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HAMAP rule MF_03043

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General rule information [?]

Accession MF_03043
Dates 11-AUG-2009 (Created)
27-JUL-2023 (Last updated, Version 14)
Name QTRT2
Scope(s) Eukaryota
Template(s) B8ZXI1 (QTRT2_MOUSE); [ Recover all ]
Triggered by HAMAP; MF_03043 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier QTRT2
Protein name RecName: Full=Queuine tRNA-ribosyltransferase accessory subunit 2;
AltName: Full=Queuine tRNA-ribosyltransferase domain-containing protein 1;
case <OC:Vertebrata>
Gene name Name=QTRT2;
else case <OC:Caenorhabditis>
Gene name Name=tgt-2;
end case

Comments [?]

FUNCTIONNon-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
case <FTGroup:1>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
end case
case <OC:Vertebrata>
SUBUNITHeterodimer of a catalytic subunit @gn(QTRT1) and an accessory subunit @gn(QTRT2).
SUBCELLULAR LOCATIONCytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=May associate with the mitochondrion outer membrane.
SUBUNITHeterodimer of a catalytic subunit and an accessory subunit.
end case
SIMILARITYBelongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.

Keywords [?]

case <OC:Vertebrata>
Mitochondrion outer membrane
end case
tRNA processing
case <FTGroup:1>
end case

Gene Ontology [?]

GO:0005737; Cellular component:cytoplasm
case <OCellular component:Vertebrata>
GO:0005741; Cellular component:mitochondrial outer membrane
end case
GO:0008479; Molecular function:tRNA-guanosine(34) queuine transglycosylase activity
GO:0101030; Biological process:tRNA-guanine transglycosylation

Cross-references [?]

Pfam PF01702; TGT; 1;
NCBIfam TIGR00449; tgt_general; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 351 351 /ligand="Zn(2+)"
C 1
BINDING 353 353 /ligand="Zn(2+)"
C 1
BINDING 356 356 /ligand="Zn(2+)"
C 1
BINDING 382 382 /ligand="Zn(2+)"
H 1

Additional information [?]

Size range 369-432 amino acids
Related rules None
Fusion Nter: None Cter: None

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