HAMAP rule MF_03039
General rule information
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| Accession | MF_03039 |
| Dates | 20-JUL-2009 (Created)
19-NOV-2022 (Last updated, Version 11) |
| Name | NUBP2 |
| Scope(s) |
Eukaryota |
| Template(s) | Q9Y5Y2 (NUBP2_HUMAN); Q9R061 (NUBP2_MOUSE); P40558 (CFD1_YEAST); [ Recover all ] |
| Triggered by |
case c? <OC:Eukaryota>
HAMAP; MF_03039 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| case <OC:Fungi> | |
| Identifier | CFD1 |
| else | |
| Identifier | NUBP2 |
| end case | |
| case <OC:Mammalia> | |
| Protein name | RecName: Full=Cytosolic Fe-S cluster assembly factor NUBP2; AltName: Full=Nucleotide-binding protein 2; Short=NBP 2; |
| else case <OC:Vertebrata> | |
| Protein name | RecName: Full=Cytosolic Fe-S cluster assembly factor AltName: Full=Nucleotide-binding protein 2; Short=NBP 2; |
| else case <OC:Fungi> | |
| Protein name | RecName: Full=Cytosolic Fe-S cluster assembly factor AltName: Full=Cytosolic Fe-S cluster-deficient protein 1; |
| else | |
| Protein name | RecName: Full=Cytosolic Fe-S cluster assembly factor NUBP2 homolog; |
| end case | |
| case <OC:Vertebrata> | |
| Gene name | Name=NUBP2; |
| else case <OC:Fungi> | |
| Gene name | Name=CFD1; |
| end case | |
Comments
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| case <OC:Saccharomycetes> | |
| FUNCTION | Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export. |
| else case <OC:Fungi> | |
| FUNCTION | Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The @gn(NBP35)-@gn(CFD1) heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. |
| else | |
| FUNCTION | Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The @gn(NUBP1)-@gn(NUBP2) heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. |
| end case | |
| case <OC:Fungi> | |
| COFACTOR | Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of @gn(NBP35) and two labile, bridging clusters between subunits of the @gn(NBP35)-@gn(CFD1) heterotetramer.; |
| else | |
| COFACTOR | Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of @gn(NUBP1) and two labile, bridging clusters between subunits of the @gn(NUBP1)-@gn(NUBP2) heterotetramer.; |
| end case | |
| case <OC:Mammalia> | |
| SUBUNIT | Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1. |
| else case <OC:Fungi> | |
| SUBUNIT | Heterotetramer of 2 @gn(NBP35) and 2 @gn(CFD1) chains. |
| else | |
| SUBUNIT | Heterotetramer of 2 @gn(NUBP1) and 2 @gn(NUBP2) chains. |
| end case | |
| case <OC:Mammalia> | |
| SUBCELLULAR LOCATION | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Enriched at the centrosomes during mitosis. |
| else | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| end case | |
| SIMILARITY | Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. |
Keywords
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| case <FTTag:acetyl> | |
| Acetylation | |
| end case | |
| case <FTGroup:1> | |
| 4Fe-4S | |
| Iron | |
| Iron-sulfur | |
| Metal-binding | |
| end case | |
| case <FT:1> | |
| ATP-binding | |
| Nucleotide-binding | |
| end case | |
| Cytoplasm | |
| case <OC:Mammalia> | |
| Cytoskeleton | |
| Nucleus | |
| end case | |
Gene Ontology
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| GO:0051539; Molecular function:4 iron, 4 sulfur cluster binding |
| GO:0016226; Biological process:iron-sulfur cluster assembly |
Cross-references
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Features
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| From: CFD1_YEAST (P40558) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 25 | 32 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-K-G-G-V-G-K-S | ||||||||
| BINDING | 201 | 201 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="ligand shared between dimeric partners" |
C | 1 | |||||||
| BINDING | 204 | 204 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="ligand shared between dimeric partners" |
C | 1 | |||||||
| From: NUBP2_HUMAN (Q9Y5Y2) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Mammalia> | ||||||||||||
| MOD_RES | 1 | 1 | /note="N-acetylmethionine" | acetyl | M | |||||||
| end case | ||||||||||||
Additional information
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| Size range | 255-361 amino acids |
| Related rules |
MF_02040 |
| Fusion | Nter: None Cter: MF_03037 |