HAMAP rule MF_03058

General rule information [?]

Accession	MF_03058
Dates	3-JUN-2009 (Created) 20-NOV-2019 (Last updated, Version 6)

Name

VMA21

Scope

Eukaryota

Templates

Q3ZAQ7 (VMA21_HUMAN); P41806 (VMA21_YEAST): [Recover all]

Triggered by

HAMAP; MF_03058 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

VMA21

case <OC:Vertebrata> or <OC:Fungi>

Protein name

RecName:

Full=Vacuolar ATPase assembly integral membrane protein ;

Gene name

VMA21

else

Protein name

RecName:

Full=Vacuolar ATPase assembly integral membrane protein VMA21 homolog;

end case

Comments [?]

case <OC:Saccharomyces>

Function

Functions with VOA1 in assembly of the integral membrane sector (also called V0 sector) of the V-ATPase in the endoplasmic reticulum. Escorts the assembled V0 sector in COPII vesicles. Also required for normal packaging of the SNARE BOS1 and possibly the ER to Golgi transport receptor ERV29.

else

Function

Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.

end case

case <OC:Mammalia>

Subunit

Associates with the V0 complex of the vacuolar ATPase (V-ATPase).

end case

Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.
Similarity	Belongs to the VMA21 family.

Keywords [?]

Cytoplasmic vesicle
Endoplasmic reticulum
Membrane
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0070072; Biological process: vacuolar proton-transporting V-type ATPase complex assembly.
GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0012507; Cellular component: ER to Golgi transport vesicle membrane.

Computed features [?]

General	Transmembrane; -; 2;
ADD_TOPO_DOMAIN	Cytoplasmic; -; 2; trigger=yes;
	Lumenal; -; 1; trigger=yes;

Features [?]

case <OC:Fungi>

From: VMA21_YEAST (P41806)

Key From To Description Tag Condition FTGroup

MOTIF 74 77 Prevents secretion from ER K-K-x-x

end case

Additional information [?]

Size range	72-127 amino acids
Related rules	None
Fusion	None

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