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HAMAP rule MF_03056

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General rule information [?]

Accession MF_03056
Dates 13-MAR-2009 (Created)
20-NOV-2019 (Last updated, Version 5)
Name TRM82
Scope
Eukaryota
Templates P57081 (WDR4_HUMAN); Q03774 (TRM82_YEAST): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Fungi>
Identifier
TRM82
Protein name
RecName: Full=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit ;
AltName: Full=Transfer RNA methyltransferase 82;
else case <OC:Insecta>
Identifier
WUHO
Protein name
RecName: Full=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit ;
else case <OC:Vertebrata> or <OC:Dictyostelium>
Identifier
WDR4
Protein name
RecName: Full=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit ;
AltName: Full=WD repeat-containing protein 4;
else
Identifier
WDR4
Protein name
RecName: Full=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit;
AltName: Full=WD repeat-containing protein 4 homolog;
end case
case <OC:Vertebrata> or <OC:Dictyostelium>
Gene name
WDR4
else case <OC:Fungi>
Gene name
TRM82
else case <OC:Insecta>
Gene name
wuho
end case

Comments [?]

case <OC:Drosophilidae>
Function Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Required during gametogenesis.
else case <OC:Saccharomyces>
Function Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
else
Function Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
end case
Pathway tRNA modification; N(7)-methylguanine-tRNA biosynthesis.
case <OC:Vertebrata> or <OC:Dictyostelium>
Subunit Forms a heterodimer with the catalytic subunit @gn(METTL1).
else case <OC:Fungi>
Subunit Forms a heterodimer with the catalytic subunit @gn(TRM8).
else
Subunit Forms a heterodimer with the catalytic subunit.
end case
case <OC:Drosophilidae>
Subcellular location Nucleus. Note=Localized to the nuclei of nurse cells, follicle cells and oocytes at early stages, from germarium to stage 4 egg chambers. Also present in the nuclei of spermatocytes and in the apical cells of the testes.
else
Subcellular location Nucleus.
end case
Similarity Belongs to the WD repeat TRM82 family.

Keywords [?]

Nucleus
Repeat
tRNA processing
WD repeat
case <OC:Drosophilidae>
Developmental protein
Differentiation
Oogenesis
Spermatogenesis
end case

Gene Ontology [?]

GO:0005634; Cellular component: nucleus.
GO:0030488; Biological process: tRNA methylation.
case <OC:Drosophilidae>
GO:0007283; Biological process: spermatogenesis.
GO:0048477; Biological process: oogenesis.
end case

Cross-references [?]

PROSITE PS00678; WD_REPEATS_1; 1;
PS50082; WD_REPEATS_2; 1;
PS50294; WD_REPEATS_REGION; 1;
Pfam PF00400; WD40; 1;

Computed features [?]

case not <OC:Saccharomyces>
REP Repeat_WD40; WD40; 2-7; trigger=yes;
end case

Features [?]

case <OC:Saccharomyces>
From: TRM82_YEAST (Q03774)
Key     From     To       Description   Tag   Condition   FTGroup
REPEAT     1     47       WD 1        
REPEAT     48     99       WD 2        
REPEAT     100     147       WD 3        
REPEAT     148     192       WD 4        
REPEAT     193     237       WD 5        
REPEAT     238     279       WD 6        
REPEAT     308     354       WD 7        
end case

Additional information [?]

Size range 340-569 amino acids
Related rules None
Fusion None


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