HAMAP rule MF_03051
General rule information
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| Accession | MF_03051 |
| Dates | 26-FEB-2009 (Created)
1-JUN-2023 (Last updated, Version 7) |
| Name | MOCS2A |
| Scope(s) |
Eukaryota |
| Template(s) | O96033 (MOC2A_HUMAN); [ Recover all ] |
| Triggered by |
HAMAP; MF_03051 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MOC2A |
| Protein name | RecName: Full=Molybdopterin synthase sulfur carrier subunit; AltName: Full=Molybdenum cofactor synthesis protein 2 small subunit; AltName: Full=Molybdenum cofactor synthesis protein 2A; Short=MOCS2A; AltName: Full=Sulfur carrier protein MOCS2A; |
| case <OC:Pezizomycotina> | |
| Protein name | + AltName: Full=Common component for nitrate reductase and xanthine dehydrogenase protein G; |
| end case | |
| case <OC:Pezizomycotina> | |
| Gene name | Name=cnxG; |
| else case <OC:Vertebrata> | |
| Gene name | Name=MOCS2; |
| else case <OC:Insecta> | |
| Gene name | Name=Mocs2; |
| end case | |
Comments
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| case <OC:Fungi> | |
| FUNCTION | Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by @gn(UBA4). After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin. |
| else case <OC:Metazoa> or <OC:Viridiplantae> | |
| FUNCTION | Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by @gn(MOCS3). After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin. |
| else | |
| FUNCTION | Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by by the MOCS3 homolog. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin. |
| end case | |
| PATHWAY | Cofactor biosynthesis; molybdopterin biosynthesis. |
| SUBUNIT | Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits. |
| case <OC:Vertebrata> | |
| SUBCELLULAR LOCATION | Cytoplasm, cytosol. |
| else | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| end case | |
| case <OC:Fungi> | |
| PTM | C-terminal thiocarboxylation occurs in 2 steps, it is first acyl- adenylated (-COAMP) via the hesA/moeB/thiF part of @gn(UBA4), then thiocarboxylated (-COSH) via the rhodanese domain of @gn(UBA4). |
| else case <OC:Metazoa> or <OC:Viridiplantae> | |
| PTM | C-terminal thiocarboxylation occurs in 2 steps, it is first acyl- adenylated (-COAMP) via the hesA/moeB/thiF part of @gn(MOCS3), then thiocarboxylated (-COSH) via the rhodanese domain of @gn(MOCS3). |
| else | |
| PTM | C-terminal thiocarboxylation occurs in 2 steps, it is first acyl- adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3 homolog. |
| end case | |
| case <OC:Mammalia> | |
| MISCELLANEOUS | This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2B) from an overlapping reading frame. |
| else case <OC:Vertebrata> or <OC:Insecta> | |
| MISCELLANEOUS | This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2B). |
| end case | |
| SIMILARITY | Belongs to the MoaD family. MOCS2A subfamily. |
Keywords
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| Cytoplasm | |
| Molybdenum cofactor biosynthesis | |
| Nucleotide-binding | |
| case <FTTag:phospho> | |
| Phosphoprotein | |
| end case | |
Gene Ontology
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| GO:0030366; Molecular function:molybdopterin synthase activity | |
| GO:0006777; Biological process:Mo-molybdopterin cofactor biosynthetic process | |
| GO:0019008; Cellular component:molybdopterin synthase complex | |
| case <OCellular component:Vertebrata> | |
| GO:0005829; Cellular component:cytosol | |
| else; https://www.ebi.ac.uk/QuickGO/term/else | |
| GO:0005737; Cellular component:cytoplasm | |
| end case | |
Cross-references
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Features
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| From: MOC2A_HUMAN (O96033) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOD_RES | 88 | 88 | /note="1-thioglycine; alternate" | G | ||||||||
| MOD_RES | 88 | 88 | /note="Glycyl adenylate; alternate" | phospho | G | |||||||
Additional information
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| Size range | 83-195 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |