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Annotation rule MF_03043
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General rule information [?]

Accession MF_03043
Dates 11-AUG-2009 (Created)
20-NOV-2019 (Last updated, Version 10)
Name QTRT2
Scope
Eukaryota
Template B8ZXI1 (QTRT2_MOUSE)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
QTRT2
Protein name
RecName: Full=Queuine tRNA-ribosyltransferase accessory subunit 2;
AltName: Full=Queuine tRNA-ribosyltransferase domain-containing protein 1;
case <OC:Vertebrata>
Gene name
QTRT2
else case <OC:Caenorhabditis>
Gene name
tgt-2
end case

Comments [?]

Function Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
end case
case <OC:Vertebrata>
Subunit Heterodimer of a catalytic subunit @gn(QTRT1) and an accessory subunit @gn(QTRT2).
Subcellular location Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=May associate with the mitochondrion outer membrane.
else
Subunit Heterodimer of a catalytic subunit and an accessory subunit.
Subcellular location Cytoplasm.
end case
Similarity Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.

Keywords [?]

case <OC:Vertebrata>
end case
case <FTGroup:1>
end case

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
case <OC:Vertebrata>
GO:0005741; Cellular component: mitochondrial outer membrane.
end case
GO:0008479; Molecular function: queuine tRNA-ribosyltransferase activity.
GO:0101030; Biological process: tRNA-guanine transglycosylation.

Cross-references [?]

Pfam PF01702; TGT; 1;
TIGRFAMs TIGR00449; tgt_general; 1;

Features [?]

From: QTRT2_MOUSE (B8ZXI1)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     351     351       Zinc     C   1
METAL     353     353       Zinc     C   1
METAL     356     356       Zinc     C   1
METAL     382     382       Zinc; via pros nitrogen     H   1

Additional information [?]

Size range 369-432 amino acids
Related rules None
Fusion None