HAMAP rule MF_03018
General rule information
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Accession | MF_03018 |
Dates | 12-FEB-2009 (Created) 20-NOV-2019 (Last updated, Version 14) |
Name | Kynurenine_monooxygenase_euk |
Scope | Eukaryota |
Templates | O15229 (KMO_HUMAN); Q91WN4 (KMO_MOUSE); O88867 (KMO_RAT); Q86PM2 (KMO_AEDAE); P38169 (KMO_YEAST): [Recover all] |
case <OC:Eukaryota>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
case <OC:Fungi>
Protein name |
|
else
Protein name |
|
end case
case <OC:Dictyostelium>
Gene name |
|
else case <OC:Drosophilidae>
Gene name |
|
else case <OC:Fungi>
Gene name |
|
else case <OC:Eukaryota> and not <OC:Arthropoda> and not <OC:Nematoda>
Gene name |
|
end case
Comments
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case <OC:Mammalia>
Function | Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. |
else
Function | Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. |
end case
Catalytic activity | RHEA:20545: H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP(+)
EC 1.14.13.9 |
Cofactor | FAD |
Pathway | Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3. |
case <OC:Vertebrata>
Subcellular location | Mitochondrion outer membrane; Multi-pass membrane protein. |
else case <OC:Arthropoda> or <OC:Nematoda>
Subcellular location | Mitochondrion. Membrane; Multi-pass membrane protein. |
else case <OC:Fungi>
Subcellular location | Mitochondrion outer membrane. |
else
Subcellular location | Mitochondrion. |
end case
Similarity | Belongs to the aromatic-ring hydroxylase family. KMO subfamily. |
Keywords
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case <OC:Vertebrata> or <OC:Arthropoda> or <OC:Nematoda> or <OC:Fungi>
end case
case <OC:Vertebrata> or <OC:Fungi>
end case
case <FTTag:transmembrane>
end case
Gene Ontology
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GO:0004502; Molecular function: kynurenine 3-monooxygenase activity.
GO:0050660; Molecular function: flavin adenine dinucleotide binding.
GO:0006569; Biological process: tryptophan catabolic process.
GO:0019805; Biological process: quinolinate biosynthetic process.
GO:0034354; Biological process: 'de novo' NAD biosynthetic process from tryptophan.
GO:0043420; Biological process: anthranilate metabolic process.
GO:0050660; Molecular function: flavin adenine dinucleotide binding.
GO:0006569; Biological process: tryptophan catabolic process.
GO:0019805; Biological process: quinolinate biosynthetic process.
GO:0034354; Biological process: 'de novo' NAD biosynthetic process from tryptophan.
GO:0043420; Biological process: anthranilate metabolic process.
case <OC:Vertebrata> or <OC:Arthropoda> or <OC:Nematoda> or <OC:Fungi>
GO:0031966; Cellular component: mitochondrial membrane.
else
GO:0005739; Cellular component: mitochondrion.
end case
Cross-references
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Features
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case <OC:Vertebrata>
From: KMO_HUMAN (O15229) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
TRANSMEM | 385 | 404 | Helical | transmembrane | ||||||||
TRANSMEM | 425 | 445 | Helical | transmembrane |
end case
case <OC:Arthropoda>
From: KMO_DROME (A1Z746) | ||||||||||||
TRANSMEM | 405 | 427 | Helical | transmembrane | ||||||||
TRANSMEM | 440 | 462 | Helical | transmembrane |
end case
case <OC:Nematoda>
From: KMO_CAEBR (A8Y432) | ||||||||||||
TRANSMEM | 395 | 415 | Helical | transmembrane | ||||||||
TRANSMEM | 432 | 452 | Helical | transmembrane |
end case
Additional information
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Size range | 427-600 amino acids |
Related rules | None |
Fusion | None |