HAMAP rule MF_03039
General rule information
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Accession | MF_03039 |
Dates | 20-JUL-2009 (Created) 19-NOV-2022 (Last updated, Version 11) |
Name | NUBP2 |
Scope | Eukaryota |
Templates | Q9Y5Y2 (NUBP2_HUMAN); Q9R061 (NUBP2_MOUSE); P40558 (CFD1_YEAST): [Recover all] |
case <OC:Eukaryota>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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case <OC:Fungi>
Identifier |
|
else
Identifier |
|
end case
case <OC:Mammalia>
Protein name |
|
else case <OC:Vertebrata>
Protein name |
|
else case <OC:Fungi>
Protein name |
|
else
Protein name |
|
end case
case <OC:Vertebrata>
Gene name |
|
else case <OC:Fungi>
Gene name |
|
end case
Comments
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case <OC:Saccharomycetes>
Function | Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export. |
else case <OC:Fungi>
Function | Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The @gn(NBP35)-@gn(CFD1) heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. |
else
Function | Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The @gn(NUBP1)-@gn(NUBP2) heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. |
end case
case <OC:Fungi>
Cofactor | [4Fe-4S] cluster Note: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of @gn(NBP35) and two labile, bridging clusters between subunits of the @gn(NBP35)-@gn(CFD1) heterotetramer. |
else
Cofactor | [4Fe-4S] cluster Note: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of @gn(NUBP1) and two labile, bridging clusters between subunits of the @gn(NUBP1)-@gn(NUBP2) heterotetramer. |
end case
case <OC:Mammalia>
Subunit | Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1. |
else case <OC:Fungi>
Subunit | Heterotetramer of 2 @gn(NBP35) and 2 @gn(CFD1) chains. |
else
Subunit | Heterotetramer of 2 @gn(NUBP1) and 2 @gn(NUBP2) chains. |
end case
case <OC:Mammalia>
Subcellular location | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Enriched at the centrosomes during mitosis. |
else
Subcellular location | Cytoplasm. |
end case
Similarity | Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. |
Keywords
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case <FTTag:acetyl>
end case
case <FTGroup:1>
end case
case <FT:1>
end case
case <OC:Mammalia>
end case
Gene Ontology
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GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
GO:0016226; Biological process: iron-sulfur cluster assembly.
GO:0016226; Biological process: iron-sulfur cluster assembly.
Cross-references
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Features
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From: CFD1_YEAST (P40558) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 25 | 32 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | G-K-G-G-V-G-K-S | ||||||||
BINDING | 201 | 201 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="ligand shared between dimeric partners | C | 1 | |||||||
BINDING | 204 | 204 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="ligand shared between dimeric partners | C | 1 |
case <OC:Mammalia>
From: NUBP2_HUMAN (Q9Y5Y2) | ||||||||||||
MOD_RES | 1 | 1 | N-acetylmethionine | acetyl | M |
end case
Additional information
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