HAMAP rule MF_03025

General rule information [?]

Accession	MF_03025
Dates	9-OCT-2012 (Created) 19-NOV-2022 (Last updated, Version 12)

Name	Katanin_p60_AL2

Scope

Eukaryota

Template

Q8IYT4 (KATL2_HUMAN)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

KATL2

Protein name

RecName:		Full=Katanin p60 ATPase-containing subunit A-like 2;
		Short=Katanin p60 subunit A-like 2;
		EC 5.6.1.1;
AltName:		Full=p60 katanin-like 2;

Gene name

KATNAL2

Comments [?]

Function	Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
Catalytic activity	Reaction=n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=5.6.1.1;
Subcellular location	Cytoplasm, cytoskeleton. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis.
Similarity	Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008017; Molecular function: microtubule binding.
GO:0051013; Biological process: microtubule severing.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Features [?]

From: KATL2_HUMAN (Q8IYT4)

Key From To Description Tag Condition FTGroup

BINDING 294 301 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 G-P-P-[GD]-[TLN]-G-K-T

Additional information [?]