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HAMAP rule MF_03044

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General rule information [?]

Accession MF_03044
Dates 26-JUN-2013 (Created)
19-NOV-2022 (Last updated, Version 12)
Name BMT2
Scope
Eukaryota
Templates P38278 (BMT2_YEAST); Q1RMZ1 (SAMTR_HUMAN); Q9W138 (SAMTR_DROME): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Saccharomyces>
Identifier
BMT2
Protein name
RecName: Full=25S rRNA (adenine(2142)-N(1))-methyltransferase;
EC 2.1.1.286;
AltName: Full=Base MethylTransferase of 25S RNA;
else case <OC:Fungi>
Identifier
BMT2
Protein name
RecName: Full=25S rRNA adenine-N(1) methyltransferase;
EC 2.1.1.-;
else case <OC:Metazoa>
Identifier
SAMTR
Protein name
RecName: Full=S-adenosylmethionine sensor upstream of mTORC1;
AltName: Full=Probable methyltransferase BMT2 homolog;
EC 2.1.1.-;
else
Identifier
BMT2
Protein name
RecName: Full=Probable methyltransferase BMT2 homolog;
EC 2.1.1.-;
end case
case <OC:Saccharomycotina>
Gene name
BMT2
else case <OC:Vertebrata>
Gene name
BMT2, SAMTOR
end case

Comments [?]

case <OC:Saccharomyces>
Function S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine 2142 in 25S rRNA. N(1)-methyladenine(2142) in 25S rRNA is present in helix 65, a region that accounts for most of the intersubunit surface of the large subunit.
Catalytic activity RHEA:43784: adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine
EC 2.1.1.286
else case <OC:Fungi>
Function S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.
else case <OC:Vertebrata>
Function S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.
Subunit Interacts with the GATOR1 complex; interaction is disrupted when @gn(BMT2/SAMTOR) binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when @gn(BMT2/SAMTOR) binds S-adenosyl-L-methionine.
else case <OC:Metazoa>
Function S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.
else
Function Probable S-adenosyl-L-methionine-dependent methyltransferase.
end case
case <OC:Fungi>
Subcellular location Nucleus, nucleolus.
end case
Similarity Belongs to the BMT2 family.

Keywords [?]

case <OC:Fungi>
Nucleus
end case
Methyltransferase
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

case <OC:Fungi>
GO:0005730; Cellular component: nucleolus.
GO:0016433; Molecular function: rRNA (adenine) methyltransferase activity.
else
GO:0008168; Molecular function: methyltransferase activity.
end case

Cross-references [?]

Pfam PF11968; DUF3321; 1;

Features [?]

From: SAMTR_HUMAN (Q1RMZ1)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     172     172       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     G  
BINDING     190     190       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     D  

Additional information [?]

Size range 270-672 amino acids
Related rules None
Fusion None


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