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HAMAP rule MF_03039

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General rule information [?]

Accession MF_03039
Dates 20-JUL-2009 (Created)
19-NOV-2022 (Last updated, Version 11)
Name NUBP2
Scope
Eukaryota
Templates Q9Y5Y2 (NUBP2_HUMAN); Q9R061 (NUBP2_MOUSE); P40558 (CFD1_YEAST): [Recover all]
case <OC:Eukaryota>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Fungi>
Identifier
CFD1
else
Identifier
NUBP2
end case
case <OC:Mammalia>
Protein name
RecName: Full=Cytosolic Fe-S cluster assembly factor NUBP2;
AltName: Full=Nucleotide-binding protein 2;
Short=NBP 2;
else case <OC:Vertebrata>
Protein name
RecName: Full=Cytosolic Fe-S cluster assembly factor ;
AltName: Full=Nucleotide-binding protein 2;
Short=NBP 2;
else case <OC:Fungi>
Protein name
RecName: Full=Cytosolic Fe-S cluster assembly factor ;
AltName: Full=Cytosolic Fe-S cluster-deficient protein 1;
else
Protein name
RecName: Full=Cytosolic Fe-S cluster assembly factor NUBP2 homolog;
end case
case <OC:Vertebrata>
Gene name
NUBP2
else case <OC:Fungi>
Gene name
CFD1
end case

Comments [?]

case <OC:Saccharomycetes>
Function Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export.
else case <OC:Fungi>
Function Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The @gn(NBP35)-@gn(CFD1) heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
else
Function Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The @gn(NUBP1)-@gn(NUBP2) heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
end case
case <OC:Fungi>
Cofactor [4Fe-4S] cluster
Note: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of @gn(NBP35) and two labile, bridging clusters between subunits of the @gn(NBP35)-@gn(CFD1) heterotetramer.
else
Cofactor [4Fe-4S] cluster
Note: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of @gn(NUBP1) and two labile, bridging clusters between subunits of the @gn(NUBP1)-@gn(NUBP2) heterotetramer.
end case
case <OC:Mammalia>
Subunit Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.
else case <OC:Fungi>
Subunit Heterotetramer of 2 @gn(NBP35) and 2 @gn(CFD1) chains.
else
Subunit Heterotetramer of 2 @gn(NUBP1) and 2 @gn(NUBP2) chains.
end case
case <OC:Mammalia>
Subcellular location Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Enriched at the centrosomes during mitosis.
else
Subcellular location Cytoplasm.
end case
Similarity Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.

Keywords [?]

case <FTTag:acetyl>
Acetylation
end case
case <FTGroup:1>
4Fe-4S
Iron
Iron-sulfur
Metal-binding
end case
case <FT:1>
ATP-binding
Nucleotide-binding
end case
Cytoplasm
case <OC:Mammalia>
Cytoskeleton
Nucleus
end case

Gene Ontology [?]

GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
GO:0016226; Biological process: iron-sulfur cluster assembly.

Cross-references [?]

PROSITE PS01215; MRP; 1;
Pfam PF10609; ParA; 1;

Features [?]

From: CFD1_YEAST (P40558)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     25     32       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     G-K-G-G-V-G-K-S  
BINDING     201     201       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="ligand shared between dimeric partners     C   1
BINDING     204     204       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="ligand shared between dimeric partners     C   1
case <OC:Mammalia>
From: NUBP2_HUMAN (Q9Y5Y2)
MOD_RES     1     1       N-acetylmethionine   acetyl   M  
end case

Additional information [?]

Size range 255-361 amino acids
Related rules MF_02040 (APBC)
Fusion Nter: None; Cter: MF_03037


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