HAMAP logo

HAMAP rule MF_03047

Send feedback

General rule information [?]

Accession MF_03047
Dates 26-FEB-2009 (Created)
29-JUN-2022 (Last updated, Version 13)
Name Sgf11
Scope
Eukaryota
Templates Q03067 (SGF11_YEAST); Q14CW9 (AT7L3_HUMAN); Q9VVR6 (SGF11_DROME): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Vertebrata>
Identifier
AT7L3
Protein name
RecName: Full=Ataxin-7-like protein 3;
AltName: Full=SAGA-associated factor 11 homolog;
else case <OC:Fungi>
Identifier
SGF11
Protein name
RecName: Full=SAGA-associated factor 11;
else
Identifier
SGF11
Protein name
RecName: Full=SAGA-associated factor 11 homolog;
end case
case <OC:Vertebrata>
Gene name
ATXN7L3
else case <OC:Fungi>
Gene name
SGF11
else case <OC:Insecta>
Gene name
Sgf11
end case

Comments [?]

case <OC:Mammalia>
Function Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as @gn(MYC), where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B.
Subunit Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ENY2 and USP22.
Domain The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of @gn(USP22) forms the 'catalytic lobe' of the SAGA deubiquitination module.
else case <OC:Drosophilidae>
Function Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Binds independently on SAGA to promoters in an RNA-dependent manner. Binds to mRNA and is essential for total mRNA export from the nucleus. Required to counteract heterochromatin silencing. Controls the development of neuronal connectivity in visual system by being required for accurate axon targeting in the optic lobe. Required for expression of ecdysone-induced genes such as br/broad.
Subunit Component of some SAGA transcription coactivator-HAT complexes, at least composed of Ada2b, not/nonstop, Pcaf/Gcn5, Sgf11 and Spt3. Within the SAGA complex, Sgf11, e(y)2, and not/nonstop form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with not/nonstop. Interacts with the AMEX complex component xmas-2. Interacts with Cbp80; important for promoter recruitment of Sgf11 that is not associated with the DUB module.
Domain The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of not/nonstop forms the 'catalytic lobe' of the SAGA deubiquitination module.
else case <OC:Fungi>
Function Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). Involved in transcriptional regulation of a subset of SAGA-regulated genes. Within the SAGA complex, participates in a subcomplex, that specifically deubiquitinates histones H2B.
Subunit Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, @gn(SUS1), @gn(SGF11), @gn(SGF73) and @gn(UBP8) form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with @gn(SGF73), @gn(SUS1) and @gn(UBP8).
Domain The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of @gn(UBP8) forms the 'catalytic lobe' of the SAGA deubiquitination module.
else
Function Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.
Subunit Component of some SAGA transcription coactivator-HAT complexes. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).
Domain The C-terminal SGF11-type zinc-finger domain forms part of the 'catalytic lobe' of the SAGA deubiquitination module.
end case
case <OC:Drosophilidae>
Subcellular location Nucleus, nucleoplasm. Cytoplasm. Note=Localizes to nuclear periphery, in contact with the nuclear pore complex (NPC).
else
Subcellular location Nucleus.
end case
Domain The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.
Similarity Belongs to the SGF11 family.

Keywords [?]

Activator
Chromatin regulator
Metal-binding
Nucleus
Transcription
Transcription regulation
Zinc
Zinc-finger
case <OC:Drosophilidae>
Cytoplasm
mRNA transport
Transport
end case

Gene Ontology [?]

case <OC:Mammalia> or <OC:Drosophilidae>
GO:0030374; Molecular function: nuclear receptor coactivator activity.
end case
case <OC:Drosophilidae>
GO:0005737; Cellular component: cytoplasm.
GO:0006406; Biological process: mRNA export from nucleus.
GO:0005643; Cellular component: nuclear pore.
end case
GO:0003713; Molecular function: transcription coactivator activity.
GO:0008270; Molecular function: zinc ion binding.
GO:0045893; Biological process: positive regulation of DNA-templated transcription.
GO:0016578; Biological process: histone deubiquitination.
GO:0000124; Cellular component: SAGA complex.
GO:0071819; Cellular component: DUBm complex.
GO:0005634; Cellular component: nucleus.

Cross-references [?]

Pfam PF08313; SCA7; 0-1;
PF08209; Sgf11; 1;
case <OC:Vertebrata>
PROSITE PS51505; SCA7; 1; trigger=PRU00838;
end case

Features [?]

From: SGF11_YEAST (Q03067)
Key     From     To       Description   Tag   Condition   FTGroup
ZN_FING     71     92       SGF11-type     [YCIFL]-x-C-x(2)-C-x(11)-H-x(3)-C  

Additional information [?]

Size range 90-374 amino acids
Related rules None
Fusion None


View rule in raw text format (no links)