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Annotation rule MF_03024
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General rule information [?]

Accession MF_03024
Dates 20-FEB-2009 (Created)
20-NOV-2019 (Last updated, Version 12)
Name Katanin_p60_AL1
Scope
Eukaryota; Vertebrata
Template Q9BW62 (KATL1_HUMAN)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
KATL1
Protein name
RecName: Full=Katanin p60 ATPase-containing subunit A-like 1;
Short=Katanin p60 subunit A-like 1;
EC 5.6.1.1;
AltName: Full=p60 katanin-like 1;
Gene name
KATNAL1

Comments [?]

Function Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.
Catalytic activity Reaction=n ATP + n H(2)O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=5.6.1.1;
case <OC:Mammalia>
Subunit Interacts with KATNB1 and KATNBL1.
end case
Subcellular location Cytoplasm, cytoskeleton. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with microtubules throughout the basal and adluminal compartments of Sertoli cells. Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis.
Similarity Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.

Keywords [?]

ATP-binding
Cytoplasm
Cytoskeleton
Isomerase
Microtubule
Nucleotide-binding

Gene Ontology [?]

GO:0008017; Molecular function: microtubule binding.
GO:0051013; Biological process: microtubule severing.
GO:0005737; Cellular component: cytoplasm.
GO:0007283; Biological process: spermatogenesis.

Cross-references [?]

PROSITE PS00674; AAA; 1;
Pfam PF00004; AAA; 1;

Features [?]

From: KATL1_HUMAN (Q9BW62)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     248     255       ATP     G-P-P-G-T-G-K-T  

Additional information [?]

Size range 487-491 amino acids
Related rules None
Fusion None


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