Home  |  Contact
Annotation rule MF_03041
Send feedback

General rule information [?]

Accession MF_03041
Dates 3-AUG-2009 (Created)
20-NOV-2019 (Last updated, Version 9)
Name SPDLY
Scope
Eukaryota; Vertebrata
Template Q96EA4 (SPDLY_HUMAN)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SPDLY
Protein name
RecName: Full=Protein Spindly;
AltName: Full=Coiled-coil domain-containing protein 99;
AltName: Full=Spindle apparatus coiled-coil domain-containing protein 1;
Gene name
SPDL1, CCDC99

Comments [?]

case <OC:Mammalia>
Function Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.
else
Function Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex.
end case
case <OC:Mammalia>
Subunit Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.
end case
case <OC:Mammalia>
Subcellular location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex.
else
Subcellular location Chromosome, centromere, kinetochore.
end case
Similarity Belongs to the Spindly family.

Keywords [?]

case <OC:Mammalia>
end case

Gene Ontology [?]

GO:0043515; Molecular function: kinetochore binding.
GO:0034501; Biological process: protein localization to kinetochore.
GO:0000940; Cellular component: condensed chromosome outer kinetochore.

Computed features [?]

General Coiled_coil; -; 1-unlimited; trigger=yes;

Additional information [?]

Size range 590-611 amino acids
Related rules None
Fusion None