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HAMAP rule MF_03045

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General rule information [?]

Accession MF_03045
Dates 26-JUN-2013 (Created)
7-FEB-2023 (Last updated, Version 12)
Name DIS3L2
Scope(s) Eukaryota
Template(s) Q8IYB7 (DI3L2_HUMAN); Q8CI75 (DI3L2_MOUSE); P0DM58 (DI3L2_ARATH); O14040 (DI3L2_SCHPO); [ Recover all ]
Triggered by HAMAP; MF_03045 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DI3L2
Protein name RecName: Full=DIS3-like exonuclease 2;
                 EC=3.1.13.-;
case <OC:Mammalia>
Gene name Name=DIS3L2;
else case <OC:Vertebrata>
Gene name Name=dis3l2;
end case

Comments [?]

case <OC:Mammalia>
FUNCTION3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.
else case <OC:Vertebrata>
FUNCTION3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation.
else
FUNCTION3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.
end case
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
SUBCELLULAR LOCATIONCytoplasm. Cytoplasm, P-body.
case <OC:Vertebrata>
DOMAINSpecifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site.
end case
SIMILARITYBelongs to the RNR ribonuclease family. DIS3L2 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0005737; Cellular component:cytoplasm
GO:0000932; Cellular component:P-body
GO:0000175; Molecular function:3'-5'-RNA exonuclease activity
GO:0000291; Biological process:nuclear-transcribed mRNA catabolic process, exonucleolytic
GO:1990074; Biological process:polyuridylation-dependent mRNA catabolic process
case <OCellular component:Vertebrata>
GO:0010587; Biological process:miRNA catabolic process
end case

Cross-references [?]

PROSITE PS01175; RIBONUCLEASE_II; 1;
Pfam PF00773; RNB; 1;

Features [?]

From: DI3L2_MOUSE (Q8CI75)
Key From To Description Tag Condition FTGroup
SITE 389 389 /note="Important for catalytic activity" D
BINDING 381 381 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
D
BINDING 390 390 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
D

Additional information [?]

Size range 811-1426 amino acids
Related rules None
Fusion Nter: None Cter: None



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