HAMAP rule MF_03044
General rule information
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Accession | MF_03044 |
Dates | 26-JUN-2013 (Created)
19-NOV-2022 (Last updated, Version 12) |
Name | BMT2 |
Scope(s) |
Eukaryota |
Template(s) | P38278 (BMT2_YEAST); Q1RMZ1 (SAMTR_HUMAN); Q9W138 (SAMTR_DROME); [ Recover all ] |
Triggered by |
HAMAP; MF_03044 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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case <OC:Saccharomyces> | |
Identifier | BMT2 |
Protein name | RecName: Full=25S rRNA (adenine(2142)-N(1))-methyltransferase; EC=2.1.1.286; AltName: Full=Base MethylTransferase of 25S RNA; |
else case <OC:Fungi> | |
Identifier | BMT2 |
Protein name | RecName: Full=25S rRNA adenine-N(1) methyltransferase; EC=2.1.1.-; |
else case <OC:Metazoa> | |
Identifier | SAMTR |
Protein name | RecName: Full=S-adenosylmethionine sensor upstream of mTORC1; AltName: Full=Probable methyltransferase BMT2 homolog; EC=2.1.1.-; |
else | |
Identifier | BMT2 |
Protein name | RecName: Full=Probable methyltransferase BMT2 homolog; EC=2.1.1.-; |
end case | |
case <OC:Saccharomycotina> | |
Gene name | Name=BMT2; |
else case <OC:Vertebrata> | |
Gene name | Name=BMT2; Synonyms=SAMTOR; |
end case |
Comments
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case <OC:Saccharomyces> | |
FUNCTION | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine 2142 in 25S rRNA. N(1)-methyladenine(2142) in 25S rRNA is present in helix 65, a region that accounts for most of the intersubunit surface of the large subunit. |
CATALYTIC ACTIVITY | Reaction=adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:43784, Rhea:RHEA-COMP:10691, Rhea:RHEA-COMP:10692, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74491; EC=2.1.1.286; |
else case <OC:Fungi> | |
FUNCTION | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA. |
else case <OC:Vertebrata> | |
FUNCTION | S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L- methionine-dependent methyltransferase. |
SUBUNIT | Interacts with the GATOR1 complex; interaction is disrupted when @gn(BMT2/SAMTOR) binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when @gn(BMT2/SAMTOR) binds S-adenosyl-L-methionine. |
else case <OC:Metazoa> | |
FUNCTION | S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling. Acts as a sensor of S-adenosyl-L- methionine to signal methionine sufficiency to mTORC1. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase. |
else | |
FUNCTION | Probable S-adenosyl-L-methionine-dependent methyltransferase. |
end case | |
case <OC:Fungi> | |
SUBCELLULAR LOCATION | Nucleus, nucleolus. |
end case | |
SIMILARITY | Belongs to the BMT2 family. |
Keywords
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case <OC:Fungi> | |
Nucleus | |
end case | |
Methyltransferase | |
S-adenosyl-L-methionine | |
Transferase |
Gene Ontology
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case <OCellular component:Fungi> | |
GO:0005730; Cellular component:nucleolus | |
GO:0016433; Molecular function:rRNA (adenine) methyltransferase activity | |
else; https://www.ebi.ac.uk/QuickGO/term/else | |
GO:0008168; Molecular function:methyltransferase activity | |
end case |
Cross-references
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Pfam | PF11968; DUF3321; 1; |
Features
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From: SAMTR_HUMAN (Q1RMZ1) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 172 | 172 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
G | ||||||||
BINDING | 190 | 190 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D |
Additional information
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Size range | 270-672 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |