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Annotation rule MF_03025 |
Accession | MF_03025 |
Dates | 9-OCT-2012 (Created) 20-NOV-2019 (Last updated, Version 9) |
Name | Katanin_p60_AL2 |
Scope | Eukaryota |
Template | Q8IYT4 (KATL2_HUMAN) |
Triggered by |
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Protein name |
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Gene name |
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Function | Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. |
Catalytic activity | Reaction=n ATP + n H(2)O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=5.6.1.1; |
Subcellular location | Cytoplasm, cytoskeleton. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis. |
Similarity | Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily. |
PROSITE | PS00674; AAA; 1; |
PS50896; LISH; 1; trigger=PRU00126; | |
Pfam | PF00004; AAA; 1; |
PF08513; LisH; 1; |
From: KATL2_HUMAN (Q8IYT4) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND | 294 | 301 | ATP | G-P-P-[GD]-[TLN]-G-K-T |
Size range | 403-603 amino acids |
Related rules | None |
Fusion | None |