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Annotation rule MF_03044 |
General rule information
[?]
Accession |
MF_03044 |
Dates |
26-JUN-2013 (Created) 20-NOV-2019 (Last updated, Version 10) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Saccharomyces>
Protein name |
RecName:
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Full=25S rRNA (adenine(2142)-N(1))-methyltransferase;
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EC 2.1.1.286;
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AltName:
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Full=Base MethylTransferase of 25S RNA;
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else case <OC:Fungi>
Protein name |
RecName:
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Full=25S rRNA adenine-N(1) methyltransferase;
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EC 2.1.1.-;
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else case <OC:Metazoa>
Protein name |
RecName:
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Full=S-adenosylmethionine sensor upstream of mTORC1;
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AltName:
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Full=Probable methyltransferase BMT2 homolog;
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EC 2.1.1.-;
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else
Protein name |
RecName:
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Full=Probable methyltransferase BMT2 homolog;
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EC 2.1.1.-;
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end case
case <OC:Saccharomycotina>
else case <OC:Vertebrata>
end case
case <OC:Saccharomyces>
Function |
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine 2142 in 25S rRNA. N(1)-methyladenine(2142) in 25S rRNA is present in helix 65, a region that accounts for most of the intersubunit surface of the large subunit. |
Catalytic activity |
RHEA:43784: adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine
EC 2.1.1.286
|
else case <OC:Fungi>
Function |
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA. |
else case <OC:Vertebrata>
Function |
S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase. |
Subunit |
Interacts with the GATOR1 complex; interaction is disrupted when @gn(BMT2/SAMTOR) binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when @gn(BMT2/SAMTOR) binds S-adenosyl-L-methionine. |
else case <OC:Metazoa>
Function |
S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase. |
else
Function |
Probable S-adenosyl-L-methionine-dependent methyltransferase. |
end case
case <OC:Fungi>
Subcellular location |
Nucleus, nucleolus. |
end case
Similarity |
Belongs to the BMT2 family. |
case <OC:Fungi>
end case
case <OC:Fungi>
GO:0005730; Cellular component: nucleolus.
GO:0016433; Molecular function: rRNA (adenine) methyltransferase activity.
else
GO:0008168; Molecular function: methyltransferase activity.
end case
From: SAMTR_HUMAN (Q1RMZ1) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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BINDING
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172
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172
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S-adenosyl-L-methionine
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G
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BINDING
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190
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190
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S-adenosyl-L-methionine
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D
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Additional information
[?]
Size range |
270-672 amino acids |
Related rules |
None |
Fusion |
None |