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HAMAP rule MF_03022
General rule information
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| Accession | MF_03022 |
| Dates | 23-FEB-2009 (Created)
20-NOV-2019 (Last updated, Version 11) |
| Name | Katanin_p80_B1 |
| Scope(s) |
Eukaryota |
| Template(s) | Q9BVA0 (KTNB1_HUMAN); Q8BG40 (KTNB1_MOUSE); Q4V7Y7 (KTNB1_XENLA); O61585 (KTNB1_STRPU); [ Recover all ] |
| Triggered by |
HAMAP; MF_03022 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | KTNB1 |
| case <OC:Metazoa> | |
| Protein name | RecName: Full=Katanin p80 WD40 repeat-containing subunit B1; Short=Katanin p80 subunit B1; AltName: Full=p80 katanin; |
| Gene name | Name=KATNB1; |
| else | |
| Protein name | RecName: Full=Katanin p80 WD40 repeat-containing subunit B1 homolog; |
| end case | |
Comments
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| case <OC:Mammalia> | |
| FUNCTION | Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. |
| else case <OC:Metazoa> | |
| FUNCTION | Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. |
| else | |
| FUNCTION | May participate in a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays. |
| end case | |
| case <OC:Mammalia> | |
| SUBUNIT | Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. This interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein, microtubules, NDEL1 and PAFAH1B1. Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches. |
| else case <OC:Metazoa> | |
| SUBUNIT | Interacts with @gn(KATNA1). This interaction enhances the microtubule binding and severing activity of @gn(KATNA1) and also targets this activity to the centrosome. |
| end case | |
| case <OC:Mammalia> | |
| SUBCELLULAR LOCATION | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles. Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis. |
| else case <OC:Metazoa> | |
| SUBCELLULAR LOCATION | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles. |
| else | |
| SUBCELLULAR LOCATION | Cytoplasm, cytoskeleton. |
| end case | |
| SIMILARITY | Belongs to the WD repeat KATNB1 family. |
Keywords
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| Cytoplasm | |
| Cytoskeleton | |
| Microtubule | |
| case <OC:Metazoa> | |
| Cell cycle | |
| Cell division | |
| Mitosis | |
| end case | |
Gene Ontology
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| GO:0008017; Molecular function:microtubule binding | |
| GO:0051013; Biological process:microtubule severing | |
| GO:0005737; Cellular component:cytoplasm | |
| case <OCellular component:Mammalia> | |
| GO:0031117; Biological process:positive regulation of microtubule depolymerization | |
| GO:0007079; Biological process:mitotic chromosome movement towards spindle pole | |
| end case | |
| case <OCellular component:Metazoa> | |
| GO:0005813; Cellular component:centrosome | |
| GO:0005819; Cellular component:spindle | |
| end case | |
Cross-references
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| PROSITE | PS00678; WD_REPEATS_1; 3; |
| PROSITE | PS50082; WD_REPEATS_2; 5; |
| PROSITE | PS50294; WD_REPEATS_REGION; 1; |
| Pfam | PF00400; WD40; 6; |
| PRINTS | PR00320; GPROTEINBRPT; 1; |
| REP | Repeat_WD40; WD40; 6; |
Features
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Additional information
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| Size range | 578-934 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |