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HAMAP rule MF_03033

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General rule information [?]

Accession MF_03033
Dates 14-APR-2009 (Created)
15-FEB-2022 (Last updated, Version 11)
Name AGO4
Eukaryota; Vertebrata
Templates Q9HCK5 (AGO4_HUMAN); Q8CJF8 (AGO4_MOUSE): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Protein argonaute-4;
AltName: Full=Eukaryotic translation initiation factor 2C 4;
Short=eIF-2C 4;
Short=eIF2C 4;
Gene name

Comments [?]

Function Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.
case <OC:Mammalia>
Subunit Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B. Interacts with ZFP36.
end case
Subcellular location Cytoplasm, P-body.
Similarity Belongs to the argonaute family. Ago subfamily.

Keywords [?]

Gene Ontology [?]

GO:0035198; Molecular function: miRNA binding.
GO:0035278; Biological process: miRNA-mediated gene silencing by inhibition of translation.
GO:0016442; Cellular component: RISC complex.

Cross-references [?]

PROSITE PS50821; PAZ; 1; trigger=PRU00142;
PS50822; PIWI; 1; trigger=PRU00150;
Pfam PF08699; DUF1785; 1;
PF02170; PAZ; 1;
PF02171; Piwi; 1;

Additional information [?]

Size range 794-884 amino acids
Related rules None
Fusion None