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|
Annotation rule MF_03039 |
General rule information
[?]
Accession |
MF_03039 |
Dates |
20-JUL-2009 (Created) 19-NOV-2022 (Last updated, Version 11) |
case <OC:Eukaryota>
end case
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Fungi>
else
end case
case <OC:Mammalia>
Protein name |
RecName:
|
Full=Cytosolic Fe-S cluster assembly factor NUBP2;
|
AltName:
|
Full=Nucleotide-binding protein 2;
|
|
Short=NBP 2;
|
|
else case <OC:Vertebrata>
Protein name |
RecName:
|
Full=Cytosolic Fe-S cluster assembly factor ;
|
AltName:
|
Full=Nucleotide-binding protein 2;
|
|
Short=NBP 2;
|
|
else case <OC:Fungi>
Protein name |
RecName:
|
Full=Cytosolic Fe-S cluster assembly factor ;
|
AltName:
|
Full=Cytosolic Fe-S cluster-deficient protein 1;
|
|
else
Protein name |
RecName:
|
Full=Cytosolic Fe-S cluster assembly factor NUBP2 homolog;
|
|
end case
case <OC:Vertebrata>
else case <OC:Fungi>
end case
case <OC:Saccharomycetes>
Function |
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export. |
else case <OC:Fungi>
Function |
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The @gn(NBP35)-@gn(CFD1) heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. |
else
Function |
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The @gn(NUBP1)-@gn(NUBP2) heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. |
end case
case <OC:Fungi>
Cofactor |
[4Fe-4S] cluster Note: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of @gn(NBP35) and two labile, bridging clusters between subunits of the @gn(NBP35)-@gn(CFD1) heterotetramer. |
else
Cofactor |
[4Fe-4S] cluster Note: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of @gn(NUBP1) and two labile, bridging clusters between subunits of the @gn(NUBP1)-@gn(NUBP2) heterotetramer. |
end case
case <OC:Mammalia>
Subunit |
Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1. |
else case <OC:Fungi>
Subunit |
Heterotetramer of 2 @gn(NBP35) and 2 @gn(CFD1) chains. |
else
Subunit |
Heterotetramer of 2 @gn(NUBP1) and 2 @gn(NUBP2) chains. |
end case
case <OC:Mammalia>
Subcellular location |
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Enriched at the centrosomes during mitosis. |
else
Subcellular location |
Cytoplasm. |
end case
Similarity |
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. |
case <FTTag:acetyl>
end case
case <FTGroup:1>
end case
case <FT:1>
end case
case <OC:Mammalia>
end case
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
GO:0016226; Biological process: iron-sulfur cluster assembly.
From: CFD1_YEAST (P40558) |
Key
|
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From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
BINDING
|
|
25
|
|
32
|
|
/ligand="ATP" /ligand_id="ChEBI:CHEBI:30616
|
|
|
|
G-K-G-G-V-G-K-S
|
|
|
BINDING
|
|
201
|
|
201
|
|
/ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="ligand shared between dimeric partners
|
|
|
|
C
|
|
1
|
BINDING
|
|
204
|
|
204
|
|
/ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="ligand shared between dimeric partners
|
|
|
|
C
|
|
1
|
case <OC:Mammalia>
From: NUBP2_HUMAN (Q9Y5Y2) |
MOD_RES
|
|
1
|
|
1
|
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N-acetylmethionine
|
|
acetyl
|
|
M
|
|
|
end case
Additional information
[?]
Size range |
255-361 amino acids |
Related rules |
MF_02040 (APBC) |
Fusion |
Nter: None; Cter: MF_03037 |