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Annotation rule MF_03025
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General rule information [?]

Accession MF_03025
Dates 9-OCT-2012 (Created)
20-NOV-2019 (Last updated, Version 9)
Name Katanin_p60_AL2
Scope
Eukaryota
Template Q8IYT4 (KATL2_HUMAN)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
KATL2
Protein name
RecName: Full=Katanin p60 ATPase-containing subunit A-like 2;
Short=Katanin p60 subunit A-like 2;
EC 5.6.1.1;
AltName: Full=p60 katanin-like 2;
Gene name
KATNAL2

Comments [?]

Function Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
Catalytic activity Reaction=n ATP + n H(2)O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=5.6.1.1;
Subcellular location Cytoplasm, cytoskeleton. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis.
Similarity Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.

Keywords [?]

ATP-binding
Cytoplasm
Cytoskeleton
Isomerase
Microtubule
Nucleotide-binding

Gene Ontology [?]

GO:0008017; Molecular function: microtubule binding.
GO:0051013; Biological process: microtubule severing.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS00674; AAA; 1;
PS50896; LISH; 1; trigger=PRU00126;
Pfam PF00004; AAA; 1;
PF08513; LisH; 1;

Features [?]

From: KATL2_HUMAN (Q8IYT4)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     294     301       ATP     G-P-P-[GD]-[TLN]-G-K-T  

Additional information [?]

Size range 403-603 amino acids
Related rules None
Fusion None


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