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HAMAP rule MF_03025

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General rule information [?]

Accession MF_03025
Dates 9-OCT-2012 (Created)
19-NOV-2022 (Last updated, Version 12)
Name Katanin_p60_AL2
Scope(s) Eukaryota
Template(s) Q8IYT4 (KATL2_HUMAN); [ Recover all ]
Triggered by HAMAP; MF_03025 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier KATL2
Protein name RecName: Full=Katanin p60 ATPase-containing subunit A-like 2;
                 Short=Katanin p60 subunit A-like 2;
AltName: Full=p60 katanin-like 2;
Gene name Name=KATNAL2;

Comments [?]

FUNCTIONSevers microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
CATALYTIC ACTIVITY Reaction=n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=;
SUBCELLULAR LOCATIONCytoplasm, cytoskeleton. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis.
SIMILARITYBelongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008017; Molecular function:microtubule binding
GO:0051013; Biological process:microtubule severing
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

PROSITE PS00674; AAA; 1;
Pfam PF00004; AAA; 1;
Pfam PF08513; LisH; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 294 301 /ligand="ATP"

Additional information [?]

Size range 403-603 amino acids
Related rules None
Fusion Nter: None Cter: None

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