HAMAP rule MF_03033

General rule information [?]

Accession	MF_03033
Dates	14-APR-2009 (Created) 15-FEB-2022 (Last updated, Version 11)

Name

AGO4

Scope

Eukaryota; Vertebrata

Templates

Q9HCK5 (AGO4_HUMAN); Q8CJF8 (AGO4_MOUSE): [Recover all]

Triggered by

HAMAP; MF_03033 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

AGO4

Protein name

RecName:		Full=Protein argonaute-4;
		Short=Argonaute4;
AltName:		Full=Eukaryotic translation initiation factor 2C 4;
		Short=eIF-2C 4;
		Short=eIF2C 4;

Gene name

EIF2C4, AGO4

Comments [?]

Function

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

case <OC:Mammalia>

Subunit

Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B. Interacts with ZFP36.

end case

Subcellular location	Cytoplasm, P-body.
Similarity	Belongs to the argonaute family. Ago subfamily.

Keywords [?]

Cytoplasm
Ribonucleoprotein
RNA-binding
RNA-mediated gene silencing
Translation regulation

Gene Ontology [?]

GO:0035198; Molecular function: miRNA binding.
GO:0035278; Biological process: miRNA-mediated gene silencing by inhibition of translation.
GO:0016442; Cellular component: RISC complex.

Cross-references [?]

PROSITE	PS50821; PAZ; 1; trigger=PRU00142;
	PS50822; PIWI; 1; trigger=PRU00150;
Pfam	PF08699; DUF1785; 1;
	PF02170; PAZ; 1;
	PF02171; Piwi; 1;

Additional information [?]

Size range	794-884 amino acids
Related rules	None
Fusion	None

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