HAMAP rule MF_03050
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_03050 |
| Accession | MF_03050 |
| Dates | 19-AUG-2013 (Created)
05-NOV-2024 (Last updated, Version 13) |
| Name | MOCOS |
| Scope(s) |
Eukaryota |
| Template(s) | Q96EN8; Q9N0E7; Q9VRA2; Q9C5X8; Q9UV64; [ Recover all ] |
| Triggered by |
HAMAP; MF_03050 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MOCOS |
| Protein name | RecName: Full=Molybdenum cofactor sulfurase; Short=MCS; Short=MOS; Short=MoCo sulfurase; EC=2.8.1.9; AltName: Full=Molybdenum cofactor sulfurtransferase; |
| case <OC:Insecta> | |
| Protein name | + AltName: Full=Protein maroon-like; Short=Ma-l; |
| end case | |
| case <OC:Vertebrata> | |
| Gene name | Name=MOCOS; |
| end case | |
| case <OC:Insecta> | |
| Gene name | Name=mal; |
| end case | |
| case <OC:Pezizomycotina> | |
| Gene name | Name=hxB; |
| end case | |
Comments
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| FUNCTION | Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. |
| CATALYTIC ACTIVITY | Reaction=Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O; Xref=Rhea:RHEA:42636, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:35235, ChEBI:CHEBI:57972, ChEBI:CHEBI:71302, ChEBI:CHEBI:82685; EC=2.8.1.9; |
| COFACTOR | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; |
| SIMILARITY | Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily. |
Keywords
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Gene Ontology
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| GO:0016829; Molecular function:lyase activity |
| GO:0008265; Molecular function:molybdenum cofactor sulfurtransferase activity |
| GO:0030151; Molecular function:molybdenum ion binding |
| GO:0030170; Molecular function:pyridoxal phosphate binding |
| GO:0006777; Biological process:Mo-molybdopterin cofactor biosynthetic process |
Cross-references
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| PROSITE | PS00595; AA_TRANSFER_CLASS_5; 1; |
| PROSITE | PS51340; MOSC; 1; |
| Pfam | PF00266; Aminotran_5; 1; |
| Pfam | PF03473; MOSC; 1; |
| Pfam | PF03476; MOSC_N; 1; |
Features
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| From: MOCOS_HUMAN (Q96EN8) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 424 | 424 | C | |||||||||
| MOD_RES | 264 | 264 | /note="N6-(pyridoxal phosphate)lysine" | K | ||||||||
Additional information
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| Size range | 707-1007 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |