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HAMAP rule MF_03056

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General rule information [?]

Accession MF_03056
Dates 13-MAR-2009 (Created)
23-MAY-2024 (Last updated, Version 6)
Name TRM82
Scope(s) Eukaryota
Template(s) P57081 (WDR4_HUMAN); Q03774 (TRM82_YEAST); [ Recover all ]
Triggered by HAMAP; MF_03056 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Fungi>
Identifier TRM82
Protein name RecName: Full=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit ;
AltName: Full=Transfer RNA methyltransferase 82;
else case <OC:Insecta>
Identifier WUHO
Protein name RecName: Full=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit ;
else case <OC:Vertebrata> or <OC:Dictyostelium>
Identifier WDR4
Protein name RecName: Full=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit ;
AltName: Full=WD repeat-containing protein 4;
else
Identifier WDR4
Protein name RecName: Full=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit;
AltName: Full=WD repeat-containing protein 4 homolog;
end case
case <OC:Vertebrata> or <OC:Dictyostelium>
Gene name Name=WDR4;
else case <OC:Fungi>
Gene name Name=TRM82;
else case <OC:Insecta>
Gene name Name=wuho;
end case

Comments [?]

case <OC:Drosophilidae>
FUNCTIONRequired for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Required during gametogenesis.
else case <OC:Saccharomyces>
FUNCTIONRequired for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
else
FUNCTIONRequired for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
end case
PATHWAYtRNA modification; N(7)-methylguanine-tRNA biosynthesis.
case <OC:Vertebrata> or <OC:Dictyostelium>
SUBUNITForms a heterodimer with the catalytic subunit @gn(METTL1).
else case <OC:Fungi>
SUBUNITForms a heterodimer with the catalytic subunit @gn(TRM8).
else
SUBUNITForms a heterodimer with the catalytic subunit.
end case
case <OC:Drosophilidae>
SUBCELLULAR LOCATIONNucleus. Note=Localized to the nuclei of nurse cells, follicle cells and oocytes at early stages, from germarium to stage 4 egg chambers. Also present in the nuclei of spermatocytes and in the apical cells of the testes.
else
SUBCELLULAR LOCATIONNucleus.
end case
SIMILARITYBelongs to the WD repeat TRM82 family.

Keywords [?]


Gene Ontology [?]

GO:0005634; Cellular component:nucleus
GO:0106004; Biological process:tRNA (guanine-N7)-methylation
case <OCellular component:Drosophilidae>
GO:0007283; Biological process:spermatogenesis
GO:0048477; Biological process:oogenesis
end case

Cross-references [?]

REP Repeat_WD40; WD40; 2-7;
PROSITE PS00678; WD_REPEATS_1; 1;
PROSITE PS50082; WD_REPEATS_2; 1;
PROSITE PS50294; WD_REPEATS_REGION; 1;
Pfam PF00400; WD40; 1;

Features [?]

From: TRM82_YEAST (Q03774)
Key From To Description Tag Condition FTGroup
case <OC:Saccharomyces>
REPEAT 1 47 /note="WD 1"
REPEAT 48 99 /note="WD 2"
REPEAT 100 147 /note="WD 3"
REPEAT 148 192 /note="WD 4"
REPEAT 193 237 /note="WD 5"
REPEAT 238 279 /note="WD 6"
REPEAT 308 354 /note="WD 7"
end case

Additional information [?]

Size range 340-569 amino acids
Related rules None
Fusion Nter: None Cter: None



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