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HAMAP rule MF_03052

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General rule information [?]

Accession MF_03052
Dates 6-MAR-2009 (Created)
14-MAY-2022 (Last updated, Version 8)
Name MOC2B
Scope
Eukaryota
Templates O96007 (MOC2B_HUMAN); Q9Y8C1 (MOC2B_EMENI): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MOC2B
Protein name
RecName: Full=Molybdopterin synthase catalytic subunit;
EC 2.8.1.12;
AltName: Full=Molybdenum cofactor synthesis protein 2 large subunit;
AltName: Full=Molybdenum cofactor synthesis protein 2B;
Short=MOCS2B;
case <OC:Pezizomycotina>
Protein name
Full=Common component for nitrate reductase and xanthine dehydrogenase protein H;
end case
case <OC:Pezizomycotina>
Gene name
cnxH
else case <OC:Vertebrata>
Gene name
MOCS2
else case <OC:Insecta>
Gene name
Mocs2
end case

Comments [?]

Function Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
Catalytic activity RHEA:26333: 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O = 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin
EC 2.8.1.12
Pathway Cofactor biosynthesis; molybdopterin biosynthesis.
Subunit Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
case <OC:Vertebrata>
Subcellular location Cytoplasm, cytosol.
else
Subcellular location Cytoplasm.
end case
case <OC:Mammalia>
Miscellaneous This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.
else case <OC:Vertebrata> or <OC:Insecta>
Miscellaneous This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2A).
end case
Similarity Belongs to the MoaE family. MOCS2B subfamily.

Keywords [?]

Cytoplasm
Molybdenum cofactor biosynthesis
Transferase

Gene Ontology [?]

GO:0030366; Molecular function: molybdopterin synthase activity.
GO:0006777; Biological process: Mo-molybdopterin cofactor biosynthetic process.
GO:0019008; Cellular component: molybdopterin synthase complex.
case not <OC:Vertebrata>
GO:0005737; Cellular component: cytoplasm.
else
GO:0005829; Cellular component: cytosol.
end case

Cross-references [?]

Pfam PF02391; MoaE; 1;

Features [?]

From: MOC2B_HUMAN (O96007)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     143     144       /ligand="substrate     [HF]-R  
BINDING     166     168       /ligand="substrate     K-x-E  
BINDING     159     159       /ligand="substrate     K  

Additional information [?]

Size range 154-372 amino acids
Related rules None
Fusion None


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