucleus. |
end case
Subunit | Homodimer. |
case <FTTag:HGGXW>
Domain | The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage. |
end case
Similarity | Belongs to the kynurenine formamidase family. |
Keywords
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case <OC:Vertebrata>
end case
Gene Ontology
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GO:0004061; Molecular function: arylformamidase activity.
GO:0006569; Biological process: tryptophan catabolic process.
GO:0006569; Biological process: tryptophan catabolic process.
case <OC:Vertebrata> or <OC:Fungi>
GO:0034354; Biological process: 'de novo' NAD biosynthetic process from tryptophan.
end case
case <OC:Vertebrata>
end case
Features
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From: KFA_DROME (Q9VMC9) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOTIF | 86 | 90 | HGGXW | HGGXW | H-G-G-x-W | |||||||
ACT_SITE | 157 | 157 | Nucleophile | S | ||||||||
ACT_SITE | 244 | 244 | [DE] | |||||||||
ACT_SITE | 276 | 276 | H |
Additional information
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Size range | 241-399 amino acids |
Related rules | None |
Fusion | None |