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HAMAP rule MF_03016

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General rule information [?]

PURL https://purl.expasy.org/hamap/rule/MF_03016
Accession MF_03016
Dates 25-SEP-2012 (Created)
01-JUN-2023 (Last updated, Version 10)
Name Ribosomal_S2_laminin_receptor
Scope(s) Eukaryota
Vertebrata
Template(s) P08865; P14206; Q3ZM03; P38982; [ Recover all ]
Triggered by HAMAP; MF_03016 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RSSA
Protein name RecName: Full=Small ribosomal subunit protein uS2;
AltName: Full=37 kDa laminin receptor precursor;
                 Short=37LRP;
AltName: Full=37/67 kDa laminin receptor;
                 Short=LRP/LR;
AltName: Full=67 kDa laminin receptor;
                 Short=67LR;
AltName: Full=Laminin receptor 1;
                 Short=LamR;
AltName: Full=Laminin-binding protein precursor p40;
                 Short=LBP/p40;
Gene name Name=RPSA;

Comments [?]

case <OC:Mammalia>
FUNCTIONRequired for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a @gn(PPP1R16B)-dependent substrate of @gn(PPP1CA).
SUBUNITMonomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with @gn(RPS21). Interacts with several laminins including at least @gn(LAMB1). Interacts with @gn(MDK). The mature dimeric form interacts with @gn(PPP1R16B) (via its fourth ankyrin repeat). Interacts with @gn(PPP1CA) only in the presence of @gn(PPP1R16B).
SUBCELLULAR LOCATIONCell membrane. Cytoplasm. Nucleus. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Co- localizes with @gn(PPP1R16B) in the cell membrane.
else case <OC:Vertebrata> and not <OC:Mammalia>
FUNCTIONRequired for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis.
SUBUNITMonomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with @gn(RPS21). Interacts with several laminins including at least @gn(LAMB1). Interacts with @gn(MDK).
SUBCELLULAR LOCATIONCell membrane. Cytoplasm. Nucleus. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus.
end case
PTMAcylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
PTMCleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
MISCELLANEOUSThis protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.
SIMILARITYBelongs to the universal ribosomal protein uS2 family.

Keywords [?]

case <FTTag:acetyl>
Acetylation
end case
Cell membrane
Membrane
Receptor
Nucleus
case <FTGroup:1>
Repeat
end case
Cytoplasm
Ribonucleoprotein
Ribosomal protein

Gene Ontology [?]

GO:0043236; Molecular function:laminin binding
GO:0005055; Molecular function:laminin receptor activity
GO:0007155; Biological process:cell adhesion
GO:0022627; Cellular component:cytosolic small ribosomal subunit
GO:0003735; Molecular function:structural constituent of ribosome
GO:0000028; Biological process:ribosomal small subunit assembly
GO:0006412; Biological process:translation

Cross-references [?]

PROSITE PS00962; RIBOSOMAL_S2_1; 1;
PROSITE PS00963; RIBOSOMAL_S2_2; 1;
Pfam PF00318; Ribosomal_S2; 1;
PRINTS PR00395; RIBOSOMALS2; 1;
NCBIfam TIGR01012; Sa_S2_E_A; 1;

Features [?]

From: RSSA_HUMAN (P08865)
Key From To Description Tag Condition FTGroup
INIT_MET 1 1 /note="Removed" M
MOD_RES 2 2 /note="N-acetylserine" acetyl S
REPEAT 230 232 /note="[DE]-W-[ST] 1" [DE]-W-[ST] 1
REPEAT 247 249 /note="[DE]-W-[ST] 2" [DE]-W-[ST] 1
REPEAT 266 268 /note="[DE]-W-[ST] 3" [DE]-W-[ST] 1
REPEAT 275 277 /note="[DE]-W-[ST] 4" [DE]-W-[ST] 1
REPEAT 293 295 /note="[DE]-W-[ST] 5" [DE]-W-[ST] 1
case <OC:Mammalia>
REGION 54 113 /note="Interaction with @gn(PPP1R16B)"
end case
REGION 161 180 /note="Laminin-binding"
REGION 205 229 /note="Laminin-binding"
REGION 242 295 /note="Laminin-binding"
From: RSSA_XENLA (Q3ZM03)
Key From To Description Tag Condition FTGroup
SITE 115 116 /note="Cleavage; by ST3; site 1" A-F
SITE 133 134 /note="Cleavage; by ST3; site 2" P-[ILV]

Additional information [?]

Size range 295-317 amino acids
Related rules MF_03015
Fusion Nter: None Cter: None



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