HAMAP rule MF_03019
General rule information
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Accession | MF_03019 |
Dates | 12-FEB-2009 (Created) 1-JUN-2023 (Last updated, Version 15) |
Name | 3_HAO_euk |
Scope | Eukaryota |
Templates | Q0VCA8 (3HAO_BOVIN); Q78JT3 (3HAO_MOUSE); Q54S02 (3HAO_DICDI); P46952 (3HAO_HUMAN); P47096 (3HAO_YEAST): [Recover all] |
case <OC:Eukaryota>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
case <OC:Fungi>
Protein name |
|
else
Protein name |
|
end case
case <OC:Vertebrata>
Gene name |
|
else case <OC:Fungi>
Gene name |
|
end case
Comments
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Function | Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. |
Catalytic activity | RHEA:17953: 3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde
EC 1.13.11.6 |
case <FTGroup:1> or <FTGroup:2>
Cofactor | Fe(2+) |
end case
Pathway | Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. |
case <OC:Vertebrata>
Subunit | Monomer. |
end case
Subcellular location | Cytoplasm. |
Similarity | Belongs to the 3-HAO family. |
Keywords
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case <OC:Eukaryota>
end case
case <FTGroup:1> or <FTGroup:2>
end case
case <FTGroup:1> or <FTGroup:2> or <FTGroup:3>
end case
Gene Ontology
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GO:0000334; Molecular function: 3-hydroxyanthranilate 3,4-dioxygenase activity.
GO:0008198; Molecular function: ferrous iron binding.
GO:0006569; Biological process: tryptophan catabolic process.
GO:0019805; Biological process: quinolinate biosynthetic process.
GO:0034354; Biological process: 'de novo' NAD biosynthetic process from tryptophan.
GO:0043420; Biological process: anthranilate metabolic process.
GO:0008198; Molecular function: ferrous iron binding.
GO:0006569; Biological process: tryptophan catabolic process.
GO:0019805; Biological process: quinolinate biosynthetic process.
GO:0034354; Biological process: 'de novo' NAD biosynthetic process from tryptophan.
GO:0043420; Biological process: anthranilate metabolic process.
case <OC:Eukaryota>
GO:0005737; Cellular component: cytoplasm.
end case
Cross-references
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Features
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case <OC:Metazoa>
From: 3HAO_BOVIN (Q0VCA8) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | Nter | 160 | Domain A (catalytic) | |||||||||
REGION | 161 | 177 | Linker | |||||||||
REGION | 178 | Cter | Domain B | |||||||||
BINDING | 47 | 47 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 53 | 53 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_note="catalytic | E | 1 | |||||||
BINDING | 91 | 91 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 43 | 43 | /ligand="O2" /ligand_id="ChEBI:CHEBI:15379 | R | ||||||||
BINDING | 53 | 53 | /ligand="substrate | E | ||||||||
BINDING | 95 | 95 | /ligand="substrate | R | ||||||||
BINDING | 105 | 105 | /ligand="substrate | E |
end case
case <OC:Fungi>
From: 3HAO_YEAST (P47096) | ||||||||||||
BINDING | 49 | 49 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_note="catalytic | H | 2 | |||||||
BINDING | 55 | 55 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_note="catalytic | E | 2 | |||||||
BINDING | 97 | 97 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_note="catalytic | H | 2 | |||||||
BINDING | 126 | 126 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | C | 3 | |||||||
BINDING | 129 | 129 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | C | 3 | |||||||
BINDING | 163 | 163 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | C | 3 | |||||||
BINDING | 166 | 166 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | C | 3 | |||||||
BINDING | 45 | 45 | /ligand="O2" /ligand_id="ChEBI:CHEBI:15379 | R | ||||||||
BINDING | 55 | 55 | /ligand="substrate | E | ||||||||
BINDING | 101 | 101 | /ligand="substrate | R | ||||||||
BINDING | 111 | 111 | /ligand="substrate | E |
end case
Additional information
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Size range | 160-288 amino acids |
Related rules | None |
Fusion | None |