HAMAP rule MF_03045
General rule information
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| Accession | MF_03045 |
| Dates | 26-JUN-2013 (Created)
7-FEB-2023 (Last updated, Version 12) |
| Name | DIS3L2 |
| Scope(s) |
Eukaryota |
| Template(s) | Q8IYB7 (DI3L2_HUMAN); Q8CI75 (DI3L2_MOUSE); P0DM58 (DI3L2_ARATH); O14040 (DI3L2_SCHPO); [ Recover all ] |
| Triggered by |
HAMAP; MF_03045 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DI3L2 |
| Protein name | RecName: Full=DIS3-like exonuclease 2; EC=3.1.13.-; |
| case <OC:Mammalia> | |
| Gene name | Name=DIS3L2; |
| else case <OC:Vertebrata> | |
| Gene name | Name=dis3l2; |
| end case | |
Comments
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| case <OC:Mammalia> | |
| FUNCTION | 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. |
| else case <OC:Vertebrata> | |
| FUNCTION | 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. |
| else | |
| FUNCTION | 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. |
| end case | |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; |
| SUBCELLULAR LOCATION | Cytoplasm. Cytoplasm, P-body. |
| case <OC:Vertebrata> | |
| DOMAIN | Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site. |
| end case | |
| SIMILARITY | Belongs to the RNR ribonuclease family. DIS3L2 subfamily. |
Keywords
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| Cytoplasm | |
| Exonuclease | |
| Hydrolase | |
| Magnesium | |
| Manganese | |
| Metal-binding | |
| Nuclease | |
| RNA-binding | |
| case <OC:Vertebrata> | |
| Cell cycle | |
| Cell division | |
| Mitosis | |
| end case | |
Gene Ontology
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| GO:0005737; Cellular component:cytoplasm | |
| GO:0000932; Cellular component:P-body | |
| GO:0000175; Molecular function:3'-5'-RNA exonuclease activity | |
| GO:0000291; Biological process:nuclear-transcribed mRNA catabolic process, exonucleolytic | |
| GO:1990074; Biological process:polyuridylation-dependent mRNA catabolic process | |
| case <OCellular component:Vertebrata> | |
| GO:0010587; Biological process:miRNA catabolic process | |
| end case | |
Cross-references
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Features
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| From: DI3L2_MOUSE (Q8CI75) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| SITE | 389 | 389 | /note="Important for catalytic activity" | D | ||||||||
| BINDING | 381 | 381 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
| BINDING | 390 | 390 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
Additional information
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| Size range | 811-1426 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |