HAMAP rule MF_03043
General rule information
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Accession | MF_03043 |
Dates | 11-AUG-2009 (Created) 1-JUN-2023 (Last updated, Version 13) |
Name | QTRT2 |
Scope | Eukaryota |
Template | B8ZXI1 (QTRT2_MOUSE) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
Protein name |
|
case <OC:Vertebrata>
Gene name |
|
else case <OC:Caenorhabditis>
Gene name |
|
end case
Comments
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Function | Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). |
case <FTGroup:1>
Cofactor | Zn(2+) Note: Binds 1 zinc ion per subunit. |
end case
case <OC:Vertebrata>
Subunit | Heterodimer of a catalytic subunit @gn(QTRT1) and an accessory subunit @gn(QTRT2). |
Subcellular location | Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=May associate with the mitochondrion outer membrane. |
else
Subunit | Heterodimer of a catalytic subunit and an accessory subunit. |
Subcellular location | Cytoplasm. |
end case
Similarity | Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. |
Keywords
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case <OC:Vertebrata>
end case
case <FTGroup:1>
end case
Gene Ontology
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GO:0005737; Cellular component: cytoplasm.
case <OC:Vertebrata>
GO:0005741; Cellular component: mitochondrial outer membrane.
end case
GO:0008479; Molecular function: queuine tRNA-ribosyltransferase activity.
GO:0101030; Biological process: tRNA-guanine transglycosylation.
GO:0101030; Biological process: tRNA-guanine transglycosylation.
Cross-references
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Features
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From: QTRT2_MOUSE (B8ZXI1) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 351 | 351 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 1 | |||||||
BINDING | 353 | 353 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 1 | |||||||
BINDING | 356 | 356 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 1 | |||||||
BINDING | 382 | 382 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | H | 1 |
Additional information
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Size range | 369-432 amino acids |
Related rules | None |
Fusion | None |