HAMAP rule MF_03041
General rule information
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| Accession | MF_03041 |
| Dates | 3-AUG-2009 (Created)
4-JUN-2021 (Last updated, Version 10) |
| Name | SPDLY |
| Scope(s) |
Eukaryota Vertebrata |
| Template(s) | Q96EA4 (SPDLY_HUMAN); [ Recover all ] |
| Triggered by |
HAMAP; MF_03041 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | SPDLY |
| Protein name | RecName: Full=Protein Spindly; AltName: Full=Coiled-coil domain-containing protein 99; AltName: Full=Spindle apparatus coiled-coil domain-containing protein 1; |
| Gene name | Name=SPDL1; Synonyms=CCDC99; |
Comments
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| case <OC:Mammalia> | |
| FUNCTION | Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. |
| else | |
| FUNCTION | Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. |
| end case | |
| case <OC:Mammalia> | |
| SUBUNIT | Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect. |
| end case | |
| case <OC:Mammalia> | |
| SUBCELLULAR LOCATION | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex. |
| else | |
| SUBCELLULAR LOCATION | Chromosome, centromere, kinetochore. |
| end case | |
| SIMILARITY | Belongs to the Spindly family. |
Keywords
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| Centromere | |
| Cell cycle | |
| Cell division | |
| Chromosome | |
| Kinetochore | |
| Mitosis | |
| case <OC:Mammalia> | |
| Cytoplasm | |
| Cytoskeleton | |
| Nucleus | |
| end case | |
Gene Ontology
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| GO:0043515; Molecular function:kinetochore binding |
| GO:0034501; Biological process:protein localization to kinetochore |
| GO:0000940; Cellular component:outer kinetochore |
Cross-references
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| General | Coiled_coil; -; 1-unlimited; |
Features
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Additional information
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| Size range | 590-611 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |