HAMAP rule MF_03043

General rule information [?]

Accession	MF_03043
Dates	11-AUG-2009 (Created) 1-JUN-2023 (Last updated, Version 13)

Name

QTRT2

Scope

Eukaryota

Template

B8ZXI1 (QTRT2_MOUSE)

Triggered by

HAMAP; MF_03043 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

QTRT2

Protein name

RecName:		Full=Queuine tRNA-ribosyltransferase accessory subunit 2;
AltName:		Full=Queuine tRNA-ribosyltransferase domain-containing protein 1;

case <OC:Vertebrata>

Gene name

QTRT2

else case <OC:Caenorhabditis>

Gene name

tgt-2

end case

Comments [?]

Function

Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

case <FTGroup:1>

Cofactor

Zn(2+)
Note: Binds 1 zinc ion per subunit.

end case

case <OC:Vertebrata>

Subunit	Heterodimer of a catalytic subunit @gn(QTRT1) and an accessory subunit @gn(QTRT2).
Subcellular location	Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=May associate with the mitochondrion outer membrane.

else