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Annotation rule MF_03045
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General rule information [?]

Accession MF_03045
Dates 26-JUN-2013 (Created)
20-NOV-2019 (Last updated, Version 9)
Name DIS3L2
Scope
Eukaryota
Templates Q8IYB7 (DI3L2_HUMAN); Q8CI75 (DI3L2_MOUSE); P0DM58 (DI3L2_ARATH); O14040 (DI3L2_SCHPO): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
DI3L2
Protein name
RecName: Full=DIS3-like exonuclease 2;
EC 3.1.13.-;
case <OC:Mammalia>
Gene name
DIS3L2
else case <OC:Vertebrata>
Gene name
dis3l2
end case

Comments [?]

case <OC:Mammalia>
Function 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.
else case <OC:Vertebrata>
Function 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation.
else
Function 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.
end case
Cofactor Mg(2+)
Mn(2+)
Subcellular location Cytoplasm. Cytoplasm, P-body.
case <OC:Vertebrata>
Domain Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site.
end case
Similarity Belongs to the RNR ribonuclease family. DIS3L2 subfamily.

Keywords [?]

case <OC:Vertebrata>
end case

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0000932; Cellular component: P-body.
GO:0000175; Molecular function: 3'-5'-exoribonuclease activity.
GO:0000291; Biological process: nuclear-transcribed mRNA catabolic process, exonucleolytic.
GO:1990074; Biological process: polyuridylation-dependent mRNA catabolic process.
case <OC:Vertebrata>
GO:0010587; Biological process: miRNA catabolic process.
end case

Cross-references [?]

PROSITE PS01175; RIBONUCLEASE_II; 1;
Pfam PF00773; RNB; 1;

Features [?]

From: DI3L2_MOUSE (Q8CI75)
Key     From     To       Description   Tag   Condition   FTGroup
SITE     389     389       Important for catalytic activity     D  
METAL     381     381       Magnesium     D  
METAL     390     390       Magnesium     D  

Additional information [?]

Size range 811-1426 amino acids
Related rules None
Fusion None