HAMAP logo

HAMAP rule MF_03058

Send feedback

General rule information [?]

Accession MF_03058
Dates 3-JUN-2009 (Created)
20-NOV-2019 (Last updated, Version 6)
Name VMA21
Templates Q3ZAQ7 (VMA21_HUMAN); P41806 (VMA21_YEAST): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Vertebrata> or <OC:Fungi>
Protein name
RecName: Full=Vacuolar ATPase assembly integral membrane protein ;
Gene name
Protein name
RecName: Full=Vacuolar ATPase assembly integral membrane protein VMA21 homolog;
end case

Comments [?]

case <OC:Saccharomyces>
Function Functions with VOA1 in assembly of the integral membrane sector (also called V0 sector) of the V-ATPase in the endoplasmic reticulum. Escorts the assembled V0 sector in COPII vesicles. Also required for normal packaging of the SNARE BOS1 and possibly the ER to Golgi transport receptor ERV29.
Function Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.
end case
case <OC:Mammalia>
Subunit Associates with the V0 complex of the vacuolar ATPase (V-ATPase).
end case
Subcellular location Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.
Similarity Belongs to the VMA21 family.

Keywords [?]

Gene Ontology [?]

GO:0070072; Biological process: vacuolar proton-transporting V-type ATPase complex assembly.
GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0012507; Cellular component: ER to Golgi transport vesicle membrane.

Computed features [?]

General Transmembrane; -; 2;
ADD_TOPO_DOMAIN Cytoplasmic; -; 2; trigger=yes;
Lumenal; -; 1; trigger=yes;

Features [?]

case <OC:Fungi>
From: VMA21_YEAST (P41806)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     74     77       Prevents secretion from ER     K-K-x-x  
end case

Additional information [?]

Size range 72-127 amino acids
Related rules None
Fusion None