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HAMAP rule MF_03039

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General rule information [?]

Accession MF_03039
Dates 20-JUL-2009 (Created)
19-NOV-2022 (Last updated, Version 11)
Name NUBP2
Scope(s) Eukaryota
Template(s) Q9Y5Y2 (NUBP2_HUMAN); Q9R061 (NUBP2_MOUSE); P40558 (CFD1_YEAST); [ Recover all ]
Triggered by
case c? <OC:Eukaryota>
HAMAP; MF_03039 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Fungi>
Identifier CFD1
else
Identifier NUBP2
end case
case <OC:Mammalia>
Protein name RecName: Full=Cytosolic Fe-S cluster assembly factor NUBP2;
AltName: Full=Nucleotide-binding protein 2;
                 Short=NBP 2;
else case <OC:Vertebrata>
Protein name RecName: Full=Cytosolic Fe-S cluster assembly factor ;
AltName: Full=Nucleotide-binding protein 2;
                 Short=NBP 2;
else case <OC:Fungi>
Protein name RecName: Full=Cytosolic Fe-S cluster assembly factor ;
AltName: Full=Cytosolic Fe-S cluster-deficient protein 1;
else
Protein name RecName: Full=Cytosolic Fe-S cluster assembly factor NUBP2 homolog;
end case
case <OC:Vertebrata>
Gene name Name=NUBP2;
else case <OC:Fungi>
Gene name Name=CFD1;
end case

Comments [?]

case <OC:Saccharomycetes>
FUNCTIONComponent of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export.
else case <OC:Fungi>
FUNCTIONComponent of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The @gn(NBP35)-@gn(CFD1) heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
else
FUNCTIONComponent of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The @gn(NUBP1)-@gn(NUBP2) heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
end case
case <OC:Fungi>
COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of @gn(NBP35) and two labile, bridging clusters between subunits of the @gn(NBP35)-@gn(CFD1) heterotetramer.;
else
COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of @gn(NUBP1) and two labile, bridging clusters between subunits of the @gn(NUBP1)-@gn(NUBP2) heterotetramer.;
end case
case <OC:Mammalia>
SUBUNITHeterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.
else case <OC:Fungi>
SUBUNITHeterotetramer of 2 @gn(NBP35) and 2 @gn(CFD1) chains.
else
SUBUNITHeterotetramer of 2 @gn(NUBP1) and 2 @gn(NUBP2) chains.
end case
case <OC:Mammalia>
SUBCELLULAR LOCATIONNucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Enriched at the centrosomes during mitosis.
else
SUBCELLULAR LOCATIONCytoplasm.
end case
SIMILARITYBelongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.

Keywords [?]

case <FTTag:acetyl>
Acetylation
end case
case <FTGroup:1>
4Fe-4S
Iron
Iron-sulfur
Metal-binding
end case
case <FT:1>
ATP-binding
Nucleotide-binding
end case
Cytoplasm
case <OC:Mammalia>
Cytoskeleton
Nucleus
end case

Gene Ontology [?]

GO:0051539; Molecular function:4 iron, 4 sulfur cluster binding
GO:0016226; Biological process:iron-sulfur cluster assembly

Cross-references [?]

PROSITE PS01215; MRP; 1;
Pfam PF10609; ParA; 1;

Features [?]

From: CFD1_YEAST (P40558)
Key From To Description Tag Condition FTGroup
BINDING 25 32 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
G-K-G-G-V-G-K-S
BINDING 201 201 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_note="ligand shared between dimeric partners"
C 1
BINDING 204 204 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_note="ligand shared between dimeric partners"
C 1
From: NUBP2_HUMAN (Q9Y5Y2)
Key From To Description Tag Condition FTGroup
case <OC:Mammalia>
MOD_RES 1 1 /note="N-acetylmethionine" acetyl M
end case

Additional information [?]

Size range 255-361 amino acids
Related rules MF_02040
Fusion Nter: None Cter: MF_03037



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