![]() |
|
Annotation rule MF_03033 |
Accession | MF_03033 |
Dates | 14-APR-2009 (Created) 15-FEB-2022 (Last updated, Version 11) |
Name | AGO4 |
Scope | Eukaryota; Vertebrata |
Templates | Q9HCK5 (AGO4_HUMAN); Q8CJF8 (AGO4_MOUSE): [Recover all] |
Triggered by |
Identifier |
|
Protein name |
|
Gene name |
|
Function | Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. |
Subunit | Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B. Interacts with ZFP36. |
Subcellular location | Cytoplasm, P-body. |
Similarity | Belongs to the argonaute family. Ago subfamily. |
PROSITE | PS50821; PAZ; 1; trigger=PRU00142; |
PS50822; PIWI; 1; trigger=PRU00150; | |
Pfam | PF08699; DUF1785; 1; |
PF02170; PAZ; 1; | |
PF02171; Piwi; 1; |
Size range | 794-884 amino acids |
Related rules | None |
Fusion | None |