HAMAP rule MF_03024
General rule information
[?]
| Accession | MF_03024 |
| Dates | 20-FEB-2009 (Created)
19-NOV-2022 (Last updated, Version 15) |
| Name | Katanin_p60_AL1 |
| Scope(s) |
Eukaryota Vertebrata |
| Template(s) | Q9BW62 (KATL1_HUMAN); [ Recover all ] |
| Triggered by |
HAMAP; MF_03024 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | KATL1 |
| Protein name | RecName: Full=Katanin p60 ATPase-containing subunit A-like 1; Short=Katanin p60 subunit A-like 1; EC=5.6.1.1; AltName: Full=p60 katanin-like 1; |
| Gene name | Name=KATNAL1; |
Comments
[?]
| FUNCTION | Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays. |
| CATALYTIC ACTIVITY | Reaction=n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=5.6.1.1; |
| case <OC:Mammalia> | |
| SUBUNIT | Interacts with KATNB1 and KATNBL1. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm, cytoskeleton. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with microtubules throughout the basal and adluminal compartments of Sertoli cells. Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis. |
| SIMILARITY | Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily. |
Keywords
[?]
Gene Ontology
[?]
| GO:0008017; Molecular function:microtubule binding |
| GO:0051013; Biological process:microtubule severing |
| GO:0005737; Cellular component:cytoplasm |
| GO:0007283; Biological process:spermatogenesis |
Cross-references
[?]
Features
[?]
| From: KATL1_HUMAN (Q9BW62) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 248 | 255 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-P-P-G-T-G-K-T | ||||||||
Additional information
[?]
| Size range | 487-491 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |