 |
|
Annotation rule MF_03018 |
General rule information
[?]
Accession |
MF_03018 |
Dates |
12-FEB-2009 (Created) 20-NOV-2019 (Last updated, Version 14) |
Name |
Kynurenine_monooxygenase_euk |
case <OC:Eukaryota>
end case
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Fungi>
Protein name |
RecName:
|
Full=Kynurenine 3-monooxygenase;
|
|
EC 1.14.13.9;
|
AltName:
|
Full=Biosynthesis of nicotinic acid protein 4;
|
AltName:
|
Full=Kynurenine 3-hydroxylase;
|
|
else
Protein name |
RecName:
|
Full=Kynurenine 3-monooxygenase;
|
|
EC 1.14.13.9;
|
AltName:
|
Full=Kynurenine 3-hydroxylase;
|
|
end case
case <OC:Dictyostelium>
else case <OC:Drosophilidae>
else case <OC:Fungi>
else case <OC:Eukaryota> and not <OC:Arthropoda> and not <OC:Nematoda>
end case
case <OC:Mammalia>
Function |
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. |
else
Function |
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. |
end case
Catalytic activity |
RHEA:20545: H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP(+)
EC 1.14.13.9
|
Cofactor |
FAD |
Pathway |
Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3. |
case <OC:Vertebrata>
Subcellular location |
Mitochondrion outer membrane; Multi-pass membrane protein. |
else case <OC:Arthropoda> or <OC:Nematoda>
Subcellular location |
Mitochondrion. Membrane; Multi-pass membrane protein. |
else case <OC:Fungi>
Subcellular location |
Mitochondrion outer membrane. |
else
Subcellular location |
Mitochondrion. |
end case
Similarity |
Belongs to the aromatic-ring hydroxylase family. KMO subfamily. |
case <OC:Vertebrata> or <OC:Arthropoda> or <OC:Nematoda> or <OC:Fungi>
end case
case <OC:Vertebrata> or <OC:Fungi>
end case
case <FTTag:transmembrane>
end case
GO:0004502; Molecular function: kynurenine 3-monooxygenase activity.
GO:0050660; Molecular function: flavin adenine dinucleotide binding.
GO:0006569; Biological process: tryptophan catabolic process.
GO:0019805; Biological process: quinolinate biosynthetic process.
GO:0034354; Biological process: 'de novo' NAD biosynthetic process from tryptophan.
GO:0043420; Biological process: anthranilate metabolic process.
case <OC:Vertebrata> or <OC:Arthropoda> or <OC:Nematoda> or <OC:Fungi>
GO:0031966; Cellular component: mitochondrial membrane.
else
end case
case <OC:Vertebrata>
From: KMO_HUMAN (O15229) |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
TRANSMEM
|
|
385
|
|
404
|
|
Helical
|
|
transmembrane
|
|
|
|
|
TRANSMEM
|
|
425
|
|
445
|
|
Helical
|
|
transmembrane
|
|
|
|
|
end case
case <OC:Arthropoda>
From: KMO_DROME (A1Z746) |
TRANSMEM
|
|
405
|
|
427
|
|
Helical
|
|
transmembrane
|
|
|
|
|
TRANSMEM
|
|
440
|
|
462
|
|
Helical
|
|
transmembrane
|
|
|
|
|
end case
case <OC:Nematoda>
From: KMO_CAEBR (A8Y432) |
TRANSMEM
|
|
395
|
|
415
|
|
Helical
|
|
transmembrane
|
|
|
|
|
TRANSMEM
|
|
432
|
|
452
|
|
Helical
|
|
transmembrane
|
|
|
|
|
end case
Additional information
[?]
Size range |
427-600 amino acids |
Related rules |
None |
Fusion |
None |