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|
Annotation rule MF_03019 |
General rule information
[?]
Accession |
MF_03019 |
Dates |
12-FEB-2009 (Created) 20-NOV-2019 (Last updated, Version 12) |
case <OC:Eukaryota>
end case
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Fungi>
Protein name |
RecName:
|
Full=3-hydroxyanthranilate 3,4-dioxygenase;
|
|
EC 1.13.11.6;
|
AltName:
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Full=3-hydroxyanthranilate oxygenase;
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Short=3-HAO;
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AltName:
|
Full=3-hydroxyanthranilic acid dioxygenase;
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|
Short=HAD;
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AltName:
|
Full=Biosynthesis of nicotinic acid protein 1;
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|
else
Protein name |
RecName:
|
Full=3-hydroxyanthranilate 3,4-dioxygenase;
|
|
EC 1.13.11.6;
|
AltName:
|
Full=3-hydroxyanthranilate oxygenase;
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|
Short=3-HAO;
|
AltName:
|
Full=3-hydroxyanthranilic acid dioxygenase;
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Short=HAD;
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|
end case
case <OC:Vertebrata>
else case <OC:Fungi>
end case
Function |
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. |
Catalytic activity |
RHEA:17953: 3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde
EC 1.13.11.6
|
case <FTGroup:1> or <FTGroup:2>
end case
Pathway |
Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. |
case <OC:Vertebrata>
end case
Subcellular location |
Cytoplasm. |
Similarity |
Belongs to the 3-HAO family. |
case <OC:Eukaryota>
end case
case <FTGroup:1> or <FTGroup:2>
end case
case <FTGroup:1> or <FTGroup:2> or <FTGroup:3>
end case
GO:0000334; Molecular function: 3-hydroxyanthranilate 3,4-dioxygenase activity.
GO:0008198; Molecular function: ferrous iron binding.
GO:0006569; Biological process: tryptophan catabolic process.
GO:0019805; Biological process: quinolinate biosynthetic process.
GO:0034354; Biological process: 'de novo' NAD biosynthetic process from tryptophan.
GO:0043420; Biological process: anthranilate metabolic process.
case <OC:Eukaryota>
end case
case <OC:Metazoa>
From: 3HAO_BOVIN (Q0VCA8) |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
REGION
|
|
Nter
|
|
160
|
|
Domain A (catalytic)
|
|
|
|
|
|
|
REGION
|
|
161
|
|
177
|
|
Linker
|
|
|
|
|
|
|
REGION
|
|
178
|
|
Cter
|
|
Domain B
|
|
|
|
|
|
|
METAL
|
|
47
|
|
47
|
|
Iron; catalytic
|
|
|
|
H
|
|
1
|
METAL
|
|
53
|
|
53
|
|
Iron; catalytic
|
|
|
|
E
|
|
1
|
METAL
|
|
91
|
|
91
|
|
Iron; catalytic
|
|
|
|
H
|
|
1
|
BINDING
|
|
43
|
|
43
|
|
Dioxygen
|
|
|
|
R
|
|
|
BINDING
|
|
53
|
|
53
|
|
Substrate
|
|
|
|
E
|
|
|
BINDING
|
|
95
|
|
95
|
|
Substrate
|
|
|
|
R
|
|
|
BINDING
|
|
105
|
|
105
|
|
Substrate
|
|
|
|
E
|
|
|
end case
case <OC:Fungi>
From: 3HAO_YEAST (P47096) |
METAL
|
|
49
|
|
49
|
|
Iron; catalytic
|
|
|
|
H
|
|
2
|
METAL
|
|
55
|
|
55
|
|
Iron; catalytic
|
|
|
|
E
|
|
2
|
METAL
|
|
97
|
|
97
|
|
Iron; catalytic
|
|
|
|
H
|
|
2
|
METAL
|
|
126
|
|
126
|
|
Divalent metal cation
|
|
|
|
C
|
|
3
|
METAL
|
|
129
|
|
129
|
|
Divalent metal cation
|
|
|
|
C
|
|
3
|
METAL
|
|
163
|
|
163
|
|
Divalent metal cation
|
|
|
|
C
|
|
3
|
METAL
|
|
166
|
|
166
|
|
Divalent metal cation
|
|
|
|
C
|
|
3
|
BINDING
|
|
45
|
|
45
|
|
Dioxygen
|
|
|
|
R
|
|
|
BINDING
|
|
55
|
|
55
|
|
Substrate
|
|
|
|
E
|
|
|
BINDING
|
|
101
|
|
101
|
|
Substrate
|
|
|
|
R
|
|
|
BINDING
|
|
111
|
|
111
|
|
Substrate
|
|
|
|
E
|
|
|
end case
Additional information
[?]
Size range |
160-288 amino acids |
Related rules |
None |
Fusion |
None |