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HAMAP rule MF_03058

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General rule information [?]

Accession MF_03058
Dates 3-JUN-2009 (Created)
20-NOV-2019 (Last updated, Version 6)
Name VMA21
Scope(s) Eukaryota
Template(s) Q3ZAQ7 (VMA21_HUMAN); P41806 (VMA21_YEAST); [ Recover all ]
Triggered by HAMAP; MF_03058 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier VMA21
case <OC:Vertebrata> or <OC:Fungi>
Protein name RecName: Full=Vacuolar ATPase assembly integral membrane protein ;
Gene name Name=VMA21;
Protein name RecName: Full=Vacuolar ATPase assembly integral membrane protein VMA21 homolog;
end case

Comments [?]

case <OC:Saccharomyces>
FUNCTIONFunctions with VOA1 in assembly of the integral membrane sector (also called V0 sector) of the V-ATPase in the endoplasmic reticulum. Escorts the assembled V0 sector in COPII vesicles. Also required for normal packaging of the SNARE BOS1 and possibly the ER to Golgi transport receptor ERV29.
FUNCTIONRequired for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.
end case
case <OC:Mammalia>
SUBUNITAssociates with the V0 complex of the vacuolar ATPase (V- ATPase).
end case
SUBCELLULAR LOCATIONEndoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII- coated vesicle membrane; Multi-pass membrane protein.
SIMILARITYBelongs to the VMA21 family.

Keywords [?]

Gene Ontology [?]

GO:0070072; Biological process:vacuolar proton-transporting V-type ATPase complex assembly
GO:0005789; Cellular component:endoplasmic reticulum membrane
GO:0012507; Cellular component:ER to Golgi transport vesicle membrane

Cross-references [?]

General Transmembrane; -; 2;
ADD_TOPO_DOMAIN Cytoplasmic; -; 2;
ADD_TOPO_DOMAIN Lumenal; -; 1;

Features [?]

From: VMA21_YEAST (P41806)
Key From To Description Tag Condition FTGroup
case <OC:Fungi>
MOTIF 74 77 /note="Prevents secretion from ER" K-K-x-x
end case

Additional information [?]

Size range 72-127 amino acids
Related rules None
Fusion Nter: None Cter: None

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