HAMAP rule MF_03051
General rule information
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Accession | MF_03051 |
Dates | 26-FEB-2009 (Created) 1-JUN-2023 (Last updated, Version 7) |
Name | MOCS2A |
Scope | Eukaryota |
Template | O96033 (MOC2A_HUMAN) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
Protein name |
|
case <OC:Pezizomycotina>
Protein name |
|
end case
case <OC:Pezizomycotina>
Gene name |
|
else case <OC:Vertebrata>
Gene name |
|
else case <OC:Insecta>
Gene name |
|
end case
Comments
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case <OC:Fungi>
Function | Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by @gn(UBA4). After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin. |
else case <OC:Metazoa> or <OC:Viridiplantae>
Function | Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by @gn(MOCS3). After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin. |
else
Function | Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by by the MOCS3 homolog. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin. |
end case
Pathway | Cofactor biosynthesis; molybdopterin biosynthesis. |
Subunit | Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits. |
case <OC:Vertebrata>
Subcellular location | Cytoplasm, cytosol. |
else
Subcellular location | Cytoplasm. |
end case
case <OC:Fungi>
Ptm | C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of @gn(UBA4), then thiocarboxylated (-COSH) via the rhodanese domain of @gn(UBA4). |
else case <OC:Metazoa> or <OC:Viridiplantae>
Ptm | C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of @gn(MOCS3), then thiocarboxylated (-COSH) via the rhodanese domain of @gn(MOCS3). |
else
Ptm | C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3 homolog. |
end case
case <OC:Mammalia>
Miscellaneous | This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2B) from an overlapping reading frame. |
else case <OC:Vertebrata> or <OC:Insecta>
Miscellaneous | This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2B). |
end case
Similarity | Belongs to the MoaD family. MOCS2A subfamily. |
Keywords
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case <FTTag:phospho>
end case
Gene Ontology
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GO:0030366; Molecular function: molybdopterin synthase activity.
GO:0006777; Biological process: Mo-molybdopterin cofactor biosynthetic process.
GO:0019008; Cellular component: molybdopterin synthase complex.
GO:0006777; Biological process: Mo-molybdopterin cofactor biosynthetic process.
GO:0019008; Cellular component: molybdopterin synthase complex.
case <OC:Vertebrata>
GO:0005829; Cellular component: cytosol.
else
GO:0005737; Cellular component: cytoplasm.
end case
Cross-references
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Features
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From: MOC2A_HUMAN (O96033) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOD_RES | 88 | 88 | 1-thioglycine; alternate | G | ||||||||
MOD_RES | 88 | 88 | Glycyl adenylate; alternate | phospho | G |
Additional information
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Size range | 83-195 amino acids |
Related rules | None |
Fusion | None |