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HAMAP rule MF_03103

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General rule information [?]

Accession MF_03103
Dates 14-AUG-2009 (Created)
29-SEP-2022 (Last updated, Version 11)
Name Mmm1
Scope(s) Eukaryota
Template(s) P41800 (MMM1_YEAST); [ Recover all ]
Triggered by HAMAP; MF_03103 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MMM1
case <OC:Saccharomyces>
Protein name RecName: Full=Maintenance of mitochondrial morphology protein 1;
AltName: Full=Mitochondrial outer membrane protein ;
AltName: Full=Yeast mitochondrial escape protein 6;
Protein name RecName: Full=Maintenance of mitochondrial morphology protein 1;
end case
Gene name Name=MMM1;

Comments [?]

FUNCTIONComponent of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The @gn(MDM12)- subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The @gn(MDM10)-@gn(MDM12)- subcomplex further acts in the TOM40-specific pathway after the action of the @gn(MDM12)- complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
SUBUNITHomodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of , @gn(MDM10), @gn(MDM12) and @gn(MDM34). A homodimer associates with one molecule of @gn(MDM12) on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of and @gn(MDM12) generate a continuous hydrophobic tunnel for phospholipid trafficking.
SUBCELLULAR LOCATIONEndoplasmic reticulum membrane; Single-pass type I membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
SIMILARITYBelongs to the MMM1 family.

Keywords [?]

Gene Ontology [?]

GO:0005789; Cellular component:endoplasmic reticulum membrane
GO:0032865; Cellular component:ERMES complex
GO:0000002; Biological process:mitochondrial genome maintenance
GO:0045040; Biological process:protein insertion into mitochondrial outer membrane

Cross-references [?]

PROSITE PS51847; SMP; 1;
Pfam PF10296; DUF2404; 1;
General Transmembrane; -; 0-1;

Features [?]

From: MMM1_YEAST (P41800)
Key From To Description Tag Condition FTGroup
TOPO_DOM Nter 100 /note="Lumenal"
TRANSMEM 101 121 /note="Helical"
TOPO_DOM 122 Cter /note="Cytoplasmic"

Additional information [?]

Size range 291-591 amino acids
Related rules None
Fusion Nter: None Cter: None

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