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Annotation rule MF_03016
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General rule information [?]

Accession MF_03016
Dates 26-OCT-2009 (Created)
20-NOV-2019 (Last updated, Version 7)
Name Ribosomal_S2_laminin_receptor
Scope
Eukaryota; Vertebrata
Templates P08865 (RSSA_HUMAN); P14206 (RSSA_MOUSE); Q3ZM03 (RSSA_XENLA); P38982 (RSSA_CRIGR): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RSSA
Protein name
RecName: Full=40S ribosomal protein SA;
AltName: Full=37 kDa laminin receptor precursor;
Short=37LRP;
AltName: Full=37/67 kDa laminin receptor;
Short=LRP/LR;
AltName: Full=67 kDa laminin receptor;
Short=67LR;
AltName: Full=Laminin receptor 1;
Short=LamR;
AltName: Full=Laminin-binding protein precursor p40;
Short=LBP/p40;
Gene name
RPSA

Comments [?]

case <OC:Mammalia>
Function Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a @gn(PPP1R16B)-dependent substrate of @gn(PPP1CA).
Subunit Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with @gn(RPS21). Interacts with several laminins including at least @gn(LAMB1). Interacts with @gn(MDK). The mature dimeric form interacts with @gn(PPP1R16B) (via its fourth ankyrin repeat). Interacts with @gn(PPP1CA) only in the presence of @gn(PPP1R16B).
Subcellular location Cell membrane. Cytoplasm. Nucleus. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Co-localizes with @gn(PPP1R16B) in the cell membrane.
else case <OC:Vertebrata> and not <OC:Mammalia>
Function Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis.
Subunit Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with @gn(RPS21). Interacts with several laminins including at least @gn(LAMB1). Interacts with @gn(MDK).
Subcellular location Cell membrane. Cytoplasm. Nucleus. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus.
end case
Ptm Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
Miscellaneous This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.
Similarity Belongs to the universal ribosomal protein uS2 family.

Keywords [?]

case <FTTag:acetyl>
Acetylation
end case
Cell membrane
Membrane
Receptor
Nucleus
case <FTGroup:1>
Repeat
end case
Cytoplasm
Ribonucleoprotein
Ribosomal protein

Gene Ontology [?]

GO:0043236; Molecular function: laminin binding.
GO:0005055; Molecular function: laminin receptor activity.
GO:0007155; Biological process: cell adhesion.
GO:0022627; Cellular component: cytosolic small ribosomal subunit.
GO:0003735; Molecular function: structural constituent of ribosome.
GO:0000028; Biological process: ribosomal small subunit assembly.
GO:0006412; Biological process: translation.

Cross-references [?]

PROSITE PS00962; RIBOSOMAL_S2_1; 1;
PS00963; RIBOSOMAL_S2_2; 1;
Pfam PF00318; Ribosomal_S2; 1;
PRINTS PR00395; RIBOSOMALS2; 1;
TIGRFAMs TIGR01012; Sa_S2_E_A; 1;

Features [?]

From: RSSA_HUMAN (P08865)
Key     From     To       Description   Tag   Condition   FTGroup
INIT_MET     1     1       Removed     M  
MOD_RES     2     2       N-acetylserine   acetyl   S  
REPEAT     230     232       [DE]-W-[ST] 1     [DE]-W-[ST]   1
REPEAT     247     249       [DE]-W-[ST] 2     [DE]-W-[ST]   1
REPEAT     266     268       [DE]-W-[ST] 3     [DE]-W-[ST]   1
REPEAT     275     277       [DE]-W-[ST] 4     [DE]-W-[ST]   1
REPEAT     293     295       [DE]-W-[ST] 5     [DE]-W-[ST]   1
case <OC:Mammalia>
REGION     54     113       Interaction with @gn(PPP1R16B)        
end case
REGION     161     180       Laminin-binding        
REGION     205     229       Laminin-binding        
REGION     242     295       Laminin-binding        
From: RSSA_XENLA (Q3ZM03)
SITE     115     116       Cleavage; by ST3; site 1     A-F  
SITE     133     134       Cleavage; by ST3; site 2     P-[ILV]  

Additional information [?]

Size range 295-317 amino acids
Related rules MF_03015 (RSSA)
Fusion None


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