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Annotation rule MF_03050
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General rule information [?]

Accession MF_03050
Dates 6-MAR-2009 (Created)
20-NOV-2019 (Last updated, Version 10)
Name MOCOS
Scope
Eukaryota
Templates Q96EN8 (MOCOS_HUMAN); Q9N0E7 (MOCOS_BOVIN); Q9VRA2 (MOCOS_DROME); Q9C5X8 (MOCOS_ARATH); Q9UV64 (MOCOS_EMENI): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MOCOS
Protein name
RecName: Full=Molybdenum cofactor sulfurase;
Short=MCS;
Short=MOS;
Short=MoCo sulfurase;
EC 2.8.1.9;
AltName: Full=Molybdenum cofactor sulfurtransferase;
case <OC:Insecta>
Protein name
Full=Protein maroon-like;
Short=Ma-l;
end case
case <OC:Vertebrata>
Gene name
MOCOS
end case
case <OC:Insecta>
Gene name
mal
end case
case <OC:Pezizomycotina>
Gene name
hxB
end case

Comments [?]

Function Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.
Catalytic activity RHEA:42636: AH2 + L-cysteine + Mo-molybdopterin = A + H2O + L-alanine + thio-Mo-molybdopterin
EC 2.8.1.9
Cofactor pyridoxal 5'-phosphate
Similarity Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.

Keywords [?]


Gene Ontology [?]

GO:0016829; Molecular function: lyase activity.
GO:0008265; Molecular function: Mo-molybdopterin cofactor sulfurase activity.
GO:0030151; Molecular function: molybdenum ion binding.
GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0006777; Biological process: Mo-molybdopterin cofactor biosynthetic process.

Cross-references [?]

PROSITE PS00595; AA_TRANSFER_CLASS_5; 1;
PS51340; MOSC; 1; trigger=PRU00670;
Pfam PF00266; Aminotran_5; 1;
PF03473; MOSC; 1;
PF03476; MOSC_N; 1;

Features [?]

From: MOCOS_HUMAN (Q96EN8)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     424     424             C  
MOD_RES     264     264       N6-(pyridoxal phosphate)lysine     K  

Additional information [?]

Size range 707-1007 amino acids
Related rules None
Fusion None