HAMAP rule MF_03059

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_03059
Accession	MF_03059
Dates	4-SEP-2009 (Created) 1-JUN-2023 (Last updated, Version 11)
Name	mEF_G_2
Scope(s)	Eukaryota
Template(s)	Q969S9 (RRF2M_HUMAN); P39677 (RRF2M_YEAST); [ Recover all ]
Triggered by	HAMAP; MF_03059 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	RRF2M
Protein name	RecName: Full=Ribosome-releasing factor 2, mitochondrial; Short=RRF2mt; AltName: Full=Elongation factor G 2, mitochondrial; Short=mEF-G 2; Short=EF-G2mt;
case <OC:Vertebrata>
Gene name	Name=GFM2; Synonyms=EFG2;
else case <OC:Fungi>
Gene name	Name=MEF2;
end case

Comments [?]

case <OC:Vertebrata>
FUNCTION	Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with @gn(MRRF). GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
else
FUNCTION	Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
end case
SUBCELLULAR LOCATION	Mitochondrion.
case not <AnyFeature:TransitM>
MISCELLANEOUS	This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case
SIMILARITY	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0003924; Molecular function:GTPase activity

GO:0005525; Molecular function:GTP binding

GO:0032543; Biological process:mitochondrial translation

GO:0032790; Biological process:ribosome disassembly

GO:0005739; Cellular component:mitochondrion

Cross-references [?]

Features [?]

From: RRF2M_HUMAN (Q969S9)

Key

From

Description

Tag

Condition

FTGroup

BINDING

/ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"

A-H-I-D-[AG]-G-K-T

BINDING

141

145

/ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"

D-T-P-G-H

BINDING

195

198

/ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"

N-K-[ML]-D

Additional information [?]