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HAMAP rule MF_03024

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General rule information [?]

Accession MF_03024
Dates 20-FEB-2009 (Created)
19-NOV-2022 (Last updated, Version 15)
Name Katanin_p60_AL1
Scope(s) Eukaryota
Template(s) Q9BW62 (KATL1_HUMAN); [ Recover all ]
Triggered by HAMAP; MF_03024 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier KATL1
Protein name RecName: Full=Katanin p60 ATPase-containing subunit A-like 1;
                 Short=Katanin p60 subunit A-like 1;
AltName: Full=p60 katanin-like 1;
Gene name Name=KATNAL1;

Comments [?]

FUNCTIONRegulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.
CATALYTIC ACTIVITY Reaction=n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=;
case <OC:Mammalia>
SUBUNITInteracts with KATNB1 and KATNBL1.
end case
SUBCELLULAR LOCATIONCytoplasm, cytoskeleton. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with microtubules throughout the basal and adluminal compartments of Sertoli cells. Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis.
SIMILARITYBelongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008017; Molecular function:microtubule binding
GO:0051013; Biological process:microtubule severing
GO:0005737; Cellular component:cytoplasm
GO:0007283; Biological process:spermatogenesis

Cross-references [?]

PROSITE PS00674; AAA; 1;
Pfam PF00004; AAA; 1;

Features [?]

From: KATL1_HUMAN (Q9BW62)
Key From To Description Tag Condition FTGroup
BINDING 248 255 /ligand="ATP"

Additional information [?]

Size range 487-491 amino acids
Related rules None
Fusion Nter: None Cter: None

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