 |
|
Annotation rule MF_03045 |
General rule information
[?]
Accession |
MF_03045 |
Dates |
26-JUN-2013 (Created) 20-NOV-2019 (Last updated, Version 9) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Mammalia>
else case <OC:Vertebrata>
end case
case <OC:Mammalia>
Function |
3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. |
else case <OC:Vertebrata>
Function |
3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. |
else
Function |
3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. |
end case
Cofactor |
Mg(2+) Mn(2+) |
Subcellular location |
Cytoplasm. Cytoplasm, P-body. |
case <OC:Vertebrata>
Domain |
Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site. |
end case
Similarity |
Belongs to the RNR ribonuclease family. DIS3L2 subfamily. |
case <OC:Vertebrata>
end case
GO:0005737; Cellular component: cytoplasm.
GO:0000932; Cellular component: P-body.
GO:0000175; Molecular function: 3'-5'-exoribonuclease activity.
GO:0000291; Biological process: nuclear-transcribed mRNA catabolic process, exonucleolytic.
GO:1990074; Biological process: polyuridylation-dependent mRNA catabolic process.
case <OC:Vertebrata>
GO:0010587; Biological process: miRNA catabolic process.
end case
From: DI3L2_MOUSE (Q8CI75) |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
SITE
|
|
389
|
|
389
|
|
Important for catalytic activity
|
|
|
|
D
|
|
|
METAL
|
|
381
|
|
381
|
|
Magnesium
|
|
|
|
D
|
|
|
METAL
|
|
390
|
|
390
|
|
Magnesium
|
|
|
|
D
|
|
|
Additional information
[?]
Size range |
811-1426 amino acids |
Related rules |
None |
Fusion |
None |