 |
|
Annotation rule MF_03016 |
General rule information
[?]
Accession |
MF_03016 |
Dates |
26-OCT-2009 (Created) 20-NOV-2019 (Last updated, Version 7) |
Name |
Ribosomal_S2_laminin_receptor |
Scope |
Eukaryota; Vertebrata |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
|
Full=40S ribosomal protein SA;
|
AltName:
|
Full=37 kDa laminin receptor precursor;
|
|
Short=37LRP;
|
AltName:
|
Full=37/67 kDa laminin receptor;
|
|
Short=LRP/LR;
|
AltName:
|
Full=67 kDa laminin receptor;
|
|
Short=67LR;
|
AltName:
|
Full=Laminin receptor 1;
|
|
Short=LamR;
|
AltName:
|
Full=Laminin-binding protein precursor p40;
|
|
Short=LBP/p40;
|
|
case <OC:Mammalia>
Function |
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a @gn(PPP1R16B)-dependent substrate of @gn(PPP1CA). |
Subunit |
Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with @gn(RPS21). Interacts with several laminins including at least @gn(LAMB1). Interacts with @gn(MDK). The mature dimeric form interacts with @gn(PPP1R16B) (via its fourth ankyrin repeat). Interacts with @gn(PPP1CA) only in the presence of @gn(PPP1R16B). |
Subcellular location |
Cell membrane. Cytoplasm. Nucleus. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Co-localizes with @gn(PPP1R16B) in the cell membrane. |
else case <OC:Vertebrata> and not <OC:Mammalia>
Function |
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. |
Subunit |
Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with @gn(RPS21). Interacts with several laminins including at least @gn(LAMB1). Interacts with @gn(MDK). |
Subcellular location |
Cell membrane. Cytoplasm. Nucleus. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. |
end case
Ptm |
Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association. |
|
Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions. |
Miscellaneous |
This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. |
Similarity |
Belongs to the universal ribosomal protein uS2 family. |
case <FTTag:acetyl>
end case
case <FTGroup:1>
end case
GO:0043236; Molecular function: laminin binding.
GO:0005055; Molecular function: laminin receptor activity.
GO:0007155; Biological process: cell adhesion.
GO:0022627; Cellular component: cytosolic small ribosomal subunit.
GO:0003735; Molecular function: structural constituent of ribosome.
GO:0000028; Biological process: ribosomal small subunit assembly.
GO:0006412; Biological process: translation.
From: RSSA_HUMAN (P08865) |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
INIT_MET
|
|
1
|
|
1
|
|
Removed
|
|
|
|
M
|
|
|
MOD_RES
|
|
2
|
|
2
|
|
N-acetylserine
|
|
acetyl
|
|
S
|
|
|
REPEAT
|
|
230
|
|
232
|
|
[DE]-W-[ST] 1
|
|
|
|
[DE]-W-[ST]
|
|
1
|
REPEAT
|
|
247
|
|
249
|
|
[DE]-W-[ST] 2
|
|
|
|
[DE]-W-[ST]
|
|
1
|
REPEAT
|
|
266
|
|
268
|
|
[DE]-W-[ST] 3
|
|
|
|
[DE]-W-[ST]
|
|
1
|
REPEAT
|
|
275
|
|
277
|
|
[DE]-W-[ST] 4
|
|
|
|
[DE]-W-[ST]
|
|
1
|
REPEAT
|
|
293
|
|
295
|
|
[DE]-W-[ST] 5
|
|
|
|
[DE]-W-[ST]
|
|
1
|
case <OC:Mammalia>
REGION
|
|
54
|
|
113
|
|
Interaction with @gn(PPP1R16B)
|
|
|
|
|
|
|
end case
REGION
|
|
161
|
|
180
|
|
Laminin-binding
|
|
|
|
|
|
|
REGION
|
|
205
|
|
229
|
|
Laminin-binding
|
|
|
|
|
|
|
REGION
|
|
242
|
|
295
|
|
Laminin-binding
|
|
|
|
|
|
|
From: RSSA_XENLA (Q3ZM03) |
SITE
|
|
115
|
|
116
|
|
Cleavage; by ST3; site 1
|
|
|
|
A-F
|
|
|
SITE
|
|
133
|
|
134
|
|
Cleavage; by ST3; site 2
|
|
|
|
P-[ILV]
|
|
|
Additional information
[?]
Size range |
295-317 amino acids |
Related rules |
MF_03015 (RSSA) |
Fusion |
None |