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HAMAP rule MF_03051

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General rule information [?]

Accession MF_03051
Dates 26-FEB-2009 (Created)
1-JUN-2023 (Last updated, Version 7)
Name MOCS2A
Scope
Eukaryota
Template O96033 (MOC2A_HUMAN)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MOC2A
Protein name
RecName: Full=Molybdopterin synthase sulfur carrier subunit;
AltName: Full=Molybdenum cofactor synthesis protein 2 small subunit;
AltName: Full=Molybdenum cofactor synthesis protein 2A;
Short=MOCS2A;
AltName: Full=Sulfur carrier protein MOCS2A;
case <OC:Pezizomycotina>
Protein name
Full=Common component for nitrate reductase and xanthine dehydrogenase protein G;
end case
case <OC:Pezizomycotina>
Gene name
cnxG
else case <OC:Vertebrata>
Gene name
MOCS2
else case <OC:Insecta>
Gene name
Mocs2
end case

Comments [?]

case <OC:Fungi>
Function Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by @gn(UBA4). After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
else case <OC:Metazoa> or <OC:Viridiplantae>
Function Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by @gn(MOCS3). After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
else
Function Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by by the MOCS3 homolog. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
end case
Pathway Cofactor biosynthesis; molybdopterin biosynthesis.
Subunit Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
case <OC:Vertebrata>
Subcellular location Cytoplasm, cytosol.
else
Subcellular location Cytoplasm.
end case
case <OC:Fungi>
Ptm C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of @gn(UBA4), then thiocarboxylated (-COSH) via the rhodanese domain of @gn(UBA4).
else case <OC:Metazoa> or <OC:Viridiplantae>
Ptm C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of @gn(MOCS3), then thiocarboxylated (-COSH) via the rhodanese domain of @gn(MOCS3).
else
Ptm C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3 homolog.
end case
case <OC:Mammalia>
Miscellaneous This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2B) from an overlapping reading frame.
else case <OC:Vertebrata> or <OC:Insecta>
Miscellaneous This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2B).
end case
Similarity Belongs to the MoaD family. MOCS2A subfamily.

Keywords [?]

Cytoplasm
Molybdenum cofactor biosynthesis
Nucleotide-binding
case <FTTag:phospho>
Phosphoprotein
end case

Gene Ontology [?]

GO:0030366; Molecular function: molybdopterin synthase activity.
GO:0006777; Biological process: Mo-molybdopterin cofactor biosynthetic process.
GO:0019008; Cellular component: molybdopterin synthase complex.
case <OC:Vertebrata>
GO:0005829; Cellular component: cytosol.
else
GO:0005737; Cellular component: cytoplasm.
end case

Cross-references [?]

Pfam PF02597; ThiS; 1;
NCBIfam TIGR01682; moaD; 1;
TIGR01687; moaD_arch; 1;

Features [?]

From: MOC2A_HUMAN (O96033)
Key     From     To       Description   Tag   Condition   FTGroup
MOD_RES     88     88       1-thioglycine; alternate     G  
MOD_RES     88     88       Glycyl adenylate; alternate   phospho   G  

Additional information [?]

Size range 83-195 amino acids
Related rules None
Fusion None


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