HAMAP logo

HAMAP rule MF_03103

Send feedback

General rule information [?]

Accession MF_03103
Dates 14-AUG-2009 (Created)
29-SEP-2022 (Last updated, Version 11)
Name Mmm1
Eukaryota; Fungi
Template P41800 (MMM1_YEAST)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Saccharomyces>
Protein name
RecName: Full=Maintenance of mitochondrial morphology protein 1;
AltName: Full=Mitochondrial outer membrane protein ;
AltName: Full=Yeast mitochondrial escape protein 6;
Protein name
RecName: Full=Maintenance of mitochondrial morphology protein 1;
end case
Gene name

Comments [?]

Function Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The @gn(MDM12)- subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The @gn(MDM10)-@gn(MDM12)- subcomplex further acts in the TOM40-specific pathway after the action of the @gn(MDM12)- complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
Subunit Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of , @gn(MDM10), @gn(MDM12) and @gn(MDM34). A homodimer associates with one molecule of @gn(MDM12) on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of and @gn(MDM12) generate a continuous hydrophobic tunnel for phospholipid trafficking.
Subcellular location Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Similarity Belongs to the MMM1 family.

Keywords [?]

Gene Ontology [?]

GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0032865; Cellular component: ERMES complex.
GO:0000002; Biological process: mitochondrial genome maintenance.
GO:0045040; Biological process: protein insertion into mitochondrial outer membrane.

Cross-references [?]

PROSITE PS51847; SMP; 1; trigger=PRU01194;
Pfam PF10296; DUF2404; 1;

Computed features [?]

General Transmembrane; -; 0-1;

Features [?]

From: MMM1_YEAST (P41800)
Key     From     To       Description   Tag   Condition   FTGroup
TOPO_DOM     Nter     100       Lumenal        
TRANSMEM     101     121       Helical        
TOPO_DOM     122     Cter       Cytoplasmic        

Additional information [?]

Size range 291-591 amino acids
Related rules None
Fusion None