HAMAP logo

HAMAP rule MF_03018

Send feedback

General rule information [?]

Accession MF_03018
Dates 12-FEB-2009 (Created)
20-NOV-2019 (Last updated, Version 14)
Name Kynurenine_monooxygenase_euk
Scope
Eukaryota
Templates O15229 (KMO_HUMAN); Q91WN4 (KMO_MOUSE); O88867 (KMO_RAT); Q86PM2 (KMO_AEDAE); P38169 (KMO_YEAST): [Recover all]
case <OC:Eukaryota>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
KMO
case <OC:Fungi>
Protein name
RecName: Full=Kynurenine 3-monooxygenase;
EC 1.14.13.9;
AltName: Full=Biosynthesis of nicotinic acid protein 4;
AltName: Full=Kynurenine 3-hydroxylase;
else
Protein name
RecName: Full=Kynurenine 3-monooxygenase;
EC 1.14.13.9;
AltName: Full=Kynurenine 3-hydroxylase;
end case
case <OC:Dictyostelium>
Gene name
kmo
else case <OC:Drosophilidae>
Gene name
cn
else case <OC:Fungi>
Gene name
BNA4
else case <OC:Eukaryota> and not <OC:Arthropoda> and not <OC:Nematoda>
Gene name
KMO
end case

Comments [?]

case <OC:Mammalia>
Function Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
else
Function Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
end case
Catalytic activity RHEA:20545: H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP(+)
EC 1.14.13.9
Cofactor FAD
Pathway Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
case <OC:Vertebrata>
Subcellular location Mitochondrion outer membrane; Multi-pass membrane protein.
else case <OC:Arthropoda> or <OC:Nematoda>
Subcellular location Mitochondrion. Membrane; Multi-pass membrane protein.
else case <OC:Fungi>
Subcellular location Mitochondrion outer membrane.
else
Subcellular location Mitochondrion.
end case
Similarity Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Keywords [?]

FAD
Flavoprotein
Mitochondrion
case <OC:Vertebrata> or <OC:Arthropoda> or <OC:Nematoda> or <OC:Fungi>
Membrane
end case
case <OC:Vertebrata> or <OC:Fungi>
Mitochondrion outer membrane
end case
Monooxygenase
NADP
Oxidoreductase
Pyridine nucleotide biosynthesis
case <FTTag:transmembrane>
Transmembrane
Transmembrane helix
end case

Gene Ontology [?]

GO:0004502; Molecular function: kynurenine 3-monooxygenase activity.
GO:0050660; Molecular function: flavin adenine dinucleotide binding.
GO:0006569; Biological process: tryptophan catabolic process.
GO:0019805; Biological process: quinolinate biosynthetic process.
GO:0034354; Biological process: 'de novo' NAD biosynthetic process from tryptophan.
GO:0043420; Biological process: anthranilate metabolic process.
case <OC:Vertebrata> or <OC:Arthropoda> or <OC:Nematoda> or <OC:Fungi>
GO:0031966; Cellular component: mitochondrial membrane.
else
GO:0005739; Cellular component: mitochondrion.
end case

Cross-references [?]

Pfam PF01266; DAO; 1;
PRINTS PR00420; RNGMNOXGNASE; 1;

Features [?]

case <OC:Vertebrata>
From: KMO_HUMAN (O15229)
Key     From     To       Description   Tag   Condition   FTGroup
TRANSMEM     385     404       Helical   transmembrane      
TRANSMEM     425     445       Helical   transmembrane      
end case
case <OC:Arthropoda>
From: KMO_DROME (A1Z746)
TRANSMEM     405     427       Helical   transmembrane      
TRANSMEM     440     462       Helical   transmembrane      
end case
case <OC:Nematoda>
From: KMO_CAEBR (A8Y432)
TRANSMEM     395     415       Helical   transmembrane      
TRANSMEM     432     452       Helical   transmembrane      
end case

Additional information [?]

Size range 427-600 amino acids
Related rules None
Fusion None


View rule in raw text format (no links)