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HAMAP rule MF_03025

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General rule information [?]

Accession MF_03025
Dates 9-OCT-2012 (Created)
19-NOV-2022 (Last updated, Version 12)
Name Katanin_p60_AL2
Template Q8IYT4 (KATL2_HUMAN)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Katanin p60 ATPase-containing subunit A-like 2;
Short=Katanin p60 subunit A-like 2;
AltName: Full=p60 katanin-like 2;
Gene name

Comments [?]

Function Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
Catalytic activity Reaction=n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=;
Subcellular location Cytoplasm, cytoskeleton. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis.
Similarity Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008017; Molecular function: microtubule binding.
GO:0051013; Biological process: microtubule severing.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS00674; AAA; 1;
PS50896; LISH; 1; trigger=PRU00126;
Pfam PF00004; AAA; 1;
PF08513; LisH; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
BINDING     294     301       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     G-P-P-[GD]-[TLN]-G-K-T  

Additional information [?]

Size range 403-603 amino acids
Related rules None
Fusion None