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HAMAP rule MF_03033

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General rule information [?]

Accession MF_03033
Dates 14-APR-2009 (Created)
15-FEB-2022 (Last updated, Version 11)
Name AGO4
Scope(s) Eukaryota
Template(s) Q9HCK5 (AGO4_HUMAN); Q8CJF8 (AGO4_MOUSE); [ Recover all ]
Triggered by HAMAP; MF_03033 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier AGO4
Protein name RecName: Full=Protein argonaute-4;
AltName: Full=Eukaryotic translation initiation factor 2C 4;
                 Short=eIF-2C 4;
                 Short=eIF2C 4;
Gene name Name=EIF2C4; Synonyms=AGO4;

Comments [?]

FUNCTIONRequired for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.
case <OC:Mammalia>
SUBUNITInteracts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B. Interacts with ZFP36.
end case
SIMILARITYBelongs to the argonaute family. Ago subfamily.

Keywords [?]

Gene Ontology [?]

GO:0035198; Molecular function:miRNA binding
GO:0035278; Biological process:miRNA-mediated gene silencing by inhibition of translation
GO:0016442; Cellular component:RISC complex

Cross-references [?]

PROSITE PS50821; PAZ; 1;
Pfam PF08699; DUF1785; 1;
Pfam PF02170; PAZ; 1;
Pfam PF02171; Piwi; 1;

Features [?]

Additional information [?]

Size range 794-884 amino acids
Related rules None
Fusion Nter: None Cter: None

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