Due to maintenance work, this service will be unavailable from
Mon Nov 11 17:30 until
Tue Nov 12 09:00
CET.
Apologies for the inconvenience.
HAMAP rule MF_03050
General rule information
[?]
| Accession | MF_03050 |
| Dates | 6-MAR-2009 (Created)
20-NOV-2019 (Last updated, Version 10) |
| Name | MOCOS |
| Scope(s) |
Eukaryota |
| Template(s) | Q96EN8 (MOCOS_HUMAN); Q9N0E7 (MOCOS_BOVIN); Q9VRA2 (MOCOS_DROME); Q9C5X8 (MOCOS_ARATH); Q9UV64 (MOCOS_EMENI); [ Recover all ] |
| Triggered by |
HAMAP; MF_03050 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | MOCOS |
| Protein name | RecName: Full=Molybdenum cofactor sulfurase; Short=MCS; Short=MOS; Short=MoCo sulfurase; EC=2.8.1.9; AltName: Full=Molybdenum cofactor sulfurtransferase; |
| case <OC:Insecta> | |
| Protein name | + AltName: Full=Protein maroon-like; Short=Ma-l; |
| end case | |
| case <OC:Vertebrata> | |
| Gene name | Name=MOCOS; |
| end case | |
| case <OC:Insecta> | |
| Gene name | Name=mal; |
| end case | |
| case <OC:Pezizomycotina> | |
| Gene name | Name=hxB; |
| end case | |
Comments
[?]
| FUNCTION | Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. |
| CATALYTIC ACTIVITY | Reaction=AH2 + L-cysteine + Mo-molybdopterin = A + H2O + L-alanine + thio-Mo-molybdopterin; Xref=Rhea:RHEA:42636, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:35235, ChEBI:CHEBI:57972, ChEBI:CHEBI:71302, ChEBI:CHEBI:82685; EC=2.8.1.9; |
| COFACTOR | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; |
| SIMILARITY | Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily. |
Keywords
[?]
Gene Ontology
[?]
| GO:0016829; Molecular function:lyase activity |
| GO:0008265; Molecular function:Mo-molybdopterin cofactor sulfurase activity |
| GO:0030151; Molecular function:molybdenum ion binding |
| GO:0030170; Molecular function:pyridoxal phosphate binding |
| GO:0006777; Biological process:Mo-molybdopterin cofactor biosynthetic process |
Cross-references
[?]
| PROSITE | PS00595; AA_TRANSFER_CLASS_5; 1; |
| PROSITE | PS51340; MOSC; 1; |
| Pfam | PF00266; Aminotran_5; 1; |
| Pfam | PF03473; MOSC; 1; |
| Pfam | PF03476; MOSC_N; 1; |
Features
[?]
| From: MOCOS_HUMAN (Q96EN8) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 424 | 424 | C | |||||||||
| MOD_RES | 264 | 264 | /note="N6-(pyridoxal phosphate)lysine" | K | ||||||||
Additional information
[?]
| Size range | 707-1007 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |