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| Annotation rule MF_03045 |
General rule information
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| Accession | MF_03045 |
| Dates | 26-JUN-2013 (Created) 20-NOV-2019 (Last updated, Version 9) |
| Name | DIS3L2 |
| Scope | Eukaryota |
| Templates | Q8IYB7 (DI3L2_HUMAN); Q8CI75 (DI3L2_MOUSE); P0DM58 (DI3L2_ARATH); O14040 (DI3L2_SCHPO): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
|
| Protein name |
|
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case <OC:Mammalia>
| Gene name |
|
else case <OC:Vertebrata>
| Gene name |
|
end case
Comments
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case <OC:Mammalia>
| Function | 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. |
else case <OC:Vertebrata>
| Function | 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. |
else
| Function | 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. |
end case
case <OC:Vertebrata>
| Domain | Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site. |
end case
| Similarity | Belongs to the RNR ribonuclease family. DIS3L2 subfamily. |
Keywords
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case <OC:Vertebrata>
end case
Gene Ontology
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GO:0005737; Cellular component: cytoplasm.
GO:0000932; Cellular component: P-body.
GO:0000175; Molecular function: 3'-5'-exoribonuclease activity.
GO:0000291; Biological process: nuclear-transcribed mRNA catabolic process, exonucleolytic.
GO:1990074; Biological process: polyuridylation-dependent mRNA catabolic process.
GO:0000932; Cellular component: P-body.
GO:0000175; Molecular function: 3'-5'-exoribonuclease activity.
GO:0000291; Biological process: nuclear-transcribed mRNA catabolic process, exonucleolytic.
GO:1990074; Biological process: polyuridylation-dependent mRNA catabolic process.
case <OC:Vertebrata>
GO:0010587; Biological process: miRNA catabolic process.
end case
Cross-references
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Features
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| From: DI3L2_MOUSE (Q8CI75) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| SITE | 389 | 389 | Important for catalytic activity | D | ||||||||
| METAL | 381 | 381 | Magnesium | D | ||||||||
| METAL | 390 | 390 | Magnesium | D | ||||||||
Additional information
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| Size range | 811-1426 amino acids |
| Related rules | None |
| Fusion | None |