HAMAP rule MF_03016

Accession	MF_03016
Dates	26-OCT-2009 (Created) 1-JUN-2023 (Last updated, Version 9)

Name	Ribosomal_S2_laminin_receptor

Scope

Eukaryota; Vertebrata

Templates

P08865 (RSSA_HUMAN); P14206 (RSSA_MOUSE); Q3ZM03 (RSSA_XENLA); P38982 (RSSA_CRIGR): [Recover all]

Triggered by

HAMAP; MF_03016 (Get profile general information and statistics)

Identifier

RSSA

Protein name

RecName: Full=Small ribosomal subunit protein uS2; AltName: Full=37 kDa laminin receptor precursor; Short=37LRP; AltName: Full=37/67 kDa laminin receptor; Short=LRP/LR; AltName: Full=67 kDa laminin receptor; Short=67LR; AltName: Full=Laminin receptor 1; Short=LamR; AltName: Full=Laminin-binding protein precursor p40; Short=LBP/p40;

Gene name

RPSA

Function	Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a @gn(PPP1R16B)-dependent substrate of @gn(PPP1CA).
Subunit	Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with @gn(RPS21). Interacts with several laminins including at least @gn(LAMB1). Interacts with @gn(MDK). The mature dimeric form interacts with @gn(PPP1R16B) (via its fourth ankyrin repeat). Interacts with @gn(PPP1CA) only in the presence of @gn(PPP1R16B).
Subcellular location	Cell membrane. Cytoplasm. Nucleus. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Co-localizes with @gn(PPP1R16B) in the cell membrane.

Function	Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis.
Subunit	Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with @gn(RPS21). Interacts with several laminins including at least @gn(LAMB1). Interacts with @gn(MDK).
Subcellular location	Cell membrane. Cytoplasm. Nucleus. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus.

Ptm	Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
	Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
Miscellaneous	This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.
Similarity	Belongs to the universal ribosomal protein uS2 family.

Acetylation

Cell membrane
Membrane
Receptor
Nucleus

Repeat

Cytoplasm
Ribonucleoprotein
Ribosomal protein

GO:0043236; Molecular function: laminin binding.
GO:0005055; Molecular function: laminin receptor activity.
GO:0007155; Biological process: cell adhesion.
GO:0022627; Cellular component: cytosolic small ribosomal subunit.
GO:0003735; Molecular function: structural constituent of ribosome.
GO:0000028; Biological process: ribosomal small subunit assembly.
GO:0006412; Biological process: translation.

PROSITE	PS00962; RIBOSOMAL_S2_1; 1;
	PS00963; RIBOSOMAL_S2_2; 1;
Pfam	PF00318; Ribosomal_S2; 1;
PRINTS	PR00395; RIBOSOMALS2; 1;
NCBIfam	TIGR01012; Sa_S2_E_A; 1;

From: RSSA_HUMAN (P08865)

Key

From

To

Description

Tag

Condition

FTGroup

INIT_MET

1

1

Removed

M

MOD_RES

2

2

N-acetylserine

acetyl

S

REPEAT

230

232

[DE]-W-[ST] 1

[DE]-W-[ST]

1

REPEAT

247

249

[DE]-W-[ST] 2

[DE]-W-[ST]

1

REPEAT

266

268

[DE]-W-[ST] 3

[DE]-W-[ST]

1

REPEAT

275

277

[DE]-W-[ST] 4

[DE]-W-[ST]

1

REPEAT

293

295

[DE]-W-[ST] 5

[DE]-W-[ST]

1

REGION

54

113

Interaction with @gn(PPP1R16B)

REGION		161		180		Laminin-binding
REGION		205		229		Laminin-binding
REGION		242		295		Laminin-binding
From: RSSA_XENLA (Q3ZM03)
SITE		115		116		Cleavage; by ST3; site 1				A-F
SITE		133		134		Cleavage; by ST3; site 2				P-[ILV]

Size range	295-317 amino acids
Related rules	MF_03015 (RSSA)
Fusion	None

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