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HAMAP rule MF_03052

General rule information [?]

Accession	MF_03052
Dates	6-MAR-2009 (Created) 28-JUN-2024 (Last updated, Version 10)
Name	MOC2B
Scope(s)	Eukaryota
Template(s)	O96007 (MOC2B_HUMAN); Q9Y8C1 (MOC2B_EMENI); [ Recover all ]
Triggered by	HAMAP; MF_03052 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	MOC2B
Protein name	RecName: Full=Molybdopterin synthase catalytic subunit; EC=2.8.1.12; AltName: Full=Molybdenum cofactor synthesis protein 2 large subunit; AltName: Full=Molybdenum cofactor synthesis protein 2B; Short=MOCS2B;
case <OC:Pezizomycotina>
Protein name	+ AltName: Full=Common component for nitrate reductase and xanthine dehydrogenase protein H;
end case
case <OC:Pezizomycotina>
Gene name	Name=cnxH;
else case <OC:Vertebrata>
Gene name	Name=MOCS2;
else case <OC:Insecta>
Gene name	Name=Mocs2;
end case

Comments [?]

FUNCTION	Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
CATALYTIC ACTIVITY	Reaction=2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O = 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin; Xref=Rhea:RHEA:26333, Rhea:RHEA-COMP:12160, Rhea:RHEA-COMP:12202, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58698, ChEBI:CHEBI:59648, ChEBI:CHEBI:90619, ChEBI:CHEBI:90778; EC=2.8.1.12;
PATHWAY	Cofactor biosynthesis; molybdopterin biosynthesis.
SUBUNIT	Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
case <OC:Vertebrata>
SUBCELLULAR LOCATION	Cytoplasm, cytosol.
else
SUBCELLULAR LOCATION	Cytoplasm.
end case
case <OC:Mammalia>
MISCELLANEOUS	This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.
else case <OC:Vertebrata> or <OC:Insecta>
MISCELLANEOUS	This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2A).
end case
SIMILARITY	Belongs to the MoaE family. MOCS2B subfamily.

Keywords [?]

Gene Ontology [?]

GO:0030366; Molecular function:molybdopterin synthase activity
GO:0006777; Biological process:Mo-molybdopterin cofactor biosynthetic process
GO:1990140; Cellular component:molybdopterin synthase complex
case not <OCellular component:Vertebrata>
GO:0005737; Cellular component:cytoplasm
else; https://www.ebi.ac.uk/QuickGO/term/else
GO:0005829; Cellular component:cytosol
end case

Cross-references [?]

Pfam	PF02391; MoaE; 1;

Features [?]

From: MOC2B_HUMAN (O96007)

Key

From

Description

Tag

Condition

FTGroup

BINDING

143

144

/ligand="substrate"

[HF]-R

BINDING

166

168

/ligand="substrate"

K-x-E

BINDING

159

/ligand="substrate"

Additional information [?]