HAMAP logo

HAMAP rule MF_03050

Send feedback

General rule information [?]

Accession MF_03050
Dates 6-MAR-2009 (Created)
20-NOV-2019 (Last updated, Version 10)
Scope(s) Eukaryota
Template(s) Q96EN8 (MOCOS_HUMAN); Q9N0E7 (MOCOS_BOVIN); Q9VRA2 (MOCOS_DROME); Q9C5X8 (MOCOS_ARATH); Q9UV64 (MOCOS_EMENI); [ Recover all ]
Triggered by HAMAP; MF_03050 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MOCOS
Protein name RecName: Full=Molybdenum cofactor sulfurase;
                 Short=MoCo sulfurase;
AltName: Full=Molybdenum cofactor sulfurtransferase;
case <OC:Insecta>
Protein name + AltName: Full=Protein maroon-like;
end case
case <OC:Vertebrata>
Gene name Name=MOCOS;
end case
case <OC:Insecta>
Gene name Name=mal;
end case
case <OC:Pezizomycotina>
Gene name Name=hxB;
end case

Comments [?]

FUNCTIONSulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.
CATALYTIC ACTIVITY Reaction=AH2 + L-cysteine + Mo-molybdopterin = A + H2O + L-alanine + thio-Mo-molybdopterin; Xref=Rhea:RHEA:42636, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:35235, ChEBI:CHEBI:57972, ChEBI:CHEBI:71302, ChEBI:CHEBI:82685; EC=;
COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
SIMILARITYBelongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016829; Molecular function:lyase activity
GO:0008265; Molecular function:Mo-molybdopterin cofactor sulfurase activity
GO:0030151; Molecular function:molybdenum ion binding
GO:0030170; Molecular function:pyridoxal phosphate binding
GO:0006777; Biological process:Mo-molybdopterin cofactor biosynthetic process

Cross-references [?]

Pfam PF00266; Aminotran_5; 1;
Pfam PF03473; MOSC; 1;
Pfam PF03476; MOSC_N; 1;

Features [?]

Key From To Description Tag Condition FTGroup
ACT_SITE 424 424 C
MOD_RES 264 264 /note="N6-(pyridoxal phosphate)lysine" K

Additional information [?]

Size range 707-1007 amino acids
Related rules None
Fusion Nter: None Cter: None

View rule in raw text format (no links)