HAMAP rule MF_03059
General rule information
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Accession | MF_03059 |
Dates | 4-SEP-2009 (Created) 19-NOV-2022 (Last updated, Version 10) |
Name | mEF_G_2 |
Scope | Eukaryota |
Templates | Q969S9 (RRF2M_HUMAN); P39677 (RRF2M_YEAST): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
Protein name |
|
case <OC:Vertebrata>
Gene name |
|
else case <OC:Fungi>
Gene name |
|
end case
Comments
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case <OC:Vertebrata>
Function | Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with @gn(MRRF). GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation. |
else
Function | Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation. |
end case
Subcellular location | Mitochondrion. |
case not <AnyFeature:TransitM>
Miscellaneous | This protein may be expected to contain an N-terminal transit peptide but none has been predicted. |
end case
Similarity | Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. |
Keywords
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Gene Ontology
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GO:0003924; Molecular function: GTPase activity.
GO:0005525; Molecular function: GTP binding.
GO:0032543; Biological process: mitochondrial translation.
GO:0032790; Biological process: ribosome disassembly.
GO:0005739; Cellular component: mitochondrion.
GO:0005525; Molecular function: GTP binding.
GO:0032543; Biological process: mitochondrial translation.
GO:0032790; Biological process: ribosome disassembly.
GO:0005739; Cellular component: mitochondrion.
Cross-references
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PROSITE | PS00301; G_TR_1; 1; |
PS51722; G_TR_2; 1; | |
Pfam | PF00679; EFG_C; 1; |
PF03764; EFG_IV; 1; | |
PF00009; GTP_EFTU; 1; | |
PF03144; GTP_EFTU_D2; 1; | |
PRINTS | PR00315; ELONGATNFCT; 1; |
TIGRFAMs | TIGR00231; small_GTP; 1; |
Computed features
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General | TransitM; -; 0-1; trigger=yes; |
Features
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From: RRF2M_HUMAN (Q969S9) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 77 | 84 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | A-H-I-D-[AG]-G-K-T | ||||||||
BINDING | 141 | 145 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | D-T-P-G-H | ||||||||
BINDING | 195 | 198 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | N-K-[ML]-D |
Additional information
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Size range | 692-931 amino acids |
Related rules | None |
Fusion | None |