HAMAP rule MF_03033
General rule information
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Accession | MF_03033 |
Dates | 14-APR-2009 (Created)
15-FEB-2022 (Last updated, Version 11) |
Name | AGO4 |
Scope(s) |
Eukaryota Vertebrata |
Template(s) | Q9HCK5 (AGO4_HUMAN); Q8CJF8 (AGO4_MOUSE); [ Recover all ] |
Triggered by |
HAMAP; MF_03033 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | AGO4 |
Protein name | RecName: Full=Protein argonaute-4; Short=Argonaute4; AltName: Full=Eukaryotic translation initiation factor 2C 4; Short=eIF-2C 4; Short=eIF2C 4; |
Gene name | Name=EIF2C4; Synonyms=AGO4; |
Comments
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FUNCTION | Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. |
case <OC:Mammalia> | |
SUBUNIT | Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B. Interacts with ZFP36. |
end case | |
SUBCELLULAR LOCATION | Cytoplasm, P-body. |
SIMILARITY | Belongs to the argonaute family. Ago subfamily. |
Keywords
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Gene Ontology
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GO:0035198; Molecular function:miRNA binding |
GO:0035278; Biological process:miRNA-mediated gene silencing by inhibition of translation |
GO:0016442; Cellular component:RISC complex |
Cross-references
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PROSITE | PS50821; PAZ; 1; |
PROSITE | PS50822; PIWI; 1; |
Pfam | PF08699; DUF1785; 1; |
Pfam | PF02170; PAZ; 1; |
Pfam | PF02171; Piwi; 1; |
Features
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Additional information
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Size range | 794-884 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |