HAMAP rule MF_03056
General rule information
[?]
Accession |
MF_03056 |
Dates |
13-MAR-2009 (Created) 20-NOV-2019 (Last updated, Version 5) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Fungi>
Protein name |
RecName:
|
Full=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit ;
|
AltName:
|
Full=Transfer RNA methyltransferase 82;
|
|
else case <OC:Insecta>
Protein name |
RecName:
|
Full=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit ;
|
|
else case <OC:Vertebrata> or <OC:Dictyostelium>
Protein name |
RecName:
|
Full=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit ;
|
AltName:
|
Full=WD repeat-containing protein 4;
|
|
else
Protein name |
RecName:
|
Full=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit;
|
AltName:
|
Full=WD repeat-containing protein 4 homolog;
|
|
end case
case <OC:Vertebrata> or <OC:Dictyostelium>
else case <OC:Fungi>
else case <OC:Insecta>
end case
case <OC:Drosophilidae>
Function |
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Required during gametogenesis. |
else case <OC:Saccharomyces>
Function |
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. |
else
Function |
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. |
end case
Pathway |
tRNA modification; N(7)-methylguanine-tRNA biosynthesis. |
case <OC:Vertebrata> or <OC:Dictyostelium>
Subunit |
Forms a heterodimer with the catalytic subunit @gn(METTL1). |
else case <OC:Fungi>
Subunit |
Forms a heterodimer with the catalytic subunit @gn(TRM8). |
else
Subunit |
Forms a heterodimer with the catalytic subunit. |
end case
case <OC:Drosophilidae>
Subcellular location |
Nucleus. Note=Localized to the nuclei of nurse cells, follicle cells and oocytes at early stages, from germarium to stage 4 egg chambers. Also present in the nuclei of spermatocytes and in the apical cells of the testes. |
else
Subcellular location |
Nucleus. |
end case
Similarity |
Belongs to the WD repeat TRM82 family. |
case <OC:Drosophilidae>
end case
case <OC:Drosophilidae>
end case
case not <OC:Saccharomyces>
REP |
Repeat_WD40; WD40; 2-7; trigger=yes; |
end case
case <OC:Saccharomyces>
From: TRM82_YEAST (Q03774) |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
REPEAT
|
|
1
|
|
47
|
|
WD 1
|
|
|
|
|
|
|
REPEAT
|
|
48
|
|
99
|
|
WD 2
|
|
|
|
|
|
|
REPEAT
|
|
100
|
|
147
|
|
WD 3
|
|
|
|
|
|
|
REPEAT
|
|
148
|
|
192
|
|
WD 4
|
|
|
|
|
|
|
REPEAT
|
|
193
|
|
237
|
|
WD 5
|
|
|
|
|
|
|
REPEAT
|
|
238
|
|
279
|
|
WD 6
|
|
|
|
|
|
|
REPEAT
|
|
308
|
|
354
|
|
WD 7
|
|
|
|
|
|
|
end case
Additional information
[?]
Size range |
340-569 amino acids |
Related rules |
None |
Fusion |
None |