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HAMAP rule MF_03059

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General rule information [?]

Accession MF_03059
Dates 4-SEP-2009 (Created)
19-NOV-2022 (Last updated, Version 10)
Name mEF_G_2
Scope
Eukaryota
Templates Q969S9 (RRF2M_HUMAN); P39677 (RRF2M_YEAST): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RRF2M
Protein name
RecName: Full=Ribosome-releasing factor 2, mitochondrial;
Short=RRF2mt;
AltName: Full=Elongation factor G 2, mitochondrial;
Short=mEF-G 2;
Short=EF-G2mt;
case <OC:Vertebrata>
Gene name
GFM2, EFG2
else case <OC:Fungi>
Gene name
MEF2
end case

Comments [?]

case <OC:Vertebrata>
Function Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with @gn(MRRF). GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
else
Function Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
end case
Subcellular location Mitochondrion.
case not <AnyFeature:TransitM>
Miscellaneous This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case
Similarity Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

Keywords [?]

GTP-binding
Mitochondrion
Nucleotide-binding
Protein biosynthesis

Gene Ontology [?]

GO:0003924; Molecular function: GTPase activity.
GO:0005525; Molecular function: GTP binding.
GO:0032543; Biological process: mitochondrial translation.
GO:0032790; Biological process: ribosome disassembly.
GO:0005739; Cellular component: mitochondrion.

Cross-references [?]

PROSITE PS00301; G_TR_1; 1;
PS51722; G_TR_2; 1;
Pfam PF00679; EFG_C; 1;
PF03764; EFG_IV; 1;
PF00009; GTP_EFTU; 1;
PF03144; GTP_EFTU_D2; 1;
PRINTS PR00315; ELONGATNFCT; 1;
TIGRFAMs TIGR00231; small_GTP; 1;

Computed features [?]

General TransitM; -; 0-1; trigger=yes;

Features [?]

From: RRF2M_HUMAN (Q969S9)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     77     84       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     A-H-I-D-[AG]-G-K-T  
BINDING     141     145       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     D-T-P-G-H  
BINDING     195     198       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     N-K-[ML]-D  

Additional information [?]

Size range 692-931 amino acids
Related rules None
Fusion None


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