![]() |
|
Annotation rule MF_03024 |
Accession | MF_03024 |
Dates | 20-FEB-2009 (Created) 20-NOV-2019 (Last updated, Version 12) |
Name | Katanin_p60_AL1 |
Scope | Eukaryota; Vertebrata |
Template | Q9BW62 (KATL1_HUMAN) |
Triggered by |
Identifier |
|
Protein name |
|
Gene name |
|
Function | Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays. |
Catalytic activity | Reaction=n ATP + n H(2)O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=5.6.1.1; |
Subunit | Interacts with KATNB1 and KATNBL1. |
Subcellular location | Cytoplasm, cytoskeleton. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with microtubules throughout the basal and adluminal compartments of Sertoli cells. Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis. |
Similarity | Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily. |
From: KATL1_HUMAN (Q9BW62) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND | 248 | 255 | ATP | G-P-P-G-T-G-K-T |
Size range | 487-491 amino acids |
Related rules | None |
Fusion | None |