HAMAP rule MF_03044
General rule information
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Accession | MF_03044 |
Dates | 26-JUN-2013 (Created) 19-NOV-2022 (Last updated, Version 12) |
Name | BMT2 |
Scope | Eukaryota |
Templates | P38278 (BMT2_YEAST); Q1RMZ1 (SAMTR_HUMAN); Q9W138 (SAMTR_DROME): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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case <OC:Saccharomyces>
Identifier |
|
Protein name |
|
else case <OC:Fungi>
Identifier |
|
Protein name |
|
else case <OC:Metazoa>
Identifier |
|
Protein name |
|
else
Identifier |
|
Protein name |
|
end case
case <OC:Saccharomycotina>
Gene name |
|
else case <OC:Vertebrata>
Gene name |
|
end case
Comments
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case <OC:Saccharomyces>
Function | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine 2142 in 25S rRNA. N(1)-methyladenine(2142) in 25S rRNA is present in helix 65, a region that accounts for most of the intersubunit surface of the large subunit. |
Catalytic activity | RHEA:43784: adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine
EC 2.1.1.286 |
else case <OC:Fungi>
Function | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA. |
else case <OC:Vertebrata>
Function | S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase. |
Subunit | Interacts with the GATOR1 complex; interaction is disrupted when @gn(BMT2/SAMTOR) binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when @gn(BMT2/SAMTOR) binds S-adenosyl-L-methionine. |
else case <OC:Metazoa>
Function | S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase. |
else
Function | Probable S-adenosyl-L-methionine-dependent methyltransferase. |
end case
case <OC:Fungi>
Subcellular location | Nucleus, nucleolus. |
end case
Similarity | Belongs to the BMT2 family. |
Keywords
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case <OC:Fungi>
end case
Gene Ontology
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case <OC:Fungi>
GO:0005730; Cellular component: nucleolus.
GO:0016433; Molecular function: rRNA (adenine) methyltransferase activity.
GO:0016433; Molecular function: rRNA (adenine) methyltransferase activity.
else
GO:0008168; Molecular function: methyltransferase activity.
end case
Cross-references
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Pfam | PF11968; DUF3321; 1; |
Features
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From: SAMTR_HUMAN (Q1RMZ1) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 172 | 172 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | G | ||||||||
BINDING | 190 | 190 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | D |
Additional information
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Size range | 270-672 amino acids |
Related rules | None |
Fusion | None |