HAMAP rule MF_03103

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_03103
Accession	MF_03103
Dates	14-AUG-2009 (Created) 29-SEP-2022 (Last updated, Version 11)
Name	Mmm1
Scope(s)	Eukaryota Fungi
Template(s)	P41800 (MMM1_YEAST); [ Recover all ]
Triggered by	HAMAP; MF_03103 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	MMM1
case <OC:Saccharomyces>
Protein name	RecName: Full=Maintenance of mitochondrial morphology protein 1; AltName: Full=Mitochondrial outer membrane protein ; AltName: Full=Yeast mitochondrial escape protein 6;
else
Protein name	RecName: Full=Maintenance of mitochondrial morphology protein 1;
end case
Gene name	Name=MMM1;

Comments [?]

FUNCTION	Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The @gn(MDM12)- subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The @gn(MDM10)-@gn(MDM12)- subcomplex further acts in the TOM40-specific pathway after the action of the @gn(MDM12)- complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
SUBUNIT	Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of , @gn(MDM10), @gn(MDM12) and @gn(MDM34). A homodimer associates with one molecule of @gn(MDM12) on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of and @gn(MDM12) generate a continuous hydrophobic tunnel for phospholipid trafficking.
SUBCELLULAR LOCATION	Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
SIMILARITY	Belongs to the MMM1 family.

Keywords [?]

Gene Ontology [?]

GO:0005789; Cellular component:endoplasmic reticulum membrane

GO:0032865; Cellular component:ERMES complex

GO:0000002; Biological process:mitochondrial genome maintenance

GO:0045040; Biological process:protein insertion into mitochondrial outer membrane

Cross-references [?]

Features [?]

From: MMM1_YEAST (P41800)

Key

From

Description

Tag

Condition

FTGroup

TOPO_DOM

Nter

100

/note="Lumenal"

TRANSMEM

101

121

/note="Helical"

TOPO_DOM

122

Cter

/note="Cytoplasmic"

Additional information [?]