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HAMAP rule MF_03041

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General rule information [?]

Accession MF_03041
Dates 3-AUG-2009 (Created)
4-JUN-2021 (Last updated, Version 10)
Name SPDLY
Scope(s) Eukaryota
Vertebrata
Template(s) Q96EA4 (SPDLY_HUMAN); [ Recover all ]
Triggered by HAMAP; MF_03041 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SPDLY
Protein name RecName: Full=Protein Spindly;
AltName: Full=Coiled-coil domain-containing protein 99;
AltName: Full=Spindle apparatus coiled-coil domain-containing protein 1;
Gene name Name=SPDL1; Synonyms=CCDC99;

Comments [?]

case <OC:Mammalia>
FUNCTIONRequired for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.
else
FUNCTIONRequired for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex.
end case
case <OC:Mammalia>
SUBUNITInteracts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.
end case
case <OC:Mammalia>
SUBCELLULAR LOCATIONCytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex.
else
SUBCELLULAR LOCATIONChromosome, centromere, kinetochore.
end case
SIMILARITYBelongs to the Spindly family.

Keywords [?]


Gene Ontology [?]

GO:0043515; Molecular function:kinetochore binding
GO:0034501; Biological process:protein localization to kinetochore
GO:0000940; Cellular component:outer kinetochore

Cross-references [?]

General Coiled_coil; -; 1-unlimited;

Features [?]


Additional information [?]

Size range 590-611 amino acids
Related rules None
Fusion Nter: None Cter: None



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