HAMAP rule MF_03043
General rule information
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| Accession | MF_03043 |
| Dates | 11-AUG-2009 (Created)
27-JUL-2023 (Last updated, Version 14) |
| Name | QTRT2 |
| Scope(s) |
Eukaryota |
| Template(s) | B8ZXI1 (QTRT2_MOUSE); [ Recover all ] |
| Triggered by |
HAMAP; MF_03043 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | QTRT2 |
| Protein name | RecName: Full=Queuine tRNA-ribosyltransferase accessory subunit 2; AltName: Full=Queuine tRNA-ribosyltransferase domain-containing protein 1; |
| case <OC:Vertebrata> | |
| Gene name | Name=QTRT2; |
| else case <OC:Caenorhabditis> | |
| Gene name | Name=tgt-2; |
| end case | |
Comments
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| FUNCTION | Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). |
| case <FTGroup:1> | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| end case | |
| case <OC:Vertebrata> | |
| SUBUNIT | Heterodimer of a catalytic subunit @gn(QTRT1) and an accessory subunit @gn(QTRT2). |
| SUBCELLULAR LOCATION | Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=May associate with the mitochondrion outer membrane. |
| else | |
| SUBUNIT | Heterodimer of a catalytic subunit and an accessory subunit. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| end case | |
| SIMILARITY | Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. |
Keywords
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| Cytoplasm | |
| case <OC:Vertebrata> | |
| Mitochondrion | |
| Mitochondrion outer membrane | |
| Membrane | |
| end case | |
| tRNA processing | |
| case <FTGroup:1> | |
| Metal-binding | |
| Zinc | |
| end case | |
Gene Ontology
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| GO:0005737; Cellular component:cytoplasm | |
| case <OCellular component:Vertebrata> | |
| GO:0005741; Cellular component:mitochondrial outer membrane | |
| end case | |
| GO:0008479; Molecular function:tRNA-guanosine(34) queuine transglycosylase activity | |
| GO:0101030; Biological process:tRNA-guanine transglycosylation | |
Cross-references
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Features
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| From: QTRT2_MOUSE (B8ZXI1) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 351 | 351 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 353 | 353 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 356 | 356 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 382 | 382 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 | |||||||
Additional information
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| Size range | 369-432 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |