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Annotation rule MF_03051 |
General rule information
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Accession |
MF_03051 |
Dates |
26-FEB-2009 (Created) 20-NOV-2019 (Last updated, Version 6) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Molybdopterin synthase sulfur carrier subunit;
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AltName:
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Full=Molybdenum cofactor synthesis protein 2 small subunit;
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AltName:
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Full=Molybdenum cofactor synthesis protein 2A;
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Short=MOCS2A;
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AltName:
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Full=Sulfur carrier protein MOCS2A;
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case <OC:Pezizomycotina>
Protein name |
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Full=Common component for nitrate reductase and xanthine dehydrogenase protein G;
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end case
case <OC:Pezizomycotina>
else case <OC:Vertebrata>
else case <OC:Insecta>
end case
case <OC:Fungi>
Function |
Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by @gn(UBA4). After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin. |
else case <OC:Metazoa> or <OC:Viridiplantae>
Function |
Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by @gn(MOCS3). After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin. |
else
Function |
Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by by the MOCS3 homolog. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin. |
end case
Pathway |
Cofactor biosynthesis; molybdopterin biosynthesis. |
Subunit |
Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits. |
case <OC:Vertebrata>
Subcellular location |
Cytoplasm, cytosol. |
else
Subcellular location |
Cytoplasm. |
end case
case <OC:Fungi>
Ptm |
C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of @gn(UBA4), then thiocarboxylated (-COSH) via the rhodanese domain of @gn(UBA4). |
else case <OC:Metazoa> or <OC:Viridiplantae>
Ptm |
C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of @gn(MOCS3), then thiocarboxylated (-COSH) via the rhodanese domain of @gn(MOCS3). |
else
Ptm |
C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3 homolog. |
end case
case <OC:Mammalia>
Miscellaneous |
This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2B) from an overlapping reading frame. |
else case <OC:Vertebrata> or <OC:Insecta>
Miscellaneous |
This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2B). |
end case
Similarity |
Belongs to the MoaD family. MOCS2A subfamily. |
case <FTTag:phospho>
end case
GO:0030366; Molecular function: molybdopterin synthase activity.
GO:0006777; Biological process: Mo-molybdopterin cofactor biosynthetic process.
GO:0019008; Cellular component: molybdopterin synthase complex.
case <OC:Vertebrata>
else
end case
From: MOC2A_HUMAN (O96033) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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MOD_RES
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88
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88
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1-thioglycine; alternate
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G
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MOD_RES
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88
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88
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Glycyl adenylate; alternate
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phospho
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G
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Additional information
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Size range |
83-195 amino acids |
Related rules |
None |
Fusion |
None |