HAMAP rule MF_03025
General rule information
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| Accession | MF_03025 |
| Dates | 9-OCT-2012 (Created)
19-NOV-2022 (Last updated, Version 12) |
| Name | Katanin_p60_AL2 |
| Scope(s) |
Eukaryota |
| Template(s) | Q8IYT4 (KATL2_HUMAN); [ Recover all ] |
| Triggered by |
HAMAP; MF_03025 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | KATL2 |
| Protein name | RecName: Full=Katanin p60 ATPase-containing subunit A-like 2; Short=Katanin p60 subunit A-like 2; EC=5.6.1.1; AltName: Full=p60 katanin-like 2; |
| Gene name | Name=KATNAL2; |
Comments
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| FUNCTION | Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. |
| CATALYTIC ACTIVITY | Reaction=n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=5.6.1.1; |
| SUBCELLULAR LOCATION | Cytoplasm, cytoskeleton. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis. |
| SIMILARITY | Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily. |
Keywords
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Gene Ontology
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| GO:0008017; Molecular function:microtubule binding |
| GO:0051013; Biological process:microtubule severing |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: KATL2_HUMAN (Q8IYT4) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 294 | 301 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-P-P-[GD]-[TLN]-G-K-T | ||||||||
Additional information
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| Size range | 403-603 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |