![]() |
|
Annotation rule MF_03071 |
Accession | MF_03071 |
Dates | 5-MAR-2009 (Created) 27-JUN-2022 (Last updated, Version 10) |
Name | CHD8 |
Scope | Eukaryota; Vertebrata |
Templates | Q9HCK8 (CHD8_HUMAN); Q09XV5 (CHD8_MOUSE); Q9JIX5 (CHD8_RAT): [Recover all] |
Triggered by |
Identifier |
|
Protein name |
|
Gene name |
|
Function | DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. |
Catalytic activity | RHEA:13065: ATP + H2O = ADP + H(+) + phosphate
EC 3.6.4.12 |
Subunit | Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Interacts with FAM124B. |
Subcellular location | Nucleus. Note=Localizes to the promoter regions of several CTNNB1-responsive genes. Also present at known CTCF target sites. |
Ptm | Sumoylated. |
Function | DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/@gn(TP53)-mediated apoptosis by recruiting histone H1 and preventing p53/@gn(TP53) transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (@gn(CTNNB1)) activity. Negatively regulates @gn(CTNNB1)-targeted gene expression by being recruited specifically to the promoter regions of several @gn(CTNNB1) responsive genes. May also act as a transcription activator by participating in efficient U6 RNA polymerase III transcription. |
Catalytic activity | RHEA:13065: ATP + H2O = ADP + H(+) + phosphate
EC 3.6.4.12 |
Subunit | Component of some MLL1/MLL complex. |
Subcellular location | Nucleus. |
Similarity | Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily. |
PROSITE | PS00598; CHROMO_1; 2; |
PS50013; CHROMO_2; 2; | |
PS00690; DEAH_ATP_HELICASE; 1; | |
PS51192; HELICASE_ATP_BIND_1; 1; trigger=PRU00541; | |
PS51194; HELICASE_CTER; 1; trigger=PRU00542; | |
PS50312; ASP_RICH; 0-unlimited; | |
PS50322; GLN_RICH; 0-unlimited; | |
PS50324; SER_RICH; 0-unlimited; | |
PS50316; HIS_RICH; 0-unlimited; | |
Pfam | PF07533; BRK; 1; |
PF00385; Chromo; 2; | |
PF00271; Helicase_C; 1; | |
PF00176; SNF2_N; 1; |
From: CHD8_HUMAN (Q9HCK8) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 1789 | 2302 | Interaction with FAM124B |
From: CHD8_RAT (Q9JIX5) | ||||||||||||
CROSSLNK | 609 | 609 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) | sumo | K |
Size range | 2184-2594 amino acids |
Related rules | None |
Fusion | None |